Protein Alignment KaiR1D and Grik1

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 886
• Identity: 423/886 - (47%)
• Similarity: 582/886 - (65%)
• Gaps: 69/886 - (7%)

  Fly     1 MRSSGVLVLP-----------LLLLQLILNCRKAQSLPDIIKIGGLFHPADDH----QELAFRQA 50
            |....||:.|           |..|..||    .|:.|.:::|||:|...::.    :||||:.|
Mouse     1 MERGTVLIQPGLWTRDTSWTLLYFLCYIL----PQTSPQVLRIGGIFETVENEPVNVEELAFKFA 61

  Fly    51 VDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNM 115
            |..||.:|:::|.:.|...|:||:.||||.|.:|.|..|.:||||:|||..|.:.|.|||||:.:
Mouse    62 VTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNAL 126

  Fly   116 EIPHLENRWDYRL--RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLK 178
            |:||::.||.:..  .|:...:||||....:|:|.:|:|.::.|||.|::||::.|::|||||:|
Mouse   127 EVPHIQTRWKHPSVDNRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIK 191

  Fly   179 AHGMTPFPITVRQL-SDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYL 242
            |.......|.:||| |.:.|.:||||::|...|.:::.|||.|...|:|||...:|||::|:.|.
Mouse   192 APSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYF 256

  Fly   243 VTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIVSDVVRQWSID--------EKGLLRSANLTTV 297
            .|:|||..::|:.:||.|.|:|||||:|  ...||.::.:||::        |.|||... :||
Mouse   257 FTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGV-MTT- 319

  Fly   298 RSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFD 362
              |.|||||||::.|.|.|   .:.|:.:..:.|.....|:.|...:|.:|.....|||..|.|:
Mouse   320 --EAALMYDAVYMVAIASH---RASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFN 379

  Fly   363 H-QGFRTDFMLDIVELTPAGI---------------RKIGTWNSTLPDGINFTRTFSQKQQEIEA 411
            . .|.|.||.|||:.|...|.               :|||.|||.  .|:|.|.....:...|..
Mouse   380 KTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSN--SGLNMTDGNRDRSNNITD 442

  Fly   412 NLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSL 476
            :|.|:||:|||||..||.|.::|..||.|||:||||.:||:.|:|..|||.|.::|||||.||:.
Mouse   443 SLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQ 507

  Fly   477 NKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFL 541
            |. .||||||::||::.|||||:|.||||:.||:.:||:.|||.||:|||||||....|.:||||
Mouse   508 ND-KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFL 571

  Fly   542 SPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQ 604
            :|||.|:|:|:..|.||||.:||::|:||||||  |...:...:.||:.|||||..||.:|:|||
Mouse   572 NPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQ 636

  Fly   605 QGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALK 669
            ||.:.:|||||||:|.|||||||||:|||||||||||||||||:|||:||:||||||:|:|||::
Mouse   637 QGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVR 701

  Fly   670 GGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN 734
            .|||..||:.||||||::||:||.|.:.|....::.||::||.  ...||.|||||||||||:||
Mouse   702 DGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVL--TTDYALLMESTSIEYVTQRN 764

  Fly   735 CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSK 799
            |.|||:||::|:|.||:.||..||||..|...||:||||||||::|.|||   ||.| |..|.||
Mouse   765 CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEEDSK 825

  Fly   800 SSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
            .:||   ||:.|:||:|:||..|:.::..:|:.||::||||
Mouse   826 EASA---LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRK 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	157/401 (39%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	227/371 (61%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	157/401 (39%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	228/374 (61%)