Protein Alignment KaiR1D and Gria4

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_058959.2
• Gene: Gria4 / 29629
• RGDID: 61863
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 874
• Identity: 347/874 - (39%)
• Similarity: 512/874 - (58%)
• Gaps: 82/874 - (9%)

  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAV--DRINADRSILPRSKLVAQIERISPFDSFHAGKRVCG 87
            :.|..::|||||....|.:..|||.|:  ...:.:.|..| ..||..::.|...:||......|.
  Rat    22 AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAP-FNLVPHVDNIETANSFAVTNAFCS 85

  Fly    88 LLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESCLVNLYPHPNTL 144
            ..:.||.||||.....:...:.|.|..:.|..:        |:::..:||            .:|
  Rat    86 QYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLR------------PSL 138

  Fly   145 SKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD--YRPLLKQIKN 207
            ..|.:.::.|:.|..|..:|:.:.|...||.:::..|...:.::...:.:..|  ||.||:::..
  Rat   139 RGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI-- 269
            ..|...|:||..||:..:|:|...:|. :..|| |::.:|....::|:.|.:||.|:|||:|:
  Rat   204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYH-YIIANLGFKDISLERFIHGGANVTGFQLVDF 267

  Fly   270 NEKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDG 333
            |..:|:.::.:| .:|::....|.  |..:..:||.||.|.:.|:....| ..|:|||......|
  Rat   268 NTPMVTKLMDRWKKLDQREYPGSE--TPPKYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAG 329

  Fly   334 Q------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN--- 389
            .      :.|..|..:...:|.|.::|||..::|||.|.|.::.:|:.||...|.||:|.||
  Rat   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMD 394

  Fly   390 -----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAV 449
                 ..:|...|.|           |.::|:|:|||||:.:||.|.|::.....|||::|||.|
  Rat   395 KLVLIQDMPTLGNDT-----------AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCV 448

  Fly   450 DLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDF 514
            ||..||:|.:|..|||.:||||.||:.:..|..||||:.||:..:|::|||.||||..||:.:||
  Rat   449 DLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDF 513

  Fly   515 TTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTD 579
            :.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||
  Rat   514 SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW----- 573

  Fly   580 AHGEKVE-----------SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISS 633
             |.|:.|           ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||
  Rat   574 -HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISS 637

  Fly   634 YTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698
            ||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::||::|.||.||
  Rat   638 YTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPS 702

  Fly   699 VFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTA 762
            |||.:..|||.||.|.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..||.
  Rat   703 VFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTP 767

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            :|..:|||.|.|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.
  Rat   768 VNLAVLKLSEAGVLDKLKNKWWYDK---GECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAM 829

  Fly   828 VIAVCEFVWKSRKVAVEERLS---AILNE 853
            ::|:.||.:|||..|...:|:   ||.|:
  Rat   830 LVALIEFCYKSRAEAKRMKLTFSEAIRNK 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	108/398 (27%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	207/381 (54%)
Gria4	NP_058959.2	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	106/388 (27%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	210/389 (54%)