DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and glr-7

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	875	Identity:	218/875 - (24%)
Similarity:	372/875 - (42%)	Gaps:	202/875 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 ASHVQSICDNM--------------------------EIPHLE---NRWDYRLRRESCLVNLYPH 140
            :|.:.|:||.|                          ::|.::   |.|...|......|.....
Worm    22 SSDINSLCDQMVNVSFVISVCRSNDSISLVAELARISQVPTIQVDLNYWSLPLNFNGTSVPTISS 86

  Fly   141 P-------------NTLSKAYVDIVRHWGWKTFTIIYEN---------NDGIVRLQELLKAHGMT 183
            |             |.::..:.|:..   ....|::|:|         .|..    .:|......
Worm    87 PSYTTMVLSTLVFQNVITDIFADLNI---TPNSTVLYDNMYPPDFTAWRDAF----SVLPGIRFV 144

  Fly   184 PFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDL 248
            |...||.::      |..:.|::.::...::|...||.:.....:|........:::|::|.
Worm   145 PMETTVLRM------RAQITQLRMASINSLILVAKTENVERFTLEAADFIEQRVFNTYVLTK--- 200

  Fly   249 HTVNLDEFRYGGTNITGFRLIN-EKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYD------ 306
                         :||.|:..: |......:|.:.:.:...:|..:....|:|..|..|
Worm   201 -------------DITAFKCDSCESAFMFWLRPFPVGKLMEIRDLDDYLFRNEIGLELDYSINGW 252

  Fly   307 -------AVHLFAKALHDLDT-SQQIDIHP-ISCD------------------------GQSTWQ 338
                   .:::...|...:.| :...|:.| .:|.                        |..| :
Worm   253 DSLNVAFYMNVMGYAFETIRTMNATFDVLPTFTCQTGPSEPNITTTVRDIILNDPAHEYGNYT-E 316

  Fly   339 HGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFS 403
            .|.::  :.:.||::    :.|.|......|.:.:         :::|.|:.        ....|
Worm   317 AGLNM--FFQDVEVR----IYKIDRDRDHEDALFN---------KEVGVWSP--------ISKLS 358

  Fly   404 QKQQEIEANLKNKTLV-VTTILSNPYCMRKESAIPLSGNDQ--FEGYAVDLIHEISKSLGFNYKI 465
            .....::.:::|..:. |.|::..|:..|       :|:..  :|||.:|||:.|...:.|.|.|
Worm   359 VMYGTLQVDVRNLNIFRVVTLIQPPFVQR-------TGDPDTPYEGYCIDLINMIQVEVNFTYTI 416

  Fly   466 QLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNL-GVSILYRK 529
            ..|.|||:|:::. .|.|||:|..|:...||:|:|.|::..|||..||||.|:.:| |.:||.:|
Worm   417 YEVEDGSFGTMDD-NGNWNGLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDLVGTTILMKK 480

  Fly   530 PIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVES-QFTLLN 593
            ...: .:||.|:..|...||:.:..|||..|:||:|..:|:||.:....:.:...:|. ||:|..
Worm   481 ADVE-YSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTNNKERYQNDIEKRQFSLKE 544

  Fly   594 CMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLA 658
            |:||.:.||..||....||.:|.|:||..||.|..|:|:||||||||||||.|::.||.|.:|||
Worm   545 CLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSRLEQPISSLDDLA 609

  Fly   659 KQTRIKYGALKGGSTAAFFR---------------------------------DSKIS-TYQRMW 689
            ||.:|:|..:||.::..:||                                 |..:| .:..||
Worm   610 KQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRAKLAVWDYPVSDKFTNMW 674

  Fly   690 SFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATP 754
            .:|:.::..|   :....|:||......:||:.::|.|:|....||.|.|||.....|.|.||..
Worm   675 RYMQESKLPV---NMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCNLQQVGTEFSRKPYAIAVQ 736

  Fly   755 PNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVL 819
            .....:..|:|.||.|..|.:|..||.|||.:...    :|....||..::.:.:.|:||||:|:
Worm   737 SGHILKDKISSAILMLLNERRLETLKEKWWTDNPN----KVSCPDSSDESDGISIQNIGGVFIVI 797

  Fly   820 MGGMGVACVIAVCEFVW---KSRKVAVEER 846
            :.|:.::.|....|:.:   |:||.|.:|:
Worm   798 LAGIALSIVTLAFEYYYYKRKARKAAEKEQ 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	54/382 (14%)
		ANF_receptor	42..378	CDD:279440	52/363 (14%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	145/408 (36%)
		Lig_chan	547..823	CDD:278489	106/310 (34%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	21/146 (14%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	144/405 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810