Protein Alignment KaiR1D and Grik3

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 852
• Identity: 399/852 - (46%)
• Similarity: 577/852 - (67%)
• Gaps: 49/852 - (5%)

  Fly    23 AQSLPDIIKIGGLFHPAD-------DHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFH 80
            ::.:|.:|:|||:|..||       :.:|.|||.:.:.||.:|::||.:.|...|:||...|||.
Mouse    29 SRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFE 93

  Fly    81 AGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNT 143
            |.|:.|..|.:||.|||||......:.|||||:.:|:||::.||.:..  .:::..|||||...:
Mouse    94 ATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYAS 158

  Fly   144 LSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKN 207
            ||.|.:|:|:...|::.|::|:::.|::|||||:.|.......:.:|||. ||.|.|||||::|.
Mouse   159 LSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKR 223

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN-- 270
            ..|..|:.|||.....::||||..:|||::|:.::.|:|||:.::|:.:||.|.|:||||::|
Mouse   224 GREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVD 288

  Fly   271 EKIVSDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIH 327
            ...||.:|.:|:::        |.|||....:|    :.||:|||||:.:..   ...:.|:.::
Mouse   289 NPHVSAIVEKWAMERLQAAPRAESGLLDGVMMT----DAALLYDAVHIVSVC---YQRAPQMTVN 346

  Fly   328 PISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGIRKIGTWNST 391
            .:.|.....|:.|...:|::|..:.:|||..|.|:. .|.||||.|||:.|...|:.|:|.|:..
Mouse   347 SLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPA 411

  Fly   392 LPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEIS 456
              ||:|.|.....:...:..:|.|::|:|||:|..|:.|.::|...|.|||:||||.:||:.|::
Mouse   412 --DGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELA 474

  Fly   457 KSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNL 521
            ..|||:|:|:||.||.||:.:. .|:||||::||::.:||||:|.||||..||:|:||:.|||.|
Mouse   475 HILGFSYEIRLVEDGKYGAQDD-KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTL 538

  Fly   522 GVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAH----- 581
            |||||||||....|::||||:|||.|:|:|:..||||||.:||::|:|:||||   .|||
Mouse   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEW---YDAHPCNPG 600

  Fly   582 GEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVER 646
            .|.||:.|||||..||.:|||||||.:.:|||||||::.|||||||||:||||||||||||||||
Mouse   601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVER 665

  Fly   647 MDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERV 711
            |:|||:||:||||||:|:|||:|.|:|..||:.|||||:::||:|| |::||....:|.||::|.
Mouse   666 MESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQRT 729

  Fly   712 AKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776
            .  ...||.|||||:|||:|:|||.|||:||::|:|.|||.||..||||..|...||:||||.||
Mouse   730 L--TADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV 841
            ||:|.|||   ||.| |..|.:|.:||   ||:..:||:|:||..|:.::.::||.||::|.||.
Mouse   793 HIMKEKWW---RGSG-CPEEENKEASA---LGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKT 850

  Fly   842 AVEERLS 848
            |..|:.|
Mouse   851 AEREQRS 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	145/389 (37%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	223/374 (60%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	145/388 (37%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	224/377 (59%)