Protein Alignment KaiR1D and GRIN2D

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_000827.2
• Gene: GRIN2D / 2906
• HGNCID: 4588
• Length: 1336
• Species: Homo sapiens
• Alignment Length: 919
• Identity: 210/919 - (22%)
• Similarity: 356/919 - (38%)
• Gaps: 211/919 - (22%)

  Fly     1 MRSSGVLVLPLLLLQLILNCRKAQSLP----DI---IKIGGLFHPADDHQELAFRQAVDRINADR 58
            :||.|:.|.|   :.|:||....:||.    |:   :::.|:.. .||.:..|....:|.::|..
Human    77 VRSPGLDVRP---VALVLNGSDPRSLVLQLCDLLSGLRVHGVVF-EDDSRAPAVAPILDFLSAQT 137

  Fly    59 SILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQ---------SSHTASHVQSICDN 114
            |:              |..:.|.          |.|.:..|:         .|.|...:|.|.:.
Human   138 SL--------------PIVAVHG----------GAALVLTPKEKGSTFLQLGSSTEQQLQVIFEV 178

  Fly   115 MEIPHLENRWDYRLRRESCLVNLYP-HPNTLSKAYVDIVRHW---GWKTFTIIYENNDGIVRLQE 175
            :|        :|.......:....| |...||  |::::...   ||:        :.|.:.|
Human   179 LE--------EYDWTSFVAVTTRAPGHRAFLS--YIEVLTDGSLVGWE--------HRGALTL-- 223

  Fly   176 LLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHI-VLDCSTERIHEVLKQAQQIGMMSDYH 239
                              |.|....:|.....|..|.| :|.|:.|....|.:.|::.|:....:
Human   224 ------------------DPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGY 270

  Fly   240 SYLVTSLDLHTVNLDEFRYGGTNITG---------------FRLINEKIVSDVVRQ--WSIDEKG 287
            .:.:....|       ...||:...|               |          .||.  |..|...
Human   271 VWFMVGPQL-------AGGGGSGAPGEPPLLPGGAPLPAGLF----------AVRSAGWRDDLAR 318

  Fly   288 LLRSANLTTVRSETALMYDAVHLFAKAL-HDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVE 351
            .:.:......|...||:.|  :.|...| ||             |..|:....|.||..|...:.
Human   319 RVAAGVAVVARGAQALLRD--YGFLPELGHD-------------CRAQNRTHRGESLHRYFMNIT 368

  Fly   352 MKGLTNVIKFDHQGFRTDFMLDIVELT-PAGIRKIGTW-NSTLPDGINFTRTFSQKQQEIEANLK 414
            ..  .....|:..||..:..|.::.|| ......:|:| ..||.........:.:..|.::   .
Human   369 WD--NRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVD---D 428

  Fly   415 NKTLVVTTILSNPYCMRKESAIPLSG---------NDQF------------------EGYAVDLI 452
            .:.|.|.|:...|:.: .|.|.|:||         ..|.                  :|:.:|::
Human   429 TQHLTVATLEERPFVI-VEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDIL 492

  Fly   453 HEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTP 517
            ..::.::||:|.:.||.:|.:|  .|:.|.|||||.|:..||||:||..|||..||.:.|||:.|
Human   493 KRLAHTIGFSYDLYLVTNGKHG--KKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVP 555

  Fly   518 FMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLG-VSVLLFILAKFTPYEWPAYTDA 580
            |:..|:|::. |......|:  :||.|.|..||:.|....|. |:|.:||....:|..:......
Human   556 FVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLAT 618

  Fly   581 HGEKVESQFTLLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTV 644
            ......|.||:...:|.....:....... .|:..:::::..:|.||.:|.::|||||||||:..
Human   619 GKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 683

  Fly   645 ERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFM-ESARPSVFTA 702
            |.....:....|...|      ..:|:|.:..|||....|    |.|..|.|:| ...:|.|
Human   684 EEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIR----SNYPDMHSYMVRYNQPRV--- 741

  Fly   703 SNGEGVERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPNSPYRTAI 763
              .|.:.::..||.. ||:.::..:.|:..::  |:|..:|.  :..|..||||....|.::..|
Human   742 --EEALTQLKAGKLD-AFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPI 803

  Fly   764 NSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACV 828
            :..:|:...:.::.:|:..|.     .|.|  ...|....:::|.:.|:.|||.:|:..||::.:
Human   804 DLALLQFLGDDEIEMLERLWL-----SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLL 861

  Fly   829 IAVCEFVWK 837
            :    |.|:
Human   862 V----FAWE 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	72/402 (18%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	113/410 (28%)
GRIN2D	NP_000827.2	PBP1_iGluR_NMDA_NR2	49..413	CDD:380601	83/435 (19%)
		PBP2_iGluR_NMDA_Nr2	430..830	CDD:270436	115/421 (27%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960	631..650		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..934
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1123
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1225..1336
		PDZ-binding. /evidence=ECO:0000250	1334..1336