Protein Alignment KaiR1D and Grik5

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_030098003.1
• Gene: Grik5 / 14809
• MGIID: 95818
• Length: 1003
• Species: Mus musculus
• Alignment Length: 890
• Identity: 356/890 - (40%)
• Similarity: 526/890 - (59%)
• Gaps: 83/890 - (9%)

  Fly    12 LLLQLIL-----NCRKAQSLPDIIKIGGLFHPADDH------QELAFRQAVDRINADRSILPRSK 65
            |||.||:     :|:...||    ::..:.   ||.      :.||...|.::||....:..:::
Mouse     5 LLLLLIVAFANPSCQVLSSL----RMAAIL---DDQTVCGRGERLALALAREQINGIIEVPAKAR 62

  Fly    66 LVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSS-HTASHVQSICDNMEIPHLE------NR 123
            :...|..:.....:.....:|.:|..||.::.||.|| .:||.|..||...||||::      .|
Mouse    63 VEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPR 127

  Fly   124 WDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT 188
            ..| ||..|  |:|||....:|.|...|::.:.:.:.::|....:.::||:||::...::...::
Mouse   128 LQY-LRFAS--VSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLS 189

  Fly   189 VRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLK-----------------------QAQ 230
            ||.|.||.|..||||:|::...:.|::|.:....|.||:                       ||.
Mouse   190 VRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQAS 254

  Fly   231 QIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIVSDVVRQWSIDEKGLLRSAN 293
            ::||.|.::.|::|::|...::||......:||.||.:.|  .....:.||..::..:....::.
Mouse   255 ELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEAST 319

  Fly   294 LTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNV 358
            ........|||:||||:...|:.:|:.||:|.:.|::|...:.|.||.||:||:::||..|||..
Mouse   320 YPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGR 384

  Fly   359 IKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLK----NKTLV 419
            ::|:.:|.||::.|.|:|.:..|.|:||.|.|        .||.:.....::.||.    |||||
Mouse   385 VEFNSKGQRTNYTLRILEKSRQGHREIGVWYS--------NRTLAMNATTLDINLSQTLANKTLV 441

  Fly   420 VTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWN 484
            |||||.|||.||:.:...||||::|||:.||::.|:::.|.|.|:::||.||.||: .:..|.|.
Mouse   442 VTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGA-PEPNGSWT 505

  Fly   485 GMIRELL-EQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDV 548
            ||:.||: .|:||||:|..|||.|||:.:||:.|||.||:|||||..:.:.|..||||.|.|..|
Mouse   506 GMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAV 570

  Fly   549 WIYMATAYLGVSVLLFILAKFTPYEWPAYTD-----AHGEKVESQFTLLNCMWFAIGSLMQQGCD 608
            |::|..|||.||.:||:.|:.:||||  |..     |....:|:|:||.|.:||.:|..||||.:
Mouse   571 WLFMLLAYLAVSCVLFLAARLSPYEW--YNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSE 633

  Fly   609 FLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGST 673
            .:|:|||||.|:|:||.||||:||||||||||||||:||:.|:|||:|||.||.|:||.:..|||
Mouse   634 IMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST 698

  Fly   674 AAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELT 738
            ..||::|:..||||||::|:|.:||||..|..||:.||...:  ||||:|||..||....||.||
Mouse   699 MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLT 761

  Fly   739 QVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSA 803
            |:||:||||.|||..|..||:|..|...||:|||..:|.|||.|||:    ||:|..|   ....
Mouse   762 QIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE----GGRCPKE---EDHR 819

  Fly   804 ANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLS 848
            |..||:.|:||:||||:.|:.:|..:||.||:|.:|:.|..|.:|
Mouse   820 AKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVS 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	114/406 (28%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	204/375 (54%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	118/418 (28%)
		Periplasmic_Binding_Protein_Type_2	437..808	CDD:473866	204/375 (54%)