Protein Alignment KaiR1D and Gria2

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 863
• Identity: 336/863 - (38%)
• Similarity: 506/863 - (58%)
• Gaps: 78/863 - (9%)

  Fly    30 IKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVA 94
            |:|||||....|.:..|||..:.:.:..     ..:|...|:.:...:||......|...:.||.
  Rat    27 IQIGGLFPRGADQEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFAVTNAFCSQFSRGVY 86

  Fly    95 AIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYP----HP------NTLSKAYV 149
            ||||.....:.:.:.|.|..:.:              |.:...:|    ||      ..|..|.:
  Rat    87 AIFGFYDKKSVNTITSFCGTLHV--------------SFITPSFPTDGTHPFVIQMRPDLKGALL 137

  Fly   150 DIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL----SDSGD--YRPLLKQIKNS 208
            .::.::.|..|..:|:::.|:..||.:|.:.....:.:|...:    :|..|  ||.|.:.::..
  Rat   138 SLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELK 202

  Fly   209 AEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI--N 270
            .|..::|||..:::::::.|...||. :..|| |::.:|.....:|.:.::||.|::||:::  :
  Rat   203 KERRVILDCERDKVNDIVDQVITIGKHVKGYH-YIIANLGFTDGDLLKIQFGGANVSGFQIVDYD 266

  Fly   271 EKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS 335
            :.:||..:.:||..|:.....|:..|::..:||.||||.:..:|..:| ..|:|:|......|..
  Rat   267 DSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDC 330

  Fly   336 ------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN----- 389
                  .|..|..:...:|.|:::||:..||||..|.|.::.::|:||...|.||||.|:
  Rat   331 LANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395

  Fly   390 ----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVD 450
                :.||.| |.|           :.|:|||:||||||.:||.|.|::...|.||:::|||.||
  Rat   396 VVTLTELPSG-NDT-----------SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVD 448

  Fly   451 LIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFT 515
            |..||:|..||.||:.:|.||.||:.:..|..||||:.||:..:||:|||.||||..||:.:||:
  Rat   449 LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS 513

  Fly   516 TPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDA 580
            .|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||......
  Rat   514 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE 578

  Fly   581 HGEKVES-----QFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAA 640
            .|.:.:|     :|.:.|.:||::|:.|:||||..|::||.|:|.|:|||||||:||||||||||
  Rat   579 DGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 643

  Fly   641 FLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNG 705
            |||||||.|||||||||:|||.|.||.|..|||..|||.|||:.:.:||::|.||.||||..:..
  Rat   644 FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708

  Fly   706 EGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILK 769
            |||.||.|.||.||:|:|||..||:.:|. |:..:|||.||:|.||||||..|...|.:|..:||
  Rat   709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLK 773

  Fly   770 LQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEF 834
            |.|:|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.::|:.||
  Rat   774 LSEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835

  Fly   835 VWKSRKVAVEERLSAILN 852
            .:|||  |..:|:....|
  Rat   836 CYKSR--AEAKRMKVAKN 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	102/402 (25%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	204/375 (54%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	98/390 (25%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	207/383 (54%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877