DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grin3b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	913	Identity:	208/913 - (22%)
Similarity:	354/913 - (38%)	Gaps:	235/913 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SILP-----RSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIP 118
            ::||     |::::|.:...||        |:...|::.:.|:..| :...||..:.:|..:..|
Mouse   123 ALLPRAPAARARVLAALATPSP--------RLPHNLSLELVAVASP-TRDPASLARGLCQVLAPP 178

  Fly   119 HL-------ENRWDYR----------------LRRESCLVNLYPHP-----------NTLSKAYV 149
            .:       |.|.:.|                ||||.......|.|           .|:....|
Mouse   179 GVVASITFPEARPELRLLQFLAAATETPVLSVLRREVRAPLGAPTPFHLQLDWASPLETILDVLV 243

  Fly   150 DIVRHWGWKTFTII---YENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD-----YRPLLKQIK 206
            .:||...|:...::   ..:..|:|.|. ..:|.....|.:.:.|| |||:     ...||..::
Mouse   244 SLVRAHAWEDIALVLCRVRDPSGLVTLW-TSRASQAPKFVLDLSQL-DSGNDSLRATLALLGTLE 306

  Fly   207 NS---AEAHIVLDCSTERIHEVLKQAQQ-----IGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNI 263
            ..   ..|.::|.|||...||||:.|..     :|......:...|.|....:.|.|
Mouse   307 GGGTPVSAAVLLGCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPPGVLVLGE-------- 363

  Fly   264 TGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHP 328
            ||              |.|::                 |.::|.|.|.|:||     |....:||
Mouse   364 TG--------------QPSLE-----------------AAVHDMVELVARAL-----SSMALMHP 392

  Fly   329 --------ISCD------GQSTWQHGFSLINYMKIVEMKGLTNVI------------KFDHQGFR 367
                    ::|:      .:||.:   :|..::.....:|.|..:            .|.....|
Mouse   393 ERALLPAAVNCEDLKTGGSESTAR---TLARFLSNTSFQGRTGAVWVAGSSQVHVSRHFKVWSLR 454

  Fly   368 TDFMLDIVELTPAGI---RKIGTWNSTLPD---GINFTRTFSQKQQEIEANLKNKTLVVTTILSN 426
            .|         |.|.   ..:|:|.....|   |....|..|....:....|:     |.|::.:
Mouse   455 RD---------PLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLR-----VVTLVEH 505

  Fly   427 PYCMRKES---------------------------------AIPLSGNDQFEGYAVDLIHEISKS 458
            |:...:||                                 ::|.:......||.:||:..:::.
Mouse   506 PFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAED 570

  Fly   459 LGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGV 523
            |.|::::.:|.||.||:|.  .|.|.|::.:||..||.:|:...:|...|.|.||||:||.:..:
Mouse   571 LAFDFELYIVGDGKYGALR--DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSL 633

  Fly   524 SILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKF-TPYEW--PAYTDAHGEK- 584
            .|:.|......| :.:|:.||...:|:       ||...|.:.|.| |.|||  |......|..
Mouse   634 GIMVRTRDTASP-IGAFMWPLHWSMWV-------GVFAALHLTALFLTLYEWRSPYGLTPRGRNR 690

  Fly   585 --VESQFTLLN-CMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVER 646
              |.|..:.|| |.....|..:...   .||..:.|.:..:|..|.|:::|||||||||.:..::
Mouse   691 GTVFSYSSALNLCYAILFGRTVSSK---TPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDK 752

  Fly   647 MDSPIESAED--LAKQTR-IKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGV 708
            ....:....|  |...:: .::|.:...|..|:.:    :::..|.:.|.  |.|..|..:|..:
Mouse   753 TFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIK----ASFPEMHAHMR--RHSAPTTPHGVAM 811

  Fly   709 ERVAKGKGSYAFLMESTSIEYVT--ERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQ 771
            ......|.: ||:|:.:.::|..  :.:|:|..||.....:.|||..|.|||..:.::..|.:.:
Mouse   812 LTSDPPKLN-AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYK 875

  Fly   772 EEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANE---LGLANVGGVFVVLMGGMGVACVIAVCE 833
            ..|.:.:|..||:|        .|...|...|..|   :|:.::.|:||:|..|:|.|.:.::.|
Mouse   876 SSGFIDLLHDKWYK--------MVPCGKRVFAVTETLQMGVYHLSGLFVLLCLGLGSALLTSLGE 932

  Fly   834 FVW 836
            .|:
Mouse   933 HVF 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	84/424 (20%)
		ANF_receptor	42..378	CDD:279440	78/399 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	106/414 (26%)
		Lig_chan	547..823	CDD:278489	75/290 (26%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	80/406 (20%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	106/418 (25%)
		Lig_chan	656..922	CDD:365843	75/290 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810