Protein Alignment KaiR1D and GABA-B-R3

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Alignment Length: 945
• Identity: 176/945 - (18%)
• Similarity: 295/945 - (31%)
• Gaps: 306/945 - (32%)

  Fly    34 GLFHPA-------DDHQEL-AFRQAVDRINADRSILP--RSKLVAQIERISP------FDSFHA- 81
            |||..:       |...|| |...||:.||..| :||  ..:||....:..|      |  |||
  Fly   157 GLFELSTSRGPRPDGLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRF--FHAI 218

  Fly    82 ----GKRVCGLL------------------NIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRW 124
                ..|:..||                  || |...||..|       .::.|..|.|:.
  Fly   219 YTQPSTRMVMLLGSACSEVTESLAKVVPYWNI-VQVSFGSTS-------PALSDRREFPYF---- 271

  Fly   125 DYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENND----GIVRLQELLKAHGMT-- 183
             ||        .:.| .::.:.|.:..:|.:||.|.|...:|.:    .:..|...|:|..::
  Fly   272 -YR--------TVAP-DSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCA 326

  Fly   184 ---PFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLV-- 243
               .|..|        |::..|..::.:....|:...|.|...::|.:|.::.|....:::::
  Fly   327 ATITFAAT--------DFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHE 383

  Fly   244 -----------TSLDLHTVNL---------DEFRYGGTNITGFRLINEKIVSDVVRQWSID---- 284
                       |:...|.:.|         ......|.|:: :..:|..:.:..:|:.|..
  Fly   384 SMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVS-YSGLNNHMFNSQLRKQSAQFHGQ 447

  Fly   285 ---EKGLLRSANLTTVRSET-------------------------ALMYDAVHLFAKALHDLDTS 321
               ..|.....::...:|::                         ...||||...|.||...:..
  Fly   448 DGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEH 512

  Fly   322 QQIDIHPISCDG------QSTWQHGFSLINYMKIVEMKGLTNVIKFD------------------ 362
            .:.:......||      ...|:    .:..|..:...|::..:.|.
  Fly   513 WRRNEEQSKLDGFDYTRSDMAWE----FLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLL 573

  Fly   363 -------------------------HQG----FRTDFMLDIVELTPAGIRKIGTWNSTLPDGINF 398
                                     |.|    .:..|.|.:..:.|.....|.|.:|.   ||..
  Fly   574 EPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSV---GIAL 635

  Fly   399 TRTF------SQKQQEIEAN---LKNKTLV------VTTILSNPYCMRKESAIPLSGNDQF---- 444
            ...|      .:|.:.|:.:   |.|.|.|      .|.||..    ...|.:| |..|.|
  Fly   636 AIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLG----LDHSTLP-SAEDSFATVC 695

  Fly   445 --------EGYAVDL---------IHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLE 492
                    .|:::..         :|.|....|..:|.:::.|   ..|..|.|   |::
  Fly   696 TARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQD---IQLILLVG---GLL----- 749

  Fly   493 QRADLAIADLTITFEREQAVDFTTPF------MNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIY 551
             ..|..:..|.:.         |.|.      :.|.:|...|..:.||.  ...........|:.
  Fly   750 -LVDALLVTLWVV---------TDPMERHLHNLTLEISATDRSVVYQPQ--VEVCRSQHTQTWLS 802

  Fly   552 MATAYLGVSVLLFILAKFTPYEW-----PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLP 611
            :..||.|   ||.::..:..:|.     ||..|       ||:..::.....|.|.:   ...|.
  Fly   803 VLYAYKG---LLLVVGVYMAWETRHVKIPALND-------SQYIGVSVYSVVITSAI---VVVLA 854

  Fly   612 KALSTRMVAGIWWFFTL--IMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTA 674
            ..:|.|:...   |.|:  ::::|.||.|......:..|  |.:..|:........|.....:|.
  Fly   855 NLISERVTLA---FITITALILTSTTATLCLLFIPKLHD--IWARNDIIDPVIHSMGLKMECNTR 914

  Fly   675 AFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMES--TSIEYVTERNCEL 737
            .|..|.:.....|: ............|.:.| :.::.:       |:||  |:....|..:..|
  Fly   915 RFVVDDRRELQYRV-EVQNRVYKKEIQALDAE-IRKLER-------LLESGLTTTSTTTSSSTSL 970

  Fly   738 TQVGGMLD---TKSYGIA-TPPNSPYRTAINSVIL 768
            ...||.|.   |.:.||: ||..|..||...|.||
  Fly   971 LTGGGHLKPELTVTSGISQTPAASKNRTPSISGIL 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	89/520 (17%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	83/400 (21%)
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	79/480 (16%)
		7tmC_GABA-B-like	621..892	CDD:320175	63/319 (20%)
		TM helix 1	621..645	CDD:320175	6/26 (23%)
		TM helix 2	657..678	CDD:320175	7/20 (35%)
		TM helix 3	696..720	CDD:320175	1/23 (4%)
		TM helix 4	741..761	CDD:320175	6/28 (21%)
		TM helix 5	797..823	CDD:320175	7/28 (25%)
		TM helix 6	832..855	CDD:320175	6/32 (19%)
		TM helix 7	862..887	CDD:320175	6/27 (22%)