back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GRIA2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	863	Identity:	339/863 - (39%)
Similarity:	508/863 - (58%)	Gaps:	78/863 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVA 94
            |:|||||....|.:..|||..:.:.:..     ..:|...|:.:...:||......|...:.||.
Human    27 IQIGGLFPRGADQEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFAVTNAFCSQFSRGVY 86

  Fly    95 AIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYP----HP------NTLSKAYV 149
            ||||.....:.:.:.|.|..:.:              |.:...:|    ||      ..|..|.:
Human    87 AIFGFYDKKSVNTITSFCGTLHV--------------SFITPSFPTDGTHPFVIQMRPDLKGALL 137

  Fly   150 DIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL----SDSGD--YRPLLKQIKNS 208
            .::.::.|..|..:|:::.|:..||.:|.:.....:.:|...:    :|..|  ||.|.:.::..
Human   138 SLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELK 202

  Fly   209 AEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI--N 270
            .|..::|||..:::::::.|...||. :..|| |::.:|.....:|.:.::||.|::||:::  :
Human   203 KERRVILDCERDKVNDIVDQVITIGKHVKGYH-YIIANLGFTDGDLLKIQFGGANVSGFQIVDYD 266

  Fly   271 EKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS 335
            :.:||..:.:||..|:.....|:.||::..:||.||||.:..:|..:| ..|:|:|......|..
Human   267 DSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDC 330

  Fly   336 ------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN----- 389
                  .|..|..:...:|.|:::||:..||||..|.|.::.::|:||...|.||||.|:
Human   331 LANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395

  Fly   390 ----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVD 450
                :.||.| |.|           :.|:|||:||||||.:||.|.|::...|.||:::|||.||
Human   396 VVTLTELPSG-NDT-----------SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVD 448

  Fly   451 LIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFT 515
            |..||:|..||.||:.:|.||.||:.:..|..||||:.||:..:||:|||.||||..||:.:||:
Human   449 LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS 513

  Fly   516 TPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDA 580
            .|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||......
Human   514 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE 578

  Fly   581 HGEKVES-----QFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAA 640
            .|.:.:|     :|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:||||||||||
Human   579 DGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 643

  Fly   641 FLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNG 705
            |||||||.|||||||||:|||.|.||.|..|||..|||.|||:.:.:||::|.||.||||..:..
Human   644 FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708

  Fly   706 EGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILK 769
            |||.||.|.||.||:|:|||..||:.:|. |:..:|||.||:|.||||||..|..||.:|..:||
Human   709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLK 773

  Fly   770 LQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEF 834
            |.|:|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.::|:.||
Human   774 LSEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835

  Fly   835 VWKSRKVAVEERLSAILN 852
            .:|||  |..:|:....|
Human   836 CYKSR--AEAKRMKVAKN 851

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.