DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grin2d

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	920	Identity:	200/920 - (21%)
Similarity:	354/920 - (38%)	Gaps:	202/920 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSSGVLVLPLLLLQLILNCRKAQSLP----DI---IKIGGLFHPADDHQELAFRQAVDRINADR 58
            :||.|:.|.|   :.|:||....:||.    |:   :::.|:.. .||.:..|....:|.::|..
  Rat    74 VRSPGLDVRP---VALVLNGSDPRSLVLQLCDLLSGLRVHGVVF-EDDSRAPAVAPILDFLSAQT 134

  Fly    59 SILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENR 123
            |:              |..:.|.          |.|.:..|:
  Rat   135 SL--------------PIVAVHG----------GAALVLTPK----------------------- 152

  Fly   124 WDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT 188
                 .:.|..:.|........:...:::..:.|.:|..:            ..:|.|...|...
  Rat   153 -----EKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAV------------TTRAPGHRAFLSY 200

  Fly   189 VRQLSDSG----DYRPLLKQIKNSAEAHI------------VLDCSTERIHEVLKQAQQIGMMSD 237
            :..|:|..    ::|..|.....:.||.:            :|.|:.|....|.:.|::.|:...
  Rat   201 IEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGP 265

  Fly   238 YHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI---NEKIVSDV--VRQ--WSIDEKGLLRSANLT 295
            .:.:.:....|       ...||:.:.|..|:   ...:.:.:  ||.  |..|....:.:....
  Rat   266 GYVWFMVGPQL-------AGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAV 323

  Fly   296 TVRSETALMYDAVHLFAKAL-HDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVI 359
            ..|...||:.|  :.|...| ||             |..|:....|.||..|...:...  ....
  Rat   324 VARGAQALLRD--YGFLPELGHD-------------CRTQNRTHRGESLHRYFMNITWD--NRDY 371

  Fly   360 KFDHQGFRTDFMLDIVELT-PAGIRKIGTW-NSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTT 422
            .|:..||..:..|.::.|| ......:|:| ..||.........:.:..|.::   ..:.|.|.|
  Rat   372 SFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVD---DTQHLTVAT 433

  Fly   423 ILSNPYCMRKESAIPLSG---------NDQF------------------EGYAVDLIHEISKSLG 460
            :...|:.: .|.|.|:||         ..|.                  :|:.:|::..::.::|
  Rat   434 LEERPFVI-VEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIG 497

  Fly   461 FNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSI 525
            |:|.:.||.:|.:|  .|:.|.|||||.|:..||||:||..|||..||.:.|||:.||:..|:|:
  Rat   498 FSYDLYLVTNGKHG--KKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISV 560

  Fly   526 LYRKP--IKQPPNLFSFL--------SPLSLDVWIYMATAYLG-VSVLLFILAKFTPYEWPAYTD 579
            :..:.  ...|....:|.        .|.|..||:.|....|. |:|.:||....:|..:.....
  Rat   561 MVARSNGTVSPSAFLAFAWLTPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLA 625

  Fly   580 AHGEKVESQFTLLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLT 643
            .......|.||:...:|.....:....... .|:..:::::..:|.||.:|.::|||||||||:.
  Rat   626 TGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMI 690

  Fly   644 VERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFM-ESARPSVFT 701
            .|.....:....|...|      ..:|:|.:..|||....|    |.|..|.|:| ...:|.|
  Rat   691 QEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIR----SNYPDMHSYMVRYNQPRV-- 749

  Fly   702 ASNGEGVERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPNSPYRTA 762
               .|.:.::..||.. ||:.::..:.|:..::  |:|..:|.  :..|..||||....|.::..
  Rat   750 ---EEALTQLKAGKLD-AFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRP 810

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            |:..:|:...:.::.:|:..|.     .|.|  ...|....:::|.:.|:.|||.:|:..||::.
  Rat   811 IDLALLQFLGDDEIEMLERLWL-----SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSL 868

  Fly   828 VIAVCEFVWK 837
            ::    |.|:
  Rat   869 LV----FAWE 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	64/391 (16%)
		ANF_receptor	42..378	CDD:279440	55/359 (15%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	111/419 (26%)
		Lig_chan	547..823	CDD:278489	71/288 (25%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	75/427 (18%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	113/430 (26%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810