DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grid2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	928	Identity:	276/928 - (29%)
Similarity:	434/928 - (46%)	Gaps:	166/928 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLPLLLLQLILNCR--KAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQI 70
            |.||||.......|  ...:...||.||.:|..:....:..||.||..:|.:..||...|:...:
Mouse     3 VFPLLLFLSFCWSRTWDLATADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSV 67

  Fly    71 ERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------------- 120
            ..:...:.|.|.:..|.|:|.|:.|:.......:|..:||:.|.|.||||
Mouse    68 TFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCG 132

  Fly   121 ---ENR-WDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHG 181
               .|| .||.|       ::.| |..|::..:.:|..:.|:.|.|.|::...|..:||.|.
Mouse   133 LTRSNRNDDYTL-------SVRP-PVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD--- 186

  Fly   182 MTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHE-------------VLKQAQQIG 233
                     ::|..| ....|::::|:....|.....|.||.|             |:..|....
Mouse   187 ---------KVSQQG-MDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKS 241

  Fly   234 MMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLR-------- 290
            .:|:.....:.:.|.|.:.::|            .||:..|.::||: ||....::|
Mouse   242 FISEVVETNLVAFDCHWIIINE------------EINDVDVQELVRR-SIGRLTIIRQTFPVPQN 293

  Fly   291 ------------SANLTTVRSETA--------LMYDAVHLFAKALH-DLDTSQQIDIHPISC--D 332
                        |::|...:...|        .:||.|.|.|.|.| .|:..:...:..:||  .
Mouse   294 ISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRK 358

  Fly   333 GQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIV-----ELTPAGIRKIGTWNSTL 392
            ....||.|.|::..:|...:.|||..::|...|...:...:|:     |....|:||:|.||..
Mouse   359 NSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPV- 422

  Fly   393 PDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISK 457
             .|:|.:.|    .:::|.|::...|.|.|:|..|:.|..|:.  |....:::|:::|::..:|.
Mouse   423 -TGLNGSLT----DKKLENNMRGVVLRVVTVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALSN 480

  Fly   458 SLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLG 522
            .|||||:|.:.||..|||..: .|.|||::.||:.:|||:.|:.||||.:||..|||||.:|:..
Mouse   481 YLGFNYEIYVAPDHKYGSPQE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYS 544

  Fly   523 VSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTP--YEWPAYTDAHGEKV 585
            |.:|.|: .::..::|:.|:|..|.:|..:|...|.|.:|:::|....|  .:..:.|..
Mouse   545 VGVLLRR-AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTST----- 603

  Fly   586 ESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSP 650
                ||.|.|||..||.:|||.:.....|:|||:.|.||.|.||:|||||||||||||:.|::|.
Mouse   604 ----TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESS 664

  Fly   651 IESAEDLAKQTRIKYGA-----------LKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASN 704
            |:|.:||:|||.|.||.           :||  ...|.||   |.|.:||        .:...||
Mouse   665 IQSLQDLSKQTDIPYGTVLDSAVYQHVRMKG--LNPFERD---SMYSQMW--------RMINRSN 716

  Fly   705 GE---------GVERVAKGKGSYAFLMESTSIEYV--TERNCELTQVGGMLDTKSYGIATPPNSP 758
            |.         |:::|.  .|:|||:.::..:|||  .:.:|....||..:..:.||||....||
Mouse   717 GSENNVLESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSP 779

  Fly   759 YRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETS-KSSSAANELGLANVGGVFVVLMGG 822
            ||...:..||:||:.|.:.|||.|||.:   .|:|.:.:| .:......|.:.::.|||.:|..|
Mouse   780 YRDVFSQRILELQQSGDMDILKHKWWPK---NGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAG 841

  Fly   823 MGVACVIAVCEFVWKSRK 840
            :.::|:|||.|..|..||
Mouse   842 IVLSCLIAVLETWWSRRK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	99/433 (23%)
		ANF_receptor	42..378	CDD:279440	89/403 (22%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	147/393 (37%)
		Lig_chan	547..823	CDD:278489	105/300 (35%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		80/354 (23%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	100/436 (23%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	147/393 (37%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810