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Protein Alignment KaiR1D and Grin2b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_036706.1	Gene:	Grin2b / 24410	RGDID:	2738	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	229/968 - (23%)
Similarity:	393/968 - (40%)	Gaps:	225/968 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLQLILNCRKA--QSLPDIIKIGGLFHPADDHQELAFRQAVDRINADR-SILPRSKLVAQIER 72
            |:|..|.::..||  |..|..|.|..:.....|  |:|.:.|.::.:... |::||.:|||..|.
  Rat    14 LVLAVLAVSGSKARSQKSPPSIGIAVILVGTSD--EVAIKDAHEKDDFHHLSVVPRVELVAMNET 76

  Fly    73 ISPFDSFHAGKRVCGLLN---------------IGVAAIFGPQSSHTASHVQSI--------CDN 114
                |......|:|.|::               ..:|.|....|:.|.:.:..|        .|.
  Rat    77 ----DPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADK 137

  Fly   115 MEIPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTII------YENNDGIVR- 172
            .|              .|......|.....:...::|:..:.|..|:|:      |::....:|
  Rat   138 DE--------------SSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRS 188

  Fly   173 ----------LQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVL 226
                      |:|:|           :..:| |.||.: :..|:|......|:|.|:.|....:.
  Rat   189 TIENSFVGWELEEVL-----------LLDMSLDDGDSK-IQNQLKKLQSPIILLYCTKEEATYIF 241

  Fly   227 KQAQQIGMMSDYHSYLVTSL---DLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGL 288
            :.|..:|:....::::|.||   |..||. .||..|             ::|....:|   :.||
  Rat   242 EVANSVGLTGYGYTWIVPSLVAGDTDTVP-SEFPTG-------------LISVSYDEW---DYGL 289

  Fly   289 LRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHP-ISCDGQSTWQ---HGFSLIN-YMK 348
                        .|.:.|.:.:...|..|:.:.......| .||  .:|.:   :..:::| |:.
  Rat   290 ------------PARVRDGIAIITTAASDMLSEHSFIPEPKSSC--YNTHEKRIYQSNMLNRYLI 340

  Fly   349 IVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRK---IGTW--NSTLPDGINFTRTFSQKQQE 408
            .|..:|..  :.|...|::....|.|:.|...  ||   :|.|  .|.......:.|...:.:::
  Rat   341 NVTFEGRN--LSFSEDGYQMHPKLVIILLNKE--RKWERVGKWKDKSLQMKYYVWPRMCPETEEQ 401

  Fly   409 IEANLKNKTLVVTTILSNPYCMRKESAIPLSG------------------NDQFEGY-------- 447
            .:.:|.     :.|:...|:.: .||..||||                  .|:..||
  Rat   402 EDDHLS-----IVTLEEAPFVI-VESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGF 460

  Fly   448 AVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAV 512
            .:|::.:||||:.|.|.:.||.:|.:|  .|:.|.|||||.|::.:||.:|:..|||..||.:.|
  Rat   461 CIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVV 523

  Fly   513 DFTTPFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVS-VLLFILAKFTPYEWP 575
            ||:.||:..|:|::. |......|:  :||.|.|.|||:.|....|.|| |.:|:...|:|..:.
  Rat   524 DFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN 586

  Fly   576 AYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFL-PKALSTRMVAGIWWFFTLIMISSYTANLA 639
            .......|.....||:...:|...|.:........ ||..:::::..:|.||.:|.::|||||||
  Rat   587 RCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLA 651

  Fly   640 AFLTVERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698
            ||:..|.....:....|...|      ...::|.:..|||....|::    |..|.::|..
  Rat   652 AFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYMGK---- 708

  Fly   699 VFTASNGEGVE----RVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPP 755
                .|..||:    .:..||.. ||:.::..:.|:..|:  |:|..:|.  :..:..||||...
  Rat   709 ----FNQRGVDDALLSLKTGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQK 768

  Fly   756 NSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLM 820
            :|.::..::..||:|..:|::..|:..|..     |.|..|  |:...:::|.:.|:.|||.:|.
  Rat   769 DSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHNE--KNEVMSSQLDIDNMAGVFYMLG 826

  Fly   821 GGMGVACVIAVCE--FVWKSRK--------------------------VAVEERLSAI 850
            ..|.::.:..:||  |.|:.|.                          ||:|||.|.:
  Rat   827 AAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVM 884

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.