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Protein Alignment KaiR1D and GRIK1

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	852	Identity:	413/852 - (48%)
Similarity:	574/852 - (67%)	Gaps:	54/852 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QSLPDIIKIGGLFHPADDH----QELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKR 84
            |:.|.:::|||:|...::.    :||||:.||..||.:|:::|.:.|...|:||:.||||.|.:|
Human    31 QTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRR 95

  Fly    85 VCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNTLSKA 147
            .|..|.:||||:|||..|.:.|.|||||:.:|:||::.||.:..  .::...:||||....:|:|
Human    96 ACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRA 160

  Fly   148 YVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL-SDSGDYRPLLKQIKNSAEA 211
            .:|:|.::.|||.|::||::.|::|||||:||.......|.:||| |.:.|.:||||::|...|.
Human   161 ILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEF 225

  Fly   212 HIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIV 274
            :::.|||.|...|:|||...:|||::|:.|..|:|||..::|:.:||.|.|:|||||:|  ...|
Human   226 YVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHV 290

  Fly   275 SDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISC 331
            |.::.:||::        |.||| ...:||   |.|||||||::.|.|.|   .:.|:.:..:.|
Human   291 SSIIEKWSMERLQAPPRPETGLL-DGMMTT---EAALMYDAVYMVAIASH---RASQLTVSSLQC 348

  Fly   332 DGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGI------------- 382
            .....|:.|...:|.:|.....|||..|.|:. .|.|.||.|||:.|...|.
Human   349 HRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYK 413

  Fly   383 --RKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFE 445
              :|||.|||.  .|:|.|.:...|...|..:|.|:||:|||||..||.|.::|..||.|||:||
Human   414 VWKKIGIWNSN--SGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFE 476

  Fly   446 GYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQ 510
            ||.:||:.|:|..|||.|.::|||||.||:.|. .||||||::||::.|||||:|.||||:.||:
Human   477 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVAPLTITYVREK 540

  Fly   511 AVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW- 574
            .:||:.|||.||:|||||||....|.:||||:|||.|:|:|:..|.||||.:||::|:||||||
Human   541 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY 605

  Fly   575 -PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANL 638
             |...:...:.||:.|||||..||.:|:|||||.:.:|||||||:|.|||||||||:||||||||
Human   606 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 670

  Fly   639 AAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTAS 703
            |||||||||:|||:||:||||||:|:|||::.|||..||:.||||||::||:||.|.:.:....:
Human   671 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 735

  Fly   704 NGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVIL 768
            :.||::||.  ...||.|||||||||||:|||.|||:||::|:|.||:.||..||||..|...||
Human   736 SDEGIQRVL--TTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAIL 798

  Fly   769 KLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCE 833
            :||||||||::|.|||   ||.| |..|.:|.:||   ||:.|:||:|:||..|:.::..:|:.|
Human   799 QLQEEGKLHMMKEKWW---RGNG-CPEEDNKEASA---LGVENIGGIFIVLAAGLVLSVFVAIGE 856

  Fly   834 FVWKSRK 840
            |::||||
Human   857 FIYKSRK 863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.