DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and gria3a

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	823	Identity:	326/823 - (39%)
Similarity:	492/823 - (59%)	Gaps:	51/823 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRS-KLV 67
            :.||:||.|:||      .....|:.|.|||||..:...:..|||.||...|.:::|..:. .|.
Zfish     7 ASVLLLPWLVLQ------TQAGFPNQINIGGLFMRSTVQEHSAFRFAVQLYNTNQNITEKPFHLN 65

  Fly    68 AQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNME----IPHLENRWDYRL 128
            ..::.:...:||......|...:.||.||||.....:.:.:.|.|..:.    .|......|.:.
Zfish    66 YNVDNLESSNSFSVTHAFCSQFSRGVYAIFGFYDRRSMNTLTSFCGALHTSFITPSFPTDTDVQF 130

  Fly   129 RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS 193
                 ::.:.|   :|..|.:.::.|:.|:.|..:|:.:.|...||.::::..|..:.:|.|.:.
Zfish   131 -----VLQMRP---SLRGALLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTARSVG 187

  Fly   194 ---DSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDE 255
               |..:||.:::::....|...::||..|||:.:|:|....|..|..:.|::.:|....::||:
Zfish   188 NIVDPLEYRRIIEEMDRRQEKRFLIDCEVERINSILEQVVIAGKNSRGYHYILANLGFTNMSLDK 252

  Fly   256 FRYGGTNITGFRLIN--EKIVSDVVRQWS-IDEKGLLRSANLTTVRSETALMYDAVHLFAKALHD 317
            ...||.|||||::||  ..||...:::|. :||:....|.: :.::..:||.:||:.:.|:|...
Zfish   253 VFSGGANITGFQIINPDSPIVQQFLQRWERLDEREFPESRS-SPLKYTSALTHDAILVIAEAFRY 316

  Fly   318 LDTSQQIDIHPISCDGQS------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVE 376
            | ..|::||......|..      .|..|..:...:|:|:::|:|..|:||..|.|:::.:|:.|
Zfish   317 L-RRQRVDISRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRSNYTVDVYE 380

  Fly   377 LTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGN 441
            :.|.|.||||.||    :...|.....|:.....::::|:|:|||||:..||.|.|.:.:.|.||
Zfish   381 MKPGGARKIGYWN----EFEKFVYIVEQQVTNESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGN 441

  Fly   442 DQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITF 506
            |::|||.|||..||:|.:|..||:.:|.||.||:.:..|..||||:.||:..|||:|:|.||||.
Zfish   442 DRYEGYCVDLASEIAKHVGIKYKLSIVADGKYGARDPETKTWNGMVGELVYGRADIAVAPLTITL 506

  Fly   507 EREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTP 571
            .||:.:||:.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:|
Zfish   507 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 571

  Fly   572 YEWPAYTDAHGEKVESQ--------FTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTL 628
            |||  :.|.:.|..:.|        |.:.|.:||::|:.||||||..|::||.|:|.|:||||||
Zfish   572 YEW--HLDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTL 634

  Fly   629 IMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFME 693
            |:|||||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::|||:|:
Zfish   635 IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMK 699

  Fly   694 SARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNS 757
            ||.||||..:..:||.||.|.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|
Zfish   700 SAEPSVFVKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGS 764

  Fly   758 PYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKS 800
            ..||.:|..:|||.|:|.|..||.|||.:|   |:|..:.|.|
Zfish   765 ALRTPVNLAVLKLSEQGILDKLKNKWWYDK---GECGTKDSGS 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	103/382 (27%)
		ANF_receptor	42..378	CDD:279440	90/352 (26%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	206/378 (54%)
		Lig_chan	547..823	CDD:278489	143/263 (54%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	103/384 (27%)
		ANF_receptor	39..382	CDD:279440	90/352 (26%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	209/386 (54%)
		Lig_chan	547..810	CDD:278489	143/263 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820