DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and glr-4

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	881	Identity:	298/881 - (33%)
Similarity:	476/881 - (54%)	Gaps:	98/881 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLQLILNCRKAQSLPDIIKIG-----GLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQI 70
            ||::..|.|    .:..|...||     |.|  |.:|    .|.|:||.|.:.....:.|    .
Worm    14 LLVIFYIAN----SAADDRFHIGTIANRGSF--AYEH----LRYAIDRWNTEHGAHTQIK----F 64

  Fly    71 ERISP--FDSFHAGKRVCGLLNIGVAAIF--GPQSSHTASHVQSICDNMEIPHLENRWDYRLRRE 131
            ..:||  :|:.:. :|:|.::..|:.|:.  ..:|...:..::|:|....||.|..:........
Worm    65 SIVSPIRYDNNYE-ERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQSTSLRDSV 128

  Fly   132 SCLVNLY-PHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAH-----GMTPFPITVR 190
            |..|.|. |.....::|..:.:....|..|.:.|::...:..|..|::..     |.....|.:|
Worm   129 SDFVTLLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTGGRRIHIKIR 193

  Fly   191 QL-SDSGDYRPLLKQIKNS-AEAHIVLDCSTERI-HEVLKQAQQIGMMSDYHSYLVTSLDLHTVN 252
            :| :::.||.|.||.:|.. .:.:|::..:...: :.:|:||:.:.|.....||:.|:.||..
Worm   194 RLPNNTDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFSYVFTNTDLSL-- 256

  Fly   253 LDEF---RYGGT---NITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLF 311
            |::|   .||.:   ||||.:|:.                      |...::::.||..:||::.
Worm   257 LEDFLNNMYGASFHCNITGLQLVK----------------------NDPMMKTQLALTSEAVYVV 299

  Fly   312 AKALHDLDTSQQIDIHP----ISCDGQSTWQHGFSLINYMKIVEMKG-LTNVIKFDHQGFRTDFM 371
            ..:::.:   :::...|    |.||....|..|..:...::.::::. ||..::|...|.|.|.|
Worm   300 GMSIYRM---RELGHAPRQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQLTGDVQFKSNGERDDIM 361

  Fly   372 LDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQ-EIE---ANLKNKTLVVTTILSNPYCMRK 432
            ...|....:...|:|.|:.  ..|.||...::.:.: :|:   .:|:...|.|...|..|:.::
Worm   362 YHGVGRINSQFVKLGNWSE--KRGWNFDSRYANRWEFDIDPDSEDLEGLHLRVVVYLEEPFVIK- 423

  Fly   433 ESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADL 497
                  :|.:|:||:.:||::|:::.|.|||.|..|.||:|| :...:|.|||:|..|....|||
Worm   424 ------TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYG-IEDESGRWNGIIGALQRHEADL 481

  Fly   498 AIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPP--NLFSFLSPLSLDVWIYMATAYLGVS 560
            :::.:|||:.|.:.||||.|||:||:|||..:..::..  :|::||.||||.|||.:..:|..||
Worm   482 SLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSLTVWISLLISYCIVS 546

  Fly   561 VLLFILAKFTPYEW---PAYTDAHGEKV---ESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMV 619
            ..:.|||||:||||   ....:...|.:   ::|||:||..||.:|||||||.|.:|:|.:||::
Worm   547 YSMHILAKFSPYEWYNLERIDERDFENIKNQKNQFTVLNSFWFTMGSLMQQGSDVIPRAAATRLI 611

  Fly   620 AGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKIST 684
            |.:||.||.|:||||||.||||||||||.:||||.:|||.|.:|:||.||.|||..|||:|||..
Worm   612 AVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRYGVLKSGSTMDFFRESKIPM 676

  Fly   685 YQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSY 749
            |:||||.|||:.|.||..|:.||:.||.  .|.||::|||:.:||..||:|||..:||:||:|.|
Worm   677 YERMWSVMESSSPGVFVNSSREGIARVK--SGGYAYMMESSMLEYYLERDCELQSIGGLLDSKGY 739

  Fly   750 GIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGG 814
            |||.|..||.|..::..:|:|||...|..||.|||:::|.|..|....|:.::.:..   .|:.|
Worm   740 GIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEKATNSKP---QNIFG 801

  Fly   815 VFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLSAI 850
            :|.||:.|:.||.::|..|:..:||..|...:|:.:
Worm   802 IFYVLLTGLIVAFLLACGEYCIESRHEAFRLKLTIV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	87/394 (22%)
		ANF_receptor	42..378	CDD:279440	78/359 (22%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	183/377 (49%)
		Lig_chan	547..823	CDD:278489	140/281 (50%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	87/394 (22%)
		ANF_receptor	45..365	CDD:279440	76/351 (22%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	183/374 (49%)
		Lig_chan	533..810	CDD:278489	140/281 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40717
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960