DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grin3b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	194/837 - (23%)
Similarity:	318/837 - (37%)	Gaps:	214/837 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 AIFGPQSSHT----ASHVQSICDNMEIPHLENRWD------YRLRRESCLVNLYP-HPNTLSKAY 148
            |:..|...|.    ||.:::|.|.:......:.|:      .|:|....||.|:. |.:...|..
  Rat   138 ALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPKFV 202

  Fly   149 VDIVRHWGWKTFTIIYENNDGIVRLQELLKA--HGMTPFPITVRQLSDSGDYRPLLKQIKNSAEA 211
            :|:.|         :...||.:.....||.|  .|.||.|                        |
  Rat   203 LDLSR---------LDSRNDSLRAGLALLGALEGGGTPVP------------------------A 234

  Fly   212 HIVLDCSTERIHEVLKQAQQ-----IGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINE 271
            .::|.|||.|.||||:.|..     :|......:...|.|....:.|.|
  Rat   235 AVLLGCSTARAHEVLEAAPPGPQWLLGTPLPAEALPTTGLPPGVLALGE---------------- 283

  Fly   272 KIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHP-------- 328
                                   |...|..|:::|.|.|.|:||     |....:||
  Rat   284 -----------------------TEQHSLEAVVHDMVELVAQAL-----SSMALVHPERALLPAV 320

  Fly   329 ISCDGQSTW---QHGFSLINYMKIVEMKGLTNVI------------KFDHQGFRTDFMLDIVELT 378
            ::||...|.   ..|.:|..::.....:|.|..:            .|.....|.|
  Rat   321 VNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRD--------- 376

  Fly   379 PAGI---RKIGTWNSTLPD---GINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKES--- 434
            |.|.   ..:|:|.....|   |....|..|....:....|:     |.|::.:|:...:||
  Rat   377 PLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLR-----VVTLVEHPFVFTRESDED 436

  Fly   435 ------------------------------AIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVP 469
                                          ::|.:......||.:||:..:::.|.|::::.:|.
  Rat   437 GQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVG 501

  Fly   470 DGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQP 534
            ||.||:|.  .|.|.|::.:||..||.:|:...:|...|.|.||||:||.:..:.|:.|......
  Rat   502 DGKYGALR--DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTAS 564

  Fly   535 PNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKF-TPYEW--PAYTDAHGEK---VESQFTLLN 593
            | :.:|:.||...:|:       ||...|.:.|.| |.|||  |......|..   |.|..:.||
  Rat   565 P-IGAFMWPLHWSMWV-------GVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALN 621

  Fly   594 -CMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAED- 656
             |.....|..:...   .||..:.|.:..:|..|.|:::|||||||||.:..::....:....|
  Rat   622 LCYAILFGRTVSSK---TPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683

  Fly   657 -LAKQTR-IKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYA 719
             |...:: .::|.:...|..|:.:    :::..|.:.|.  |.|..|..:|..:......|.: |
  Rat   684 KLHHPSQGFRFGTVWESSAEAYIK----ASFPEMHAHMR--RHSAPTTPHGVAMLTSDPPKLN-A 741

  Fly   720 FLMESTSIEYVT--ERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTK 782
            |:|:.:.::|..  :.:|:|..||.....:.|||..|.|||..:.::..|.:.:..|.:.:|..|
  Rat   742 FIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK 806

  Fly   783 WWKEKRGGGKCRVETSKSSSAANE---LGLANVGGVFVVLMGGMGVACVIAVCEFVW 836
            |:|        .|...|...|..|   :|:.:..|:||:|..|:|.|.:.::.|.|:
  Rat   807 WYK--------MVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVF 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	70/348 (20%)
		ANF_receptor	42..378	CDD:279440	64/323 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	106/414 (26%)
		Lig_chan	547..823	CDD:278489	75/290 (26%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	70/352 (20%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	106/418 (25%)
		Lig_chan	576..842	CDD:278489	75/290 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910