DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Gria4

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	860	Identity:	343/860 - (39%)
Similarity:	504/860 - (58%)	Gaps:	79/860 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAV--DRINADRSILPRSKLVAQIERISPFDSFHAGKRVCG 87
            :.|..::|||||....|.:..|||.|:  ...:.:.|..| ..||..::.|...:||......|.
Mouse    22 AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAP-FNLVPHVDNIETANSFAVTNAFCS 85

  Fly    88 LLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESCLVNLYPHPNTL 144
            ..:.||.||||.....:...:.|.|..:.|..:        |:::..:||            .:|
Mouse    86 QYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLR------------PSL 138

  Fly   145 SKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD--YRPLLKQIKN 207
            ..|.:.::.|:.|..|..:|:.:.|...||.:::..|...:.::...:.:..|  ||.||:::..
Mouse   139 RGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203

  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI-- 269
            ..|...|:||..||:..:|:|...:|. :..|| |::.:|....::|:.|.:||.|:|||:|:
Mouse   204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYH-YIIANLGFKDISLERFIHGGANVTGFQLVDF 267

  Fly   270 NEKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDG 333
            |..:|:.::.:| .:|::....|.  |..:..:||.||.|.:.|:....| ..|:|||......|
Mouse   268 NTPMVTKLMDRWKKLDQREYPGSE--TPPKYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAG 329

  Fly   334 Q------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN--- 389
            .      :.|..|..:...:|.|.::|||..::|||.|.|.::.:|:.||...|.||:|.||
Mouse   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMD 394

  Fly   390 -----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAV 449
                 ...|...|.|           |.::|:|:|||||:.:||.|.|::.....|||::|||.|
Mouse   395 KLVLIQDAPTLGNDT-----------AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCV 448

  Fly   450 DLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDF 514
            ||..||:|.:|..|||.:||||.||:.:..|..||||:.||:..:|::|||.||||..||:.:||
Mouse   449 DLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDF 513

  Fly   515 TTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTD 579
            :.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||
Mouse   514 SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW----- 573

  Fly   580 AHGEKVE-----------SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISS 633
             |.|:.|           ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||
Mouse   574 -HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISS 637

  Fly   634 YTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698
            ||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::||::|.||.||
Mouse   638 YTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPS 702

  Fly   699 VFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTA 762
            |||.:..|||.||.|.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..||.
Mouse   703 VFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTP 767

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            :|..:|||.|.|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.
Mouse   768 VNLAVLKLSEAGVLDKLKNKWWYDK---GECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAM 829

  Fly   828 VIAVCEFVWKSRKVA 842
            ::|:.||.:|||..|
Mouse   830 LVALIEFCYKSRAEA 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	107/395 (27%)
		ANF_receptor	42..378	CDD:279440	93/357 (26%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	207/381 (54%)
		Lig_chan	547..823	CDD:278489	153/287 (53%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	106/388 (27%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	210/389 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820