DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and gria2b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	862	Identity:	332/862 - (38%)
Similarity:	508/862 - (58%)	Gaps:	57/862 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERI 73
            |.:.|:.|:|......| |. ::|||||....|.:..|||..:.:...     ...:|...|:.:
Zfish     7 LSICLIALLLGMTTGGS-PS-VQIGGLFPRGADQEYSAFRIGMVQFGT-----AEFRLTPHIDNL 64

  Fly    74 SPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLY 138
            ...:||......|...:.||.||||.....:.:.:.|.|..:.:..:...:... ..:..::.:.
Zfish    65 EVANSFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPLD-GNQQFIIQMR 128

  Fly   139 PHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD------ 197
            |   .:....:.::.::.|..|..:|:::.|:..||.:|.......:.:|...:.:..|
Zfish   129 P---DIKGPLLSLIEYYKWDKFAYLYDSDRGLTTLQVVLDTAAEKKWQVTAINVGNMKDERKDEA 190

  Fly   198 YRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGT 261
            ||.|.:.::|..|..::|||..:::.::::|...||. :..|| |::.:|.....:|.:.:|||.
Zfish   191 YRSLFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYH-YIIANLGFVDGDLSKIQYGGA 254

  Fly   262 NITGFRLI--NEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQI 324
            |::||:::  ::.:||...::|...|:.....|: :.:|..:||.||||.:..:|...|. .|:|
Zfish   255 NVSGFQIVDFDDPLVSKFDQRWEALEEKEYPGAD-SKIRYTSALTYDAVQVMTEAFRYLH-KQRI 317

  Fly   325 DIHPISCDGQS------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIR 383
            ||...:.:|..      .|..|..:...:|.|.:.|||..|:||..|.|.::.::::||...|..
Zfish   318 DISRRANNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGKRVNYTVNVMELKSNGAV 382

  Fly   384 KIGTWNSTLPDGINFTRTFSQKQQEIEAN----LKNKTLVVTTILSNPYCMRKESAIPLSGNDQF 444
            |||.||..  |.:..|::      ::..|    |:|||::|||||..||.|.|::|.....|:::
Zfish   383 KIGYWNEV--DKMVVTKS------DLFPNDTMGLENKTVIVTTILEAPYVMLKKNADLFMDNERY 439

  Fly   445 EGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFERE 509
            |||.|||..||:|..||.|::::|.||.||:.:..|..||||:.||:..:||:|:|.||||..||
Zfish   440 EGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITLVRE 504

  Fly   510 QAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW 574
            :.:||:.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||
Zfish   505 EVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW 569

  Fly   575 --PAYTDAHGEKVES--QFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYT 635
              ..|.|...:..||  :|.:.|.:||::|:.|:||||..|::||.|:|.|:|||||||:|||||
Zfish   570 HTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYT 634

  Fly   636 ANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVF 700
            ||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.:.:||::|:.|.||||
Zfish   635 ANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWTYMKGAEPSVF 699

  Fly   701 TASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAIN 764
            ..:..|||.||.|.||.||:|:|||..||:.:|. |:..:|||.||:|.||||||..|..|.|:|
Zfish   700 VKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 764

  Fly   765 SVILKLQEEGKLHILKTKWWKEK----RGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGV 825
            ..:|||.|:|.|..||.|||.:|    .|||..:.:||       .|.|:||.|||.:|:||:|:
Zfish   765 LAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTS-------ALSLSNVAGVFYILVGGLGL 822

  Fly   826 ACVIAVCEFVWKSRKVA 842
            |.::|:.||.:|||..|
Zfish   823 AMLVALVEFCYKSRAEA 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	94/380 (25%)
		ANF_receptor	42..378	CDD:279440	80/350 (23%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	203/374 (54%)
		Lig_chan	547..823	CDD:278489	152/284 (54%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	94/381 (25%)
		ANF_receptor	55..377	CDD:279440	77/328 (23%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	205/379 (54%)
		Lig_chan	542..820	CDD:278489	152/284 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850