Protein Alignment KaiR1D and GRIA4

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 874
• Identity: 347/874 - (39%)
• Similarity: 511/874 - (58%)
• Gaps: 82/874 - (9%)

  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAV--DRINADRSILPRSKLVAQIERISPFDSFHAGKRVCG 87
            :.|..::|||||....|.:..|||.|:  ...:.:.|..| ..||..::.|...:||......|.
Human    22 AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAP-FNLVPHVDNIETANSFAVTNAFCS 85

  Fly    88 LLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESCLVNLYPHPNTL 144
            ..:.||.||||.....:...:.|.|..:.|..:        |:::..:||            .:|
Human    86 QYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLR------------PSL 138

  Fly   145 SKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD--YRPLLKQIKN 207
            ..|.:.::.|:.|..|..:|:.:.|...||.:::..|...:.::...:.:..|  ||.||:::..
Human   139 RGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI-- 269
            ..|...|:||..||:..:|:|...:|. :..|| |::.:|....::|:.|.:||.|:|||:|:
Human   204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYH-YIIANLGFKDISLERFIHGGANVTGFQLVDF 267

  Fly   270 NEKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDG 333
            |..:|..::.:| .:|::....|.  |..:..:||.||.|.:.|:....| ..|:|||......|
Human   268 NTPMVIKLMDRWKKLDQREYPGSE--TPPKYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAG 329

  Fly   334 Q------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN--- 389
            .      :.|..|..:...:|.|.::|||..::|||.|.|.::.:|:.||...|.||:|.||
Human   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMD 394

  Fly   390 -----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAV 449
                 ..:|...|.|           |.::|:|:|||||:.:||.|.|::.....|||::|||.|
Human   395 KLVLIQDVPTLGNDT-----------AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCV 448

  Fly   450 DLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDF 514
            ||..||:|.:|..|||.:||||.||:.:..|..||||:.||:..:|::|||.||||..||:.:||
Human   449 DLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDF 513

  Fly   515 TTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTD 579
            :.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||
Human   514 SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW----- 573

  Fly   580 AHGEKVE-----------SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISS 633
             |.|:.|           ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||
Human   574 -HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISS 637

  Fly   634 YTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698
            ||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::||::|.||.||
Human   638 YTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPS 702

  Fly   699 VFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTA 762
            |||.:..|||.||.|.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..||.
Human   703 VFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTP 767

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            :|..:|||.|.|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.
Human   768 VNLAVLKLSEAGVLDKLKNKWWYDK---GECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAM 829

  Fly   828 VIAVCEFVWKSRKVAVEERLS---AILNE 853
            ::|:.||.:|||..|...:|:   ||.|:
Human   830 LVALIEFCYKSRAEAKRMKLTFSEAIRNK 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	108/398 (27%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	207/381 (54%)
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	106/388 (27%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	210/389 (54%)