DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and GRIK5

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	868	Identity:	353/868 - (40%)
Similarity:	526/868 - (60%)	Gaps:	58/868 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLQLIL-----NCRKAQSLPDIIKIGGLFHPADDH------QELAFRQAVDRINADRSILPRSK 65
            |||.||:     :|:...||    ::..:.   ||.      :.||...|.::||....:..:::
Human     5 LLLLLIVAFASPSCQVLSSL----RMAAIL---DDQTVCGRGERLALALAREQINGIIEVPAKAR 62

  Fly    66 LVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSS-HTASHVQSICDNMEIPHLE------NR 123
            :...|..:.....:.....:|.:|..||.::.||.|| .:||.|..||...||||::      .|
Human    63 VEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPR 127

  Fly   124 WDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT 188
            ..| ||..|  |:|||....:|.|...|::.:.:.:.::|....:.::||:||::...::...::
Human   128 LQY-LRFAS--VSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLS 189

  Fly   189 VRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNL 253
            ||.|.||.|..||||:|::...:.|::|.:....|.:|::|.::||.|.::.|::|::|...::|
Human   190 VRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHL 254

  Fly   254 DEFRYGGTNITGFRLIN--EKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALH 316
            |......:||.||.:.|  .....:.||..::..:....::.........|||:||||:...|:.
Human   255 DGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVR 319

  Fly   317 DLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAG 381
            :|:.||:|.:.|::|...:.|.||.||:||:::||..|||..::|:.:|.||::.|.|:|.:..|
Human   320 ELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQG 384

  Fly   382 IRKIGTWNSTLPDGINFTRTFSQKQQEIEANLK----NKTLVVTTILSNPYCMRKESAIPLSGND 442
            .|:||.|.|        .||.:.....::.||.    ||||||||||.|||.||:.:...||||:
Human   385 HREIGVWYS--------NRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNE 441

  Fly   443 QFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELL-EQRADLAIADLTITF 506
            :|||:.||::.|:::.|.|.|:::||.||.||: .:..|.|.||:.||: .|:||||:|..|||.
Human   442 RFEGFCVDMLRELAELLRFRYRLRLVEDGLYGA-PEPNGSWTGMVGELINRQKADLAVAAFTITA 505

  Fly   507 EREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTP 571
            |||:.:||:.|||.||:|||||..:.:.|..||||.|.|..||::|..|||.||.:||:.|:.:|
Human   506 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSP 570

  Fly   572 YEW----PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMIS 632
            |||    |... |....:|:|:||.|.:||.:|..||||.:.:|:|||||.|:|:||.||||:||
Human   571 YEWYNPHPCLR-ARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIIS 634

  Fly   633 SYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARP 697
            ||||||||||||:||:.|:|||:|||.||.|:||.:..|||..||::|:..||||||::|:|.:|
Human   635 SYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQP 699

  Fly   698 SVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTA 762
            |||..|..||:.||...:  ||||:|||..||....||.|||:||:||||.|||..|..||:|..
Human   700 SVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDE 762

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            |...||:|||..:|.|||.|||:    ||:|..|   ....|..||:.|:||:|:||:.|:.:|.
Human   763 ITLAILQLQENNRLEILKRKWWE----GGRCPKE---EDHRAKGLGMENIGGIFIVLICGLIIAV 820

  Fly   828 VIAVCEFVWKSRKVAVEERLSAI 850
            .:||.||:|.:|:.|..|...|:
Human   821 FVAVMEFIWSTRRSAESEETPAL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	112/380 (29%)
		ANF_receptor	42..378	CDD:279440	104/350 (30%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	204/374 (55%)
		Lig_chan	547..823	CDD:278489	147/279 (53%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	114/387 (29%)
		ANF_receptor	42..379	CDD:279440	103/339 (30%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	204/374 (55%)
		Lig_chan	546..816	CDD:278489	147/279 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860