Protein Alignment KaiR1D and GRIK4

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 860
• Identity: 345/860 - (40%)
• Similarity: 517/860 - (60%)
• Gaps: 55/860 - (6%)

  Fly     3 SSGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQE------LAFRQAVDRINADRSIL 61
            |:.:::||..|:.:..:       |..::|..:.   ||..|      |:...|.:|||.....|
Human     5 SAPLVLLPAWLVMVACS-------PHSLRIAAIL---DDPMECSRGERLSITLAKNRINRAPERL 59

  Fly    62 PRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASH-VQSICDNMEIPHL----E 121
            .::|:...|..:.....:...:.:|.:|..||.|:.||.||..:|. :.:||...|:||.    |
Human    60 GKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPE 124

  Fly   122 NRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFP 186
            ....::.:|.:.| ||:|....:|.|...|:..:...|..:|....:.::.|::||:...::...
Human   125 EFVKFQFQRFTTL-NLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDT 188

  Fly   187 ITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTV 251
            ::||.|.|:.|..||||:|::...|.|::..:....|.:|.:|.::||:|.|::|:.|:|:....
Human   189 LSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQ 253

  Fly   252 NLDEFRYGGTNITGFRLIN------EKIVSDVVRQW--SIDEKGLLRSANLTTVRSETALMYDAV 308
            .:|.......||.||.:.|      ::....:.:.|  :.|.      ...|.....:||::|||
Human   254 RMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDH------VPFTGPALSSALLFDAV 312

  Fly   309 HLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLD 373
            :....|:.:|:.||:|.:.|:||.....||||.||:||:::||::|||..|:|:.:|.|:::.|.
Human   313 YAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALK 377

  Fly   374 IVELTPAGIRKIGTWNSTLPDGINF-TRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIP 437
            |::.|..|.|:||.|:  :.:|::. :..::   ..|...|.|.||||||||.|||.|.|.:...
Human   378 ILQFTRNGFRQIGQWH--VAEGLSMDSHLYA---SNISDTLFNTTLVVTTILENPYLMLKGNHQE 437

  Fly   438 LSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADL 502
            :.|||::||:.||::.|:::.|.|||||:||.||.|| :.:..|.|.||:.||:.::||||:|.|
Human   438 MEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVGELIARKADLAVAGL 501

  Fly   503 TITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILA 567
            |||.|||:.:||:.|||.||:|||||..:.:.|..||||.|.|..||::|..|||.||.:||::|
Human   502 TITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   568 KFTPYEW-PAYTDAHG--EKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLI 629
            :.||||| ..:..|.|  ..:.:|::|.|.:||.:|..||||....|:|||||.|:|:||.||||
Human   567 RLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLI 631

  Fly   630 MISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMES 694
            :||||||||||||||:|||.||||.:|||.||.|:||.:.|||:..||::|:..||||||::|.|
Human   632 IISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYS 696

  Fly   695 ARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPY 759
            .:||||..|..||:.||.  ..:||||:|||..||..:|||.|||:||:||||.|||..|..|.:
Human   697 KQPSVFVKSTEEGIARVL--NSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVF 759

  Fly   760 RTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMG 824
            |...:..||:|||..:|.|||.|||:    ||||..|   ....|..||:.|:||:||||:.|:.
Human   760 RDEFDLAILQLQENNRLEILKRKWWE----GGKCPKE---EDHRAKGLGMENIGGIFVVLICGLI 817

  Fly   825 VACVIAVCEFVWKSR 839
            ||..:|:.||:|..|
Human   818 VAIFMAMLEFLWTLR 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	111/388 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	203/372 (55%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	111/389 (29%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	203/372 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956