DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and Grik3

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	852	Identity:	400/852 - (46%)
Similarity:	577/852 - (67%)	Gaps:	49/852 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AQSLPDIIKIGGLFHPAD-------DHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFH 80
            ::.:|.:|:|||:|..||       :.:|.|||.:.:.||.:|::||.:.|...|:||...|||.
  Rat    29 SRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFE 93

  Fly    81 AGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNT 143
            |.|:.|..|.:||.|||||......:.|||||:.:|:||::.||.:..  .:::..|||||...:
  Rat    94 ATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYAS 158

  Fly   144 LSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKN 207
            ||.|.:|:|:...|::.|::|:::.|::|||||:.|.......:.:|||. ||.|.|||||::|.
  Rat   159 LSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKR 223

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN-- 270
            ..|..|:.|||.....::||||..:|||::|:.::.|:|||:.::|:.:||.|.|:||||::|
  Rat   224 GREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVD 288

  Fly   271 EKIVSDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIH 327
            ...||.:|.:||::        |.|||....:|    :.||:|||||:.:..   ...:.|:.::
  Rat   289 NPHVSAIVEKWSMERLQAAPRAESGLLDGVMMT----DAALLYDAVHIVSVC---YQRAPQMTVN 346

  Fly   328 PISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGIRKIGTWNST 391
            .:.|.....|:.|...:|::|..:.:|||..|.|:. .|.||||.|||:.|...|:.|:|.|:..
  Rat   347 SLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPA 411

  Fly   392 LPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEIS 456
              ||:|.|.....:...:..:|.|::|:|||:|..|:.|.::|...|.|||:||||.:||:.|::
  Rat   412 --DGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELA 474

  Fly   457 KSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNL 521
            ..|||:|:|:||.||.||:.:. .|:||||::||::.:||||:|.||||..||:|:||:.|||.|
  Rat   475 HILGFSYEIRLVEDGKYGAQDD-KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTL 538

  Fly   522 GVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAH----- 581
            |||||||||....|::||||:|||.|:|:|:..||||||.:||::|:|:||||   .|||
  Rat   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEW---YDAHPCNPG 600

  Fly   582 GEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVER 646
            .|.||:.|||||..||.:|||||||.:.:|||||||::.|||||||||:||||||||||||||||
  Rat   601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVER 665

  Fly   647 MDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERV 711
            |:|||:||:||||||:|:|||:|.|:|..||:.|||||:::||:|| |::||....:|.||::|.
  Rat   666 MESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQRT 729

  Fly   712 AKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776
            .  ...||.|||||:|||:|:|||.|||:||::|:|.|||.||..||||..|...||:||||.||
  Rat   730 L--TADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV 841
            ||:|.|||   ||.| |..|.:|.:||   ||:..:||:|:||..|:.::.::||.||::|.||.
  Rat   793 HIMKEKWW---RGSG-CPEEENKEASA---LGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKT 850

  Fly   842 AVEERLS 848
            |..|:.|
  Rat   851 AEREQRS 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	145/386 (38%)
		ANF_receptor	42..378	CDD:279440	132/349 (38%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	223/374 (60%)
		Lig_chan	547..823	CDD:278489	166/280 (59%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	147/391 (38%)
		ANF_receptor	55..398	CDD:279440	132/349 (38%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	224/377 (59%)
		Lig_chan	564..832	CDD:278489	166/280 (59%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1875
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	803	1.000	Inparanoid score	I470
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm44889
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780