Protein Alignment KaiR1D and GRID2

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 941
• Identity: 270/941 - (28%)
• Similarity: 426/941 - (45%)
• Gaps: 205/941 - (21%)

  Fly    28 DIIKIGGLFHPADDH----QELAFRQAVDRINADRSILPRSKLVAQIE-----------RISPFD 77
            |.:..|||:|.....    |.|...:...|:.....::.||.:.|...           ..||..
Human    24 DFVSRGGLYHVQGSSDLVTQVLWPSRVSQRVFCSVMVVVRSGVTAATRMPLRETRGTNTTASPAT 88

  Fly    78 SFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL------------------ENR- 123
            :.  .::.|.|:|.|:.|:.......:|..:||:.|.|.||||                  .||
Human    89 AL--PQKTCELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRN 151

  Fly   124 WDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT 188
            .||.|       ::.| |..|....:.:|..:.|:.|.|.|::...|..:||.|.
Human   152 DDYTL-------SVRP-PVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD---------- 198

  Fly   189 VRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEV------LKQAQQIGMMSDYHSYLVTSLD 247
              ::|..| ....|::::|:....|.....|.||.|:      |::|..:...:...|::...::
Human   199 --KVSQQG-MDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVE 260

  Fly   248 LHTVNLDEFRYGGTNITGFR----LINEKI----VSDVVRQWSIDEKGLLR-------------- 290
                         ||:..|.    :|||:|    |.::||: ||....::|
Human   261 -------------TNLVAFDCHWIIINEEINDVDVQELVRR-SIGRLTIIRQTFPVPQNISQRCF 311

  Fly   291 ------SANLTTVRSETA--------LMYDAVHLFAKALH-DLDTSQQIDIHPISC--DGQSTWQ 338
                  |:.|...:...|        .:||.|.|.|.|.| .|:..:...:..:||  .....||
Human   312 RGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQ 376

  Fly   339 HGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIV-----ELTPAGIRK-------------- 384
            .|.|::..:|...:.|||..::|...|...:...:|:     |....|:||
Human   377 GGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKNERIRPQGSTGKIW 441

  Fly   385 --IGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGY 447
              :|.||..  .|:|.:.|    .:::|.|::...|.|.|:|..|:.|..|:.  |....:::|:
Human   442 PQLGCWNPV--TGLNGSLT----DKKLENNMRGVVLRVVTVLEEPFVMVSENV--LGKPKKYQGF 498

  Fly   448 AVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAV 512
            ::|::..:|..|||||:|.:.||..|||..: .|.|||::.||:.:|||:.|:.||||.:||..|
Human   499 SIDVLDALSNYLGFNYEIYVAPDHKYGSPQE-DGTWNGLVGELVFKRADIGISALTITPDRENVV 562

  Fly   513 DFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTP--YEWP 575
            ||||.:|:..|.:|.|: .::..::|:.|:|..|.:|..:|...|.|.:|:::|....|  .:..
Human   563 DFTTRYMDYSVGVLLRR-AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMG 626

  Fly   576 AYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAA 640
            :.|..         ||.|.|||..||.:|||.:.....|:|||:.|.||.|.||:||||||||||
Human   627 SMTST---------TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAA 682

  Fly   641 FLTVERMDSPIESAEDLAKQTRIKYGA-----------LKGGSTAAFFRDSKISTYQRMWSFMES 694
            |||:.|::|.|:|.:||:|||.|.||.           :||  ...|.||   |.|.:||
Human   683 FLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKG--LNPFERD---SMYSQMW----- 737

  Fly   695 ARPSVFTASNGE---------GVERVAKGKGSYAFLMESTSIEYV--TERNCELTQVGGMLDTKS 748
               .:...|||.         |:::|.  .|:|||:.::..:|||  .:.:|....:|..:..:.
Human   738 ---RMINRSNGSENNVLESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRG 797

  Fly   749 YGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKC----RVETSKSSSAANELGL 809
            ||||....||||...:..||:||:.|.:.|||.|||.:   .|:|    .|:|.:...|   |.:
Human   798 YGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPK---NGQCDLYSSVDTKQKGGA---LDI 856

  Fly   810 ANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
            .:..|||.:|..|:.::|.||:.|..|..||
Human   857 KSFAGVFCILAAGIVLSCFIAMLETWWNKRK 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	101/468 (22%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	146/393 (37%)
GRID2	XP_011530195.2	Periplasmic_Binding_Protein_type1	92..457	CDD:471960	89/401 (22%)
		PBP2_iGluR_delta_2	468..834	CDD:270449	146/393 (37%)