DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grin3a

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	898	Identity:	204/898 - (22%)
Similarity:	359/898 - (39%)	Gaps:	186/898 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AVDRINADRSILPRS---KLVAQIER------ISPF---------DSFHAGKRVCGLLNI-GVAA 95
            ||:.:|....:||.:   ::|..||.      :.||         |.|...:.||..:.: ||:|
Mouse   131 AVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSA 195

  Fly    96 IFG-PQSSHTASHVQSICDNMEIPHL-----------ENRWDYRLRRESCL-------VNLYPHP 141
            :.. |||......:..:...:.||.|           :|....:|..|:.|       |::....
Mouse   196 LLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMN 260

  Fly   142 NTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD----YRPLL 202
            |..:.:.:.....|....|.::.|||.         |.|..:...||. .||.:.|    .:..|
Mouse   261 NWYNFSLLLCQEDWNITDFLLLTENNS---------KFHLESIINITA-NLSSTKDLLSFLQVQL 315

  Fly   203 KQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTV-----NLDEFRYGGTN 262
            :.|:||....::..|....|.::.:.:.|.|:         :..|||.|     |::|.|..|..
Mouse   316 ENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGL---------SPPDLHWVLGDSQNVEELRTEGLP 371

  Fly   263 ITGFRLINEKIVSDVVRQWSIDEKGLLRS--ANLTTVRSETALMYDAVHLFAKALHDLDTSQQID 325
            : |. :.:.|....|...:..|...|:..  |..|.::.|.||:...::.......:|.:.|.
Mouse   372 L-GL-IAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQY-- 432

  Fly   326 IHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQ---GFRTDFMLDIVELTPAG---IRK 384
                             |..::.....:||:..||....   ....:|.:..::..|.|   ..:
Mouse   433 -----------------LSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTR 480

  Fly   385 IGTWNS---TLPDGINFTRTFSQKQQEIEANL--KNKT-LVVTTILSNPYCMRKE---------- 433
            :|:|..   .:..||     :.::.|..:.:.  .||. |.|.|::.:|:...:|
Mouse   481 LGSWQGGRIVMDSGI-----WPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAG 540

  Fly   434 -------------------------SAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSY 473
                                     ..:|:.......||.:||:.::::.:.|::.:.:|.||.|
Mouse   541 QLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKY 605

  Fly   474 GSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLF 538
            |:..  .|.|.|::.:||...|::|:...:|...|.|.:|||:||.:..:.||.|......| :.
Mouse   606 GAWK--NGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IG 667

  Fly   539 SFLSPLSLDVWIYMATAYLGVSVLLFILAKF-TPYEW--PAYTDAHG---EKVESQFTLLN-CMW 596
            :|:.||...:|       ||:.|.|.|.|.| |.|||  |......|   .||.|..:.|| |..
Mouse   668 AFMWPLHWTMW-------LGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYA 725

  Fly   597 FAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAED--LAK 659
            ...|   :......||..:.|.:..:|..|.:..:|:|||||||.:..|::...:....|  |..
Mouse   726 LLFG---RTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHH 787

  Fly   660 QTR-IKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSY-AFLM 722
            .:: .::|.::..|...:.|.|....::.|..:...|.|        :||:.:....... ||:|
Mouse   788 PSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATP--------DGVQYLKNDPEKLDAFIM 844

  Fly   723 ESTSIEYVT--ERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWK 785
            :...::|..  :.:|:|..||.....:.|||..|||||..:.|:.:|.:.:..|.:.:|..||:|
Mouse   845 DKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYK 909

  Fly   786 EKRGGGKCRVETSKSSSAANE---LGLANVGGVFVVLMGGMGVACVIAVCEFV 835
            .        |...|.|.|..|   :|:.:..|:||:|..|.|::.:..:.|.:
Mouse   910 V--------VPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	80/404 (20%)
		ANF_receptor	42..378	CDD:279440	75/379 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	108/418 (26%)
		Lig_chan	547..823	CDD:278489	79/291 (27%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	81/410 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	106/416 (25%)
		Lig_chan	676..942	CDD:278489	79/291 (27%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		1/4 (25%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810