DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and glr-3

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	773	Identity:	284/773 - (36%)
Similarity:	429/773 - (55%)	Gaps:	65/773 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VCGLLNIGVAAIFGPQ--SSH--TASHVQSICDNMEIP----HLENRWDYRLRRESCLVNLYPHP 141
            ||..|.:|.:||..|:  ..|  .|:.||||.||..:|    ||...     .|.|  .:|:||.
Worm    75 VCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVSLHLSPP-----TRPS--THLHPHL 132

  Fly   142 NTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTP--FPITVRQLSDSGDYRPLLKQ 204
            |..|.|....::...||...:::|..|.::.:.:::.|....|  |...:.:|....||...||.
Worm   133 NAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMITAGHFDPDSFSSQLVRLKHGDDYGNELKH 197

  Fly   205 IKNSAEAH-IVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFR-YGGTNITGFR 267
            |||..:.: ||::...::....|:||..:.|....:.|:|..:||.||::|..| ....|||.|.
Worm   198 IKNKLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDLVTVDIDSIRGIEDCNITSFG 262

  Fly   268 L--INEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPIS 330
            :  :|.:.:.| :|| .|..|..:|... ..|...|::..|.:.|..:::..:    ||...| .
Worm   263 VHDVNSEYIED-IRQ-EIVHKSSIRLPK-KGVPYTTSIWIDTLRLLIRSMKSI----QIWDEP-R 319

  Fly   331 CDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDG 395
            |.  |:|:.|..:........:.|::..:.:...|.|:::.|.:...| ...:|...|:|.
Worm   320 CG--SSWKSGSDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYRRT-LSFQKFAEWSSR---- 377

  Fly   396 INFTRTFSQKQQEIEAN------LKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHE 454
               ||..:..:..:.||      |:.|.|.::..|..|:.|       ::.|..:|||.:||:|:
Worm   378 ---TRRIASSEAVVIANSSEKLTLEGKHLKISVYLEAPFVM-------ITSNGSYEGYCIDLLHK 432

  Fly   455 ISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFM 519
            |:..|.|.|.||.|.|.:||| .:..|:|:||:.||....||||:|.|||::.|.:.:|||.|:|
Worm   433 IANILKFTYTIQKVRDNAYGS-KESNGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYM 496

  Fly   520 NLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGE- 583
            :||:|||::||..:..:.|.|:.|||..|||....:|..|||.::|:||.:|||.....:.:|:
Worm   497 HLGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQY 561

  Fly   584 -KVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERM 647
             .|::||:|.|..||.:.||||||.:..|:|.|||::.||||||.||:||||||||||.||..||
Worm   562 KPVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRM 626

  Fly   648 DSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVA 712
            ::|||:|:|||.||:||||.|..|||.:||.:|||.||:|||..|.|: |.:|..|:.||:.||.
Worm   627 ETPIENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMWQLMSSS-PGLFVQSSKEGIARVK 690

  Fly   713 KGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLH 777
              ...||:||||:.:||..||:|||.|:||::|.|.|||..|..||||..|::.||:|||:.:|.
Worm   691 --SSDYAYLMESSMLEYAVERDCELMQIGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELT 753

  Fly   778 ILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFV 835
            .||.||||:|  ...|.....|......     ::||:|::|:.|:.:..|:.:.|.:
Worm   754 ELKEKWWKDK--SVVCEQPKRKDQDDGE-----SIGGIFIILVVGLVLTAVLVIFELI 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	85/325 (26%)
		ANF_receptor	42..378	CDD:279440	81/306 (26%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	182/371 (49%)
		Lig_chan	547..823	CDD:278489	136/277 (49%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	87/334 (26%)
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	182/370 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40717
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800