Protein Alignment KaiR1D and Grik2

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 889
• Identity: 410/889 - (46%)
• Similarity: 595/889 - (66%)
• Gaps: 76/889 - (8%)

  Fly    23 AQSLPDIIKIGGLFHPADD----HQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGK 83
            :|....:::.||:|...:.    .:|||||.||:.||.:|::||.:.|....::|:.:|||.|.|
Mouse    29 SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASK 93

  Fly    84 RVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNTLSK 146
            :.|..|::||||||||..|.:|:.|||||:.:.:||::.||.:::  .::|..|:|||..::||:
Mouse    94 KACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSR 158

  Fly   147 AYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL-SDSGDYRPLLKQIKNSAE 210
            |.:|:|:.:.|||.|::|:::.|::|||||:||.......:.:||| :|:.|.:||||::|...|
Mouse   159 AILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKE 223

  Fly   211 AHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEK--I 273
            .|::.|||.|....:||||..:|||::|:.|:.|:|||..::::.:||.|.|:||||::|.:  .
Mouse   224 FHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQ 288

  Fly   274 VSDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPIS 330
            ||.::.:||::        :.||| ...:||   :.||||||||:.:.|:...   .|:.:..:.
Mouse   289 VSSIIEKWSMERLQAPPKPDSGLL-DGFMTT---DAALMYDAVHVVSVAVQQF---PQMTVSSLQ 346

  Fly   331 CDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGIRKIGTWNSTLPD 394
            |:....|:.|...::.:|....:|||..|.|:. .|.||||.||::.|...|:.|||||:.:  .
Mouse   347 CNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPS--S 409

  Fly   395 GINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSL 459
            |:|.|.:...|...|..:|.|::|:|||||..||.:.|:|..||.|||:||||.:||:.|:|..|
Mouse   410 GLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTIL 474

  Fly   460 GFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVS 524
            ||.|:|:||.||.||:.:.:.|:||||:|||::.:||||:|.|.||:.||:.:||:.|||.||:|
Mouse   475 GFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGIS 539

  Fly   525 ILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAK--------------------- 568
            ||||||....|.:||||:|||.|:|:|:..||||||.:||::|:
Mouse   540 ILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCSHYHHSQRC 604

  Fly   569 --------------FTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTR 617
                          |:||||  |...:...:.||:.|||||..||.:|:|||||.:.:|||||||
Mouse   605 LCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTR 669

  Fly   618 MVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKI 682
            :|.|||||||||:|||||||||||||||||:|||:||:||||||:|:|||::.|:|..||:.|||
Mouse   670 IVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI 734

  Fly   683 STYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTK 747
            |||.:||:||.|.|.||...||.||::||.  ...||||||||:||:||:|||.|||:||::|:|
Mouse   735 STYDKMWAFMSSRRQSVLVKSNEEGIQRVL--TSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSK 797

  Fly   748 SYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANV 812
            .||:.||..||||..|...||:||||||||::|.|||   ||.| |..|.||.:||   ||:.|:
Mouse   798 GYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEEESKEASA---LGVQNI 855

  Fly   813 GGVFVVLMGGMGVACVIAVCEFVWKSRKVA-VEER--LSAILNE 853
            ||:|:||..|:.::..:||.||::||:|.| :|:|  .||::.|
Mouse   856 GGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEE 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	148/386 (38%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	225/406 (55%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	148/385 (38%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:473866	226/409 (55%)