Protein Alignment KaiR1D and GRIK3

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 852
• Identity: 402/852 - (47%)
• Similarity: 578/852 - (67%)
• Gaps: 49/852 - (5%)

  Fly    23 AQSLPDIIKIGGLFHPAD-------DHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFH 80
            ::.:|.:|:|||:|..||       :.:|.|||.:.:.||.:|::||.:.|...|:||...|||.
Human    29 SRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFE 93

  Fly    81 AGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNT 143
            |.|:.|..|.:||.|||||......:.|||||:.:|:||::.||.:..  .:::..|||||...:
Human    94 ATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYAS 158

  Fly   144 LSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKN 207
            ||.|.:|:|::..|::.|::|:::.|::|||||:.|.......:.:|||. ||.|.|||||::|.
Human   159 LSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKR 223

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN-- 270
            ..|..|:.|||.....::||||..:|||::|:.::.|:|||:.::|:.:||.|.|:||||::|
Human   224 GREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVD 288

  Fly   271 EKIVSDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIH 327
            ...||.:|.:||::        |.|||....:|    :.||:|||||:.:..   ...:.|:.::
Human   289 NPHVSAIVEKWSMERLQAAPRSESGLLDGVMMT----DAALLYDAVHIVSVC---YQRAPQMTVN 346

  Fly   328 PISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGIRKIGTWNST 391
            .:.|.....|:.|...:|::|..:.:|||..|.|:. .|.||||.|||:.|...|:.|:|.|:..
Human   347 SLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPA 411

  Fly   392 LPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEIS 456
              ||:|.|.....:...:..:|.|::|:|||:|..|:.|.::|...|.|||:||||.:||:.|::
Human   412 --DGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELA 474

  Fly   457 KSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNL 521
            ..|||:|:|:||.||.||:.:. .|:||||::||::.:||||:|.||||..||:|:||:.|||.|
Human   475 HILGFSYEIRLVEDGKYGAQDD-KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTL 538

  Fly   522 GVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAH----- 581
            |||||||||....|::||||:|||.|:|:|:..||||||.:||::|:|:||||   .|||
Human   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEW---YDAHPCNPG 600

  Fly   582 GEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVER 646
            .|.||:.|||||..||.:|||||||.:.:|||||||::.|||||||||:||||||||||||||||
Human   601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVER 665

  Fly   647 MDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERV 711
            |:|||:||:||||||:|:|||:|.|:|..||:.|||||:::||:|| |::||....:|.||::|.
Human   666 MESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQRA 729

  Fly   712 AKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776
            .  ...||.|||||:|||||:|||.|||:||::|:|.|||.||..||||..|...||:||||.||
Human   730 L--TADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV 841
            ||:|.|||   ||.| |..|.:|.:||   ||:..:||:|:||..|:.::.::||.|||:|.||.
Human   793 HIMKEKWW---RGSG-CPEEENKEASA---LGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKT 850

  Fly   842 AVEERLS 848
            |..|:.|
Human   851 AEREQRS 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	146/389 (38%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	224/374 (60%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	146/388 (38%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	225/377 (60%)