Protein Alignment KaiR1D and GRIN1

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001424259.1
• Gene: GRIN1 / 2902
• HGNCID: 4584
• Length: 959
• Species: Homo sapiens
• Alignment Length: 936
• Identity: 229/936 - (24%)
• Similarity: 394/936 - (42%)
• Gaps: 171/936 - (18%)

  Fly    11 LLLLQLILNCRKAQSL--PDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERI 73
            ||.|.|:.:|..|::.  |.|:.||.:. ....|::: ||:||::.| .|....:.:|.|.....
Human     6 LLTLALLFSCSVARAACDPKIVNIGAVL-STRKHEQM-FREAVNQAN-KRHGSWKIQLNATSVTH 67

  Fly    74 SPFDSFHAGKRVC-GLLNIGVAAIF-----GPQSSHTASHVQSICDNMEIPHLENRWDYRLRRES 132
            .| ::......|| .|::..|.||.     .|....|.:.|........||.|.......:..:.
Human    68 KP-NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDK 131

  Fly   133 CL-------VNLYPHPNTLSKAYVDIVRHWGWKTFTII----YENNDGIVRLQELL--------- 177
            .:       |..|.|.   |..:.:::|.:.|....::    :|......||:.||
Human   132 SIHLSFLRTVPPYSHQ---SSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKSKK 193

  Fly   178 -----------------KAHGMTPFPITVRQLSDSG--DYRPLLKQIKNSAEAHIVLDCSTERIH 223
                             ||..:..|        |.|  :...||.:.|......|:|..|.:...
Human   194 RNYENLDQLSYDNKRGPKAEKVLQF--------DPGTKNVTALLMEAKELEARVIILSASEDDAA 250

  Fly   224 EVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGL 288
            .|.:.|..:.|....:.:||...:   ::.:..||....|.|.:|||.|
Human   251 TVYRAAAMLNMTGSGYVWLVGERE---ISGNALRYAPDGILGLQLINGK---------------- 296

  Fly   289 LRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQST-WQHG--FSLINYMKIV 350
                      :|:|.:.|||.:.|:|:|:|...:.|...|..|.|.:. |:.|  |..: .|...
Human   297 ----------NESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRV-LMSSK 350

  Fly   351 EMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNST----------LPDGINFTRTFSQK 405
            ...|:|..::|:..|.|......|:.|....:.::|.:|.|          .|.|    .|...:
Human   351 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGG----ETEKPR 411

  Fly   406 QQEIEANLKNKTL------VVTTILSNPYCMRK--------ESAIPLSGNDQFE----------- 445
            ..::...||..|:      .|...||:..|..:        :..|....||...
Human   412 GYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCC 476

  Fly   446 -GYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTG----EWNGMIRELLEQRADLAIADLTIT 505
             |:.:||:.::::::.|.|::.||.||.:|:..::..    |||||:.|||..:||:.:|.|||.
Human   477 YGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTIN 541

  Fly   506 FEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFT 570
            .||.|.::|:.||...|::||.:|.|.: ..|.||:.|....:|:.:..:...|:|:|::|.:|:
Human   542 NERAQYIEFSKPFKYQGLTILVKKEIPR-STLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFS 605

  Fly   571 PYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGC-DFLPKALSTRMVAGIWWFFTLIMISSY 634
            |:  ..:.....|:.|...||.:.|||:.|.|:..|. :..|::.|.|::..:|..|.:|:::||
Human   606 PF--GRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY 668

  Fly   635 TANLAAFLTVERMDSPIESAEDLAKQTRIK-------YGALKGGSTAAFF-RDSKISTYQRMWSF 691
            ||||||||.::|.:..|....|    .|::       |..:|..|...:| |..::||   |:..
Human   669 TANLAAFLVLDRPEERITGIND----PRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRH 726

  Fly   692 MESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPN 756
            ||...    ..|..|.::.|...| .:||:.:|..:|:...:.|:|...|.:.....:||....:
Human   727 MEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKD 786

  Fly   757 SPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMG 821
            ||::..::..|||..|.|.:..|...|.:.:        |....|:|...|...|:.|||:::.|
Human   787 SPWKQNVSLSILKSHENGFMEDLDKTWVRYQ--------ECDSRSNAPATLTFENMAGVFMLVAG 843

  Fly   822 GMGVACVIAVCEFVWKSRKVAVEERL 847
            |:.....:...|..:|..|.|..:::
Human   844 GIVAGIFLIFIEIAYKRHKDARRKQM 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	88/426 (21%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	116/408 (28%)
GRIN1	NP_001424259.1	None