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Protein Alignment KaiR1D and GRIK2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	880	Identity:	415/880 - (47%)
Similarity:	602/880 - (68%)	Gaps:	51/880 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLPLL----------LLQLILNCRKAQSLPDIIKIGGLFHPADD----HQELAFRQAVDRINAD 57
            ::.|:|          ||..:|....:|....:::.||:|...:.    .:|||||.||:.||.:
Human     3 IIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRN 67

  Fly    58 RSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLEN 122
            |::||.:.|....::|:.:|||.|.|:.|..|::||||||||..|.:|:.|||||:.:.:||::.
Human    68 RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQT 132

  Fly   123 RWDYRL--RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPF 185
            ||.:::  .::|..|:|||..::||:|.:|:|:.:.|||.|::|:::.|::|||||:||......
Human   133 RWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNL 197

  Fly   186 PITVRQL-SDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLH 249
            .:.:||| :|:.|.:||||::|...|.|::.|||.|....:||||..:|||::|:.|:.|:|||.
Human   198 RLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLF 262

  Fly   250 TVNLDEFRYGGTNITGFRLINEK--IVSDVVRQWSID--------EKGLLRSANLTTVRSETALM 304
            .::::.:||.|.|:||||::|.:  .||.::.:||::        :.||| ...:||   :.|||
Human   263 ALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLL-DGFMTT---DAALM 323

  Fly   305 YDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRT 368
            |||||:.:.|:...   .|:.:..:.|:....|:.|...::.:|....:|||..|.|:. .|.||
Human   324 YDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRT 385

  Fly   369 DFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKE 433
            ||.||::.|...|:.|||||:..  .|:|.|.:...|...|..:|.|::|:|||||..||.:.|:
Human   386 DFDLDVISLKEEGLEKIGTWDPA--SGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448

  Fly   434 SAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLA 498
            |..||.|||:||||.:||:.|:|..|||.|:|:||.||.||:.:...|:||||:|||::.:||||
Human   449 SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLA 513

  Fly   499 IADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLL 563
            :|.|.||:.||:.:||:.|||.||:|||||||....|.:||||:|||.|:|:|:..||||||.:|
Human   514 VAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVL 578

  Fly   564 FILAKFTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFF 626
            |::|:|:||||  |...:...:.||:.|||||..||.:|:|||||.:.:|||||||:|.||||||
Human   579 FVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFF 643

  Fly   627 TLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSF 691
            |||:|||||||||||||||||:|||:||:||||||:|:|||::.|:|..||:.||||||.:||:|
Human   644 TLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAF 708

  Fly   692 MESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPN 756
            |.|.|.||...||.||::||.  ...||||||||:||:||:|||.|||:||::|:|.||:.||..
Human   709 MSSRRQSVLVKSNEEGIQRVL--TSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMG 771

  Fly   757 SPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMG 821
            ||||..|...||:||||||||::|.|||   ||.| |..|.||.:||   ||:.|:||:|:||..
Human   772 SPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEEESKEASA---LGVQNIGGIFIVLAA 829

  Fly   822 GMGVACVIAVCEFVWKSRKVA-VEER--LSAILNE 853
            |:.::..:||.||::||:|.| :|:|  .||::.|
Human   830 GLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEE 864

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.