DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GRIN3A

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	884	Identity:	200/884 - (22%)
Similarity:	357/884 - (40%)	Gaps:	158/884 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AVDRINADRSILPRS---KLVAQIER------ISPF---------DSFHAGKRVCGLLNI-GVAA 95
            |||.:|....:||.:   ::|..||.      :.||         |.|...:.||..:.: ||:|
Human   131 AVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSA 195

  Fly    96 IFG-PQSSHTASHVQSICDNMEIPHLE-NRWDYRLRRESCLVNLYPHPNTLSK---AYVDIVRHW 155
            :.. |||......:..:...:.||.:. .|.::....::.|.......|:||.   ..|.|:...
Human   196 LLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMN 260

  Fly   156 GWKTFTII-----YENNDGIVRLQELLKAHGMTPFPITVRQLSDSGDYRPL----LKQIKNSAEA 211
            .|..|:::     :...|.::..|...|.|..:...||. .|..:.|....    |:.||||...
Human   261 NWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITA-NLPSTQDLLSFLQIQLESIKNSTPT 324

  Fly   212 HIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEKIVSD 276
            .::..|..|.|..:.:...|.|:|.....:::..    :.|::|.|..|..: |. :.:.|....
Human   325 VVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD----SQNVEELRTEGLPL-GL-IAHGKTTQS 383

  Fly   277 VVRQWSIDEKGLLRS--ANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQH 339
            |...:..|...|:..  |..|.::.|.||:...::.......:|.:.|.
Human   384 VFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQY---------------- 432

  Fly   340 GFSLINYMKIVEMKGLTNVIKFDHQ---GFRTDFMLDIVELTPAG---IRKIGTWNS---TLPDG 395
               |..::.....:||:..|:....   ....:|.:..::..|.|   ..::|:|..   .:..|
Human   433 ---LSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYG 494

  Fly   396 INFTRTFSQKQQEIEANLKNKT---LVVTTILSNPYCMRKE------------------------ 433
            |     :.::.|..:.:.::.:   |.|.|::.:|:...:|
Human   495 I-----WPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTL 554

  Fly   434 -----------SAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMI 487
                       ..:|:.......||.:||:.:|::.:.|::.:.:|.||.||:..  .|.|.|::
Human   555 DSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLV 617

  Fly   488 RELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYM 552
            .:||...|.:|:...:|...|.|.:|||:||.:..:.||.|......| :.:|:.||...:|
Human   618 GDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW--- 678

  Fly   553 ATAYLGVSVLLFILAKF-TPYEW--PAYTDAHG---EKVESQFTLLN-CMWFAIGSLMQQGCDFL 610
                ||:.|.|.|.|.| |.|||  |......|   .||.|..:.|| |.....|..:   ....
Human   679 ----LGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTV---AIKP 736

  Fly   611 PKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAED--LAKQTR-IKYGALKGGS 672
            ||..:.|.:..:|..|.:..:|:|||||||.:..|::...:....|  |...:: .::|.::..|
Human   737 PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESS 801

  Fly   673 TAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSY-AFLMESTSIEYVT--ERN 734
            ...:.|.|....::.|..:...|.|        :|||.:....... ||:|:...::|..  :.:
Human   802 AEDYVRQSFPEMHEYMRRYNVPATP--------DGVEYLKNDPEKLDAFIMDKALLDYEVSIDAD 858

  Fly   735 CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSK 799
            |:|..||.....:.|||..|||||....|:.:|.:.:..|.:.:|..||::.        |...|
Human   859 CKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRV--------VPCGK 915

  Fly   800 SSSAANE---LGLANVGGVFVVLMGGMGVACVIAVCEFV 835
            .|.|..|   :|:.:..|:||:|..|.|::.:..:.|.:
Human   916 RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	77/390 (20%)
		ANF_receptor	42..378	CDD:279440	72/365 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	108/420 (26%)
		Lig_chan	547..823	CDD:278489	79/291 (27%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	78/396 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	72/363 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	107/416 (26%)
		Lig_chan	676..942	CDD:278489	79/291 (27%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		1/4 (25%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810