DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and gria4b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	878	Identity:	348/878 - (39%)
Similarity:	520/878 - (59%)	Gaps:	76/878 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LQLILNC---RKAQSLPDIIKIGGLFHPADDHQELAFRQAV--DRINADRSILPRSKLVAQIERI 73
            |.|:.:|   ....:.|..::|||||....|.:..|||.|:  ...:.:.|..| ..||..::.|
Zfish     8 LLLLFSCVWGLTMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAP-FNLVPHVDNI 71

  Fly    74 SPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRR 130
            ...:||......|...:.||.||||.....:...:.|.|..:.|..:        |:::..:||
Zfish    72 ETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCGALHISLITPSFPTEGESQFVLQLR- 135

  Fly   131 ESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT---VRQL 192
                       .::..|.:.::.|:.|..|..:|:.:.|...||.:::..|...:.::   |...
Zfish   136 -----------PSIRGALLSLLDHYDWNRFVFLYDTDRGYSILQAIMEKAGQNGWQVSAICVENF 189

  Fly   193 SDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEF 256
            :|: .||.||:.:....|...|:|...||::.:|:|...:|. :..|| |::.:|....:||:.|
Zfish   190 NDA-SYRQLLEDLDRRQEKTFVIDLEAERLNNMLEQIVSVGKHVKGYH-YIMANLGFKDINLERF 252

  Fly   257 RYGGTNITGFRLI--NEKIVSDVVRQWS-IDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDL 318
            .:||.|:|||:|:  :..:|..::::|: :|::....|.  ...:..:||.||.|.:.|:|..:|
Zfish   253 MHGGANVTGFQLVDFSNPMVIKLMQRWNKLDQREYPGSD--APPKYTSALTYDGVMVMAEAFRNL 315

  Fly   319 DTSQQIDIHPISCDGQ------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVEL 377
             ..|::||......|.      :.|..|..:...:|.|.::|||..::|||.|.|.::.:|:.||
Zfish   316 -RRQKVDISRRGIAGDCLANPAAPWNQGIDMERTLKQVHLQGLTGNVQFDHYGRRVNYTMDVFEL 379

  Fly   378 TPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGND 442
            ...|.|:||.||..  |.:..|:..:....| .:.::|:|::||||:..||.|.|::.....||:
Zfish   380 KSNGPRRIGYWNDA--DKLVLTQDHALLPNE-TSGMENRTVIVTTIMEGPYVMLKKNWEMYEGNE 441

  Fly   443 QFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFE 507
            |:|||.|||..||:|.:||.|||.:||||.||:.:..|..||||:.||:..:|::|:|.||||..
Zfish   442 QYEGYCVDLASEIAKHIGFKYKISIVPDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLV 506

  Fly   508 REQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPY 572
            ||:.:||:.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||
Zfish   507 REEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPY 571

  Fly   573 EWPAYTDAHGEKVE------------SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWF 625
            ||      |.|:.|            ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||
Zfish   572 EW------HTEEPEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 630

  Fly   626 FTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWS 690
            ||||:|||||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::|||
Zfish   631 FTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWS 695

  Fly   691 FMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATP 754
            :|:||.|:|||.:..|||.||.|.||.||||:|||..||..:|. |:..:|||.||:|.||:|||
Zfish   696 YMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATP 760

  Fly   755 PNSPYRTAINSVILKLQEEGKLHILKTKWWKEK----RGGGKCRVETSKSSSAANELGLANVGGV 815
            ..|..|:|:|..:|||.|:|.|..||.|||.:|    .|||.   |..|||.|   |.|:||.||
Zfish   761 KGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGG---EKDKSSQA---LSLSNVAGV 819

  Fly   816 FVVLMGGMGVACVIAVCEFVWKSRKVAVEERLS 848
            |.:|:||:|:|.::|:.||.:|||..|...:|:
Zfish   820 FYILVGGLGLAMLVALIEFCYKSRNEAKRMKLT 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	105/388 (27%)
		ANF_receptor	42..378	CDD:279440	91/358 (25%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	207/382 (54%)
		Lig_chan	547..823	CDD:278489	158/292 (54%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	105/389 (27%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	208/384 (54%)
		Lig_chan	546..827	CDD:306551	158/292 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820