back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grin2a

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	222/915 - (24%)
Similarity:	366/915 - (40%)	Gaps:	213/915 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLPLLLLQLILNCRKAQSL----PDII---KIGGLFHPADDHQELAFRQAVDRINADRSILPRS 64
            |.|.:.::.|::|....:||    .|::   :|.||....|..|| |..|.:|.|::...|
  Rat    63 LPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQE-AVAQMLDFISSQTFI---- 122

  Fly    65 KLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQ---SICDNMEIPHLENRWDY 126
                      |....|.|           |::.......|::..|   ||.....: .|:...||
  Rat   123 ----------PILGIHGG-----------ASMIMADKDPTSTFFQFGASIQQQATV-MLKIMQDY 165

  Fly   127 RLRRESCLVNLYPH--------PNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMT 183
            .....|.:..::|.        ..|:..::|      ||        :...::.|.        |
  Rat   166 DWHVFSLVTTIFPGYRDFISFIKTTVDNSFV------GW--------DMQNVITLD--------T 208

  Fly   184 PFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDL 248
            .|.....|:.        ||:|.:|.   |:|.||.:....:|.:|:.:|:......::|.||..
  Rat   209 SFEDAKTQVQ--------LKKIHSSV---ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVS 262

  Fly   249 HTVNL--DEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRS--ANLTTVRSETALMYDAVH 309
            ....|  .||..|             ::|.....|....:..:|.  ..|||..|..
  Rat   263 GNTELIPKEFPSG-------------LISVSYDDWDYSLEARVRDGLGILTTAASSM-------- 306

  Fly   310 LFAKALHDLDTSQQIDIHPISCDGQS----TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDF 370
                    |:....|.....||.||:    |..|  :|..:|..|...|  ..:.|..:|::...
  Rat   307 --------LEKFSYIPEAKASCYGQAEKPETPLH--TLHQFMVNVTWDG--KDLSFTEEGYQVHP 359

  Fly   371 MLDIVELT-PAGIRKIGTW-NSTL-------PDGINFTRTFSQKQQEIEANLKNKTL-------- 418
            .|.::.|. .....|:|.| |.||       |.    .::||..:.: :.:|...||
  Rat   360 RLVVIVLNKDREWEKVGKWENQTLSLRHAVWPR----YKSFSDCEPD-DNHLSIVTLEEAPFVIV 419

  Fly   419 -----VVTTILSNPYCMRKESAIPLSGNDQF------EGYAVDLIHEISKSLGFNYKIQLVPDGS 472
                 :..|.:.|....||...|..|.|:..      :|:.:|::.::|:::.|.|.:.||.:|.
  Rat   420 EDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGK 484

  Fly   473 YGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILY-RKPIKQPPN 536
            :|  .|:...|||||.|::.|||.:|:..|||..||.:.|||:.||:..|:|::. |......|:
  Rat   485 HG--KKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   537 LFSFLSPLSLDVWIYMATAYLGVS-VLLFILAKFTPYEW---------PAYTDAHGEKVESQFTL 591
              :||.|.|..||:.|....|.|| :.:|:...|:|..:         |     ||    ..||:
  Rat   548 --AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAP-----HG----PSFTI 601

  Fly   592 LNCMWFAIGSLMQQGCDFL-PKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAE 655
            ...:|...|.:........ ||..:::::..:|.||.:|.::|||||||||:..|.....:....
  Rat   602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLS 666

  Fly   656 DLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVE----R 710
            |...|      ...::|.:..|||....|::    |..|..:|        |..|..|||    .
  Rat   667 DKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPYMHQYM--------TRFNQRGVEDALVS 719

  Fly   711 VAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPNSPYRTAINSVILKLQ 771
            :..||.. ||:.::..:.|...|:  |:|..:|.  :..|..||||....||::..|:..:|:..
  Rat   720 LKTGKLD-AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFV 783

  Fly   772 EEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCE--F 834
            .:|::..|:|.|..     |.|..|  |:...:::|.:.|:.|||.:|...|.::.:..:.|  |
  Rat   784 GDGEMEELETLWLT-----GICHNE--KNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841

  Fly   835 VWKSR 839
            .||.|
  Rat   842 YWKLR 846

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.