Protein Alignment KaiR1D and GRIN3B

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 190/840 - (22%)
• Similarity: 314/840 - (37%)
• Gaps: 184/840 - (21%)

  Fly    92 GVAAIFG-PQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYPHP-----------NTL 144
            ||||:.. |::......:..:....|.|.|.     .||||:......|:|           .||
Human    99 GVAALLAFPEARPELLQLHFLAAATETPVLS-----LLRREARAPLGAPNPFHLQLHWASPLETL 158

  Fly   145 SKAYVDIVRHWGWKTFTIIY---ENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD------YRP 200
            ....|.:::...|:...:..   ::..|:|.|  .....|..|..:......|:||      ..|
Human   159 LDVLVAVLQAHAWEDVGLALCRTQDPGGLVAL--WTSRAGRPPQLVLDLSRRDTGDAGLRARLAP 221

  Fly   201 LLKQIKNSA--EAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLD---LHTVNLDEFRYGG 260
            :...:...|  .|.::|.|...|...||:     .:....|..|.|.|.   |.|..|
Human   222 MAAPVGGEAPVPAAVLLGCDIARARRVLE-----AVPPGPHWLLGTPLPPKALPTAGL------- 274

  Fly   261 TNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQID 325
                                    ..|||....:.....|.|: :|.|.|.|:|   |.::.|:.
Human   275 ------------------------PPGLLALGEVARPPLEAAI-HDIVQLVARA---LGSAAQVQ 311

  Fly   326 IH------PISC-DGQSTWQH--GFSLINYMKIVEMKGLTNVI------------KFDHQGFRTD 369
            ..      |::| |.|.....  |..|..::.....:|.|..:            .|.....|.|
Human   312 PKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRD 376

  Fly   370 FMLDIVELTPAGI---RKIGTWNS---TLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPY 428
                     |.|.   ..:|:|..   .|..|....|....:..::...|:     |.|:|.:|:
Human   377 ---------PRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLR-----VVTLLEHPF 427

  Fly   429 -----------CMRKESAIPLSGNDQFE----------------------GYAVDLIHEISKSLG 460
                       |...:..:....||...                      ||.:||:..:::...
Human   428 VFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTP 492

  Fly   461 FNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSI 525
            |::::.||.||.||:|.  .|.|.|::.:||..||.:|:...:|...|.|.||||:||.:..:.|
Human   493 FDFELYLVGDGKYGALR--DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGI 555

  Fly   526 LYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKF-TPYEW--PAYTDAHGEKVES 587
            :.|......| :.:|:.||....|       |||...|.:.|.| |.|||  |......|....:
Human   556 MVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHLTALFLTVYEWRSPYGLTPRGRNRST 612

  Fly   588 QFTLLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPI 651
            .|:..:.:......|.::.... .||..:.|::..:|..|.|:::|||||||||.:..::....:
Human   613 VFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEEL 677

  Fly   652 ESAED--LAKQTR-IKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAK 713
            ....|  |....: .::|.:...|..|:.:.|    :..|.:.|.  |.|..|...|..:.....
Human   678 SGIHDPKLHHPAQGFRFGTVWESSAEAYIKKS----FPDMHAHMR--RHSAPTTPRGVAMLTSDP 736

  Fly   714 GKGSYAFLMESTSIEYVT--ERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776
            .|.: ||:|:.:.::|..  :.:|:|..||.....:.|||..|.|||..:.::..|.:.:..|.:
Human   737 PKLN-AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFI 800

  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANE---LGLANVGGVFVVLMGGMGVACVIAVCE 833
            .:|..||:|        .|...|...|..|   :.:.:..|:||:|..|:|.|.:.::.|
Human   801 DLLHDKWYK--------MVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGE 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	70/360 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	105/411 (26%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	29..401	CDD:380600	70/357 (20%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	105/414 (25%)
		Lig_chan	574..841	CDD:459656	72/288 (25%)