DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GRID1

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	919	Identity:	274/919 - (29%)
Similarity:	447/919 - (48%)	Gaps:	110/919 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERI 73
            |.|.||..|..|...:: ..||.||.:|.......:..|:.||..::.:..||...|:...|:.|
Human     4 LTLWLLPWICQCVSVRA-DSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVI 67

  Fly    74 SPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL-ENRWDYRLRRESCLVNL 137
            ...:.|.|.:..|.|:..|:.|:.......:|:.:||:.|.|.|||| ..|......|.:|.:|.
Human    68 EANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNP 132

  Fly   138 YPH----------PNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLK-------------- 178
            .|.          |..|:...:.:|....|:.|.:.|::...|..||..|.
Human   133 SPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKV 197

  Fly   179 ----AHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMS-DY 238
                :|..|.. .|..:..:...||..|::        .:|..|.:..|..:.:|.:..:.| |.
Human   198 DKNISHVFTSL-FTTMKTEELNRYRDTLRR--------AILLLSPQGAHSFINEAVETNLASKDS 253

  Fly   239 HSYLVTS--LDLHTVNLDEFRYGGTNITGFRLI------NEKIVSDVVRQWSI---DEKGLLRSA 292
            |...|..  .|...::|.....|  .:|..|.|      |:|...:..|..|:   .::|.|:..
Human   254 HWVFVNEEISDPEILDLVHSALG--RMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQML 316

  Fly   293 NLTTVRSETALMYDAVHLFAKALH-DLDTSQQIDIHPISCDGQST--WQHGFSLINYMKIVEMKG 354
            .::.:     .:||:|.:.|.|.| .|:..:...:..::|..:||  |..|.|:::.:|...:.|
Human   317 QISNL-----YLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG 376

  Fly   355 LTNVIKFDHQGFRTDFMLDIVELTPA-----GIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLK 414
            ||.|::|...........:|:..|.:     .:||:.||:|  ..|:|    .|.:::.:.:.|:
Human   377 LTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS--EKGLN----GSLQERPMGSRLQ 435

  Fly   415 NKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKL 479
            ..||.|.|:|..|:.|..|:.  |....:::|:::|::..::|:|||.|:|...|||.||.....
Human   436 GLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHN 498

  Fly   480 TGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPL 544
            | .|||||.||:.:||||||:.:|||.|||..|||:..:|:..|.||.:|| ::..::||..:|.
Human   499 T-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPF 561

  Fly   545 SLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDF 609
            ...||..:|.|...|.||:|:|.:.....   ...|...:..:..||.:.:|...|:.:|||.:.
Human   562 DFAVWACIAAAIPVVGVLIFVLNRIQAVR---AQSAAQPRPSASATLHSAIWIVYGAFVQQGGES 623

  Fly   610 LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTA 674
            ...:::.|:|.|.||.||||:.|||||||||||||.|||:||.:.:||:||..:.||.::..:..
Human   624 SVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVY 688

  Fly   675 AFFRD------SKISTYQRMW-SFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEY--V 730
            .:||.      .:.||:..:| :..::.......:|..||: |.|| ||:||||.:...:||  :
Human   689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGI-RKAK-KGNYAFLWDVAVVEYAAL 751

  Fly   731 TERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRV 795
            |:.:|.:|.:|..:.:|.||||....||||...:..||:||:.|.|.:||.|||...   |:|.:
Human   752 TDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHM---GRCDL 813

  Fly   796 ETSKSSSAAN--ELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV--------------AVE 844
             ||.:|:.|:  .|.|.:..|||.:|..|:.:||::|..|..|.|.:.              .|.
Human   814 -TSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVH 877

  Fly   845 ERLSAILNE 853
            .|::::::|
Human   878 RRMNSLMDE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	94/414 (23%)
		ANF_receptor	42..378	CDD:279440	84/379 (22%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	146/378 (39%)
		Lig_chan	547..823	CDD:278489	105/286 (37%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		99/436 (23%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	95/419 (23%)
		ANF_receptor	41..400	CDD:279440	84/374 (22%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	146/378 (39%)
		Lig_chan	564..841	CDD:278489	105/285 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810