Protein Alignment KaiR1D and Grin2b

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 968
• Identity: 229/968 - (23%)
• Similarity: 393/968 - (40%)
• Gaps: 225/968 - (23%)

  Fly    11 LLLLQLILNCRKA--QSLPDIIKIGGLFHPADDHQELAFRQAVDRINADR-SILPRSKLVAQIER 72
            |:|..|.::..||  |..|..|.|..:.....|  |:|.:.|.::.:... |::||.:|||..|.
  Rat    14 LVLAVLAVSGSKARSQKSPPSIGIAVILVGTSD--EVAIKDAHEKDDFHHLSVVPRVELVAMNET 76

  Fly    73 ISPFDSFHAGKRVCGLLN---------------IGVAAIFGPQSSHTASHVQSI--------CDN 114
                |......|:|.|::               ..:|.|....|:.|.:.:..|        .|.
  Rat    77 ----DPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADK 137

  Fly   115 MEIPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTII------YENNDGIVR- 172
            .|              .|......|.....:...::|:..:.|..|:|:      |::....:|
  Rat   138 DE--------------SSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRS 188

  Fly   173 ----------LQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVL 226
                      |:|:|           :..:| |.||.: :..|:|......|:|.|:.|....:.
  Rat   189 TIENSFVGWELEEVL-----------LLDMSLDDGDSK-IQNQLKKLQSPIILLYCTKEEATYIF 241

  Fly   227 KQAQQIGMMSDYHSYLVTSL---DLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGL 288
            :.|..:|:....::::|.||   |..||. .||..|             ::|....:|   :.||
  Rat   242 EVANSVGLTGYGYTWIVPSLVAGDTDTVP-SEFPTG-------------LISVSYDEW---DYGL 289

  Fly   289 LRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHP-ISCDGQSTWQ---HGFSLIN-YMK 348
                        .|.:.|.:.:...|..|:.:.......| .||  .:|.:   :..:::| |:.
  Rat   290 ------------PARVRDGIAIITTAASDMLSEHSFIPEPKSSC--YNTHEKRIYQSNMLNRYLI 340

  Fly   349 IVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRK---IGTW--NSTLPDGINFTRTFSQKQQE 408
            .|..:|..  :.|...|::....|.|:.|...  ||   :|.|  .|.......:.|...:.:::
  Rat   341 NVTFEGRN--LSFSEDGYQMHPKLVIILLNKE--RKWERVGKWKDKSLQMKYYVWPRMCPETEEQ 401

  Fly   409 IEANLKNKTLVVTTILSNPYCMRKESAIPLSG------------------NDQFEGY-------- 447
            .:.:|.     :.|:...|:.: .||..||||                  .|:..||
  Rat   402 EDDHLS-----IVTLEEAPFVI-VESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGF 460

  Fly   448 AVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAV 512
            .:|::.:||||:.|.|.:.||.:|.:|  .|:.|.|||||.|::.:||.:|:..|||..||.:.|
  Rat   461 CIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVV 523

  Fly   513 DFTTPFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVS-VLLFILAKFTPYEWP 575
            ||:.||:..|:|::. |......|:  :||.|.|.|||:.|....|.|| |.:|:...|:|..:.
  Rat   524 DFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN 586

  Fly   576 AYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFL-PKALSTRMVAGIWWFFTLIMISSYTANLA 639
            .......|.....||:...:|...|.:........ ||..:::::..:|.||.:|.::|||||||
  Rat   587 RCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLA 651

  Fly   640 AFLTVERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698
            ||:..|.....:....|...|      ...::|.:..|||....|::    |..|.::|..
  Rat   652 AFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYMGK---- 708

  Fly   699 VFTASNGEGVE----RVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPP 755
                .|..||:    .:..||.. ||:.::..:.|:..|:  |:|..:|.  :..:..||||...
  Rat   709 ----FNQRGVDDALLSLKTGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQK 768

  Fly   756 NSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLM 820
            :|.::..::..||:|..:|::..|:..|..     |.|..|  |:...:::|.:.|:.|||.:|.
  Rat   769 DSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHNE--KNEVMSSQLDIDNMAGVFYMLG 826

  Fly   821 GGMGVACVIAVCE--FVWKSRK--------------------------VAVEERLSAI 850
            ..|.::.:..:||  |.|:.|.                          ||:|||.|.:
  Rat   827 AAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVM 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	81/423 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	116/412 (28%)
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	82/421 (19%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	119/427 (28%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		2/18 (11%)
		NMDAR2_C	840..1482	CDD:463148	9/45 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482