DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and Grik1

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	886	Identity:	423/886 - (47%)
Similarity:	582/886 - (65%)	Gaps:	69/886 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSSGVLVLP-----------LLLLQLILNCRKAQSLPDIIKIGGLFHPADDH----QELAFRQA 50
            |....||:.|           |..|..||    .|:.|.:::|||:|...::.    :||||:.|
Mouse     1 MERGTVLIQPGLWTRDTSWTLLYFLCYIL----PQTSPQVLRIGGIFETVENEPVNVEELAFKFA 61

  Fly    51 VDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNM 115
            |..||.:|:::|.:.|...|:||:.||||.|.:|.|..|.:||||:|||..|.:.|.|||||:.:
Mouse    62 VTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNAL 126

  Fly   116 EIPHLENRWDYRL--RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLK 178
            |:||::.||.:..  .|:...:||||....:|:|.:|:|.::.|||.|::||::.|::|||||:|
Mouse   127 EVPHIQTRWKHPSVDNRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIK 191

  Fly   179 AHGMTPFPITVRQL-SDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYL 242
            |.......|.:||| |.:.|.:||||::|...|.:::.|||.|...|:|||...:|||::|:.|.
Mouse   192 APSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYF 256

  Fly   243 VTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIVSDVVRQWSID--------EKGLLRSANLTTV 297
            .|:|||..::|:.:||.|.|:|||||:|  ...||.::.:||::        |.|||... :||
Mouse   257 FTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGV-MTT- 319

  Fly   298 RSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFD 362
              |.|||||||::.|.|.|   .:.|:.:..:.|.....|:.|...:|.:|.....|||..|.|:
Mouse   320 --EAALMYDAVYMVAIASH---RASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFN 379

  Fly   363 H-QGFRTDFMLDIVELTPAGI---------------RKIGTWNSTLPDGINFTRTFSQKQQEIEA 411
            . .|.|.||.|||:.|...|.               :|||.|||.  .|:|.|.....:...|..
Mouse   380 KTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSN--SGLNMTDGNRDRSNNITD 442

  Fly   412 NLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSL 476
            :|.|:||:|||||..||.|.::|..||.|||:||||.:||:.|:|..|||.|.::|||||.||:.
Mouse   443 SLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQ 507

  Fly   477 NKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFL 541
            |. .||||||::||::.|||||:|.||||:.||:.:||:.|||.||:|||||||....|.:||||
Mouse   508 ND-KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFL 571

  Fly   542 SPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQ 604
            :|||.|:|:|:..|.||||.:||::|:||||||  |...:...:.||:.|||||..||.:|:|||
Mouse   572 NPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQ 636

  Fly   605 QGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALK 669
            ||.:.:|||||||:|.|||||||||:|||||||||||||||||:|||:||:||||||:|:|||::
Mouse   637 QGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVR 701

  Fly   670 GGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN 734
            .|||..||:.||||||::||:||.|.:.|....::.||::||.  ...||.|||||||||||:||
Mouse   702 DGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVL--TTDYALLMESTSIEYVTQRN 764

  Fly   735 CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSK 799
            |.|||:||::|:|.||:.||..||||..|...||:||||||||::|.|||   ||.| |..|.||
Mouse   765 CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEEDSK 825

  Fly   800 SSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
            .:||   ||:.|:||:|:||..|:.::..:|:.||::||||
Mouse   826 EASA---LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRK 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	156/398 (39%)
		ANF_receptor	42..378	CDD:279440	143/353 (41%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	227/371 (61%)
		Lig_chan	547..823	CDD:278489	166/277 (60%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	157/401 (39%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	228/374 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1931
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	803	1.000	Inparanoid score	I497
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm42822
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.780