Protein Alignment KaiR1D and Grik3

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001106187.1
• Gene: Grik3 / 298521
• RGDID: 71027
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 852
• Identity: 400/852 - (46%)
• Similarity: 577/852 - (67%)
• Gaps: 49/852 - (5%)

  Fly    23 AQSLPDIIKIGGLFHPAD-------DHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFH 80
            ::.:|.:|:|||:|..||       :.:|.|||.:.:.||.:|::||.:.|...|:||...|||.
  Rat    29 SRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFE 93

  Fly    81 AGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNT 143
            |.|:.|..|.:||.|||||......:.|||||:.:|:||::.||.:..  .:::..|||||...:
  Rat    94 ATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYAS 158

  Fly   144 LSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKN 207
            ||.|.:|:|:...|::.|::|:::.|::|||||:.|.......:.:|||. ||.|.|||||::|.
  Rat   159 LSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKR 223

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN-- 270
            ..|..|:.|||.....::||||..:|||::|:.::.|:|||:.::|:.:||.|.|:||||::|
  Rat   224 GREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVD 288

  Fly   271 EKIVSDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIH 327
            ...||.:|.:||::        |.|||....:|    :.||:|||||:.:..   ...:.|:.::
  Rat   289 NPHVSAIVEKWSMERLQAAPRAESGLLDGVMMT----DAALLYDAVHIVSVC---YQRAPQMTVN 346

  Fly   328 PISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGIRKIGTWNST 391
            .:.|.....|:.|...:|::|..:.:|||..|.|:. .|.||||.|||:.|...|:.|:|.|:..
  Rat   347 SLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPA 411

  Fly   392 LPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEIS 456
              ||:|.|.....:...:..:|.|::|:|||:|..|:.|.::|...|.|||:||||.:||:.|::
  Rat   412 --DGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELA 474

  Fly   457 KSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNL 521
            ..|||:|:|:||.||.||:.:. .|:||||::||::.:||||:|.||||..||:|:||:.|||.|
  Rat   475 HILGFSYEIRLVEDGKYGAQDD-KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTL 538

  Fly   522 GVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAH----- 581
            |||||||||....|::||||:|||.|:|:|:..||||||.:||::|:|:||||   .|||
  Rat   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEW---YDAHPCNPG 600

  Fly   582 GEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVER 646
            .|.||:.|||||..||.:|||||||.:.:|||||||::.|||||||||:||||||||||||||||
  Rat   601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVER 665

  Fly   647 MDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERV 711
            |:|||:||:||||||:|:|||:|.|:|..||:.|||||:::||:|| |::||....:|.||::|.
  Rat   666 MESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQRT 729

  Fly   712 AKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776
            .  ...||.|||||:|||:|:|||.|||:||::|:|.|||.||..||||..|...||:||||.||
  Rat   730 L--TADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV 841
            ||:|.|||   ||.| |..|.:|.:||   ||:..:||:|:||..|:.::.::||.||::|.||.
  Rat   793 HIMKEKWW---RGSG-CPEEENKEASA---LGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKT 850

  Fly   842 AVEERLS 848
            |..|:.|
  Rat   851 AEREQRS 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	146/389 (38%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	223/374 (60%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate	37..417	CDD:380605	146/388 (38%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	224/377 (59%)