Protein Alignment KaiR1D and Grik4

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 866
• Identity: 347/866 - (40%)
• Similarity: 521/866 - (60%)
• Gaps: 55/866 - (6%)

  Fly     3 SSGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQE------LAFRQAVDRINADRSIL 61
            |:.:::||..||.:..:       |..::|..:.   ||..|      |:...|.:|||.....|
Mouse     5 SAPLVLLPAWLLMVACS-------PHSLRIAAIL---DDPMECSRGERLSITLAKNRINRAPERL 59

  Fly    62 PRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASH-VQSICDNMEIPHL----E 121
            .::|:...|..:.....:...:.:|.:|..||.|:.||.||..:|. :.:||...|:||.    |
Mouse    60 GKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPE 124

  Fly   122 NRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFP 186
            ....::|:|.:.| ||:|....:|.|...|:..:...|..:|....:.::.|::||:...::...
Mouse   125 EFVRFQLQRFTTL-NLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDT 188

  Fly   187 ITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTV 251
            ::||.|.|:.|..||||:|::...|.|::..:....|.:|.:|.::||:|.|::|:.|:|:....
Mouse   189 LSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQ 253

  Fly   252 NLDEFRYGGTNITGFRLIN------EKIVSDVVRQW--SIDEKGLLRSANLTTVRSETALMYDAV 308
            .:|.......||.||.:.|      ::....:.:.|  :.|.      ...|.....:||::|||
Mouse   254 RMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDH------VPFTGPALSSALLFDAV 312

  Fly   309 HLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLD 373
            :....|:.:|:.||:|.:.|:||.....||||.||:||:::||::|||..|:|:.:|.|:::.|.
Mouse   313 YAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALK 377

  Fly   374 IVELTPAGIRKIGTWNSTLPDGINF-TRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIP 437
            |::.|..|.::||.|:  :.:|::. :|.::   ..|..:|.|.||||||||.|||.|.|.:...
Mouse   378 ILQFTRNGFQQIGQWH--VAEGLSMDSRLYA---SNISDSLFNTTLVVTTILENPYLMLKGNHQE 437

  Fly   438 LSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADL 502
            :.|||::||:.||::.|:::.|.|||||:||.||.|| :.:..|.|.||:.||:.::||||:|.|
Mouse   438 MEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVGELIARKADLAVAGL 501

  Fly   503 TITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILA 567
            |||.|||:.:||:.|||.||:|||||..:.:.|..||||.|.|..||::|..|||.||.:||::|
Mouse   502 TITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   568 KFTPYEW-PAYTDAHG--EKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLI 629
            :.||||| ..:..|.|  ..:.:|::|.|.:||.:|..||||....|:|||||.|:|:||.||||
Mouse   567 RLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLI 631

  Fly   630 MISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMES 694
            :||||||||||||||:||:.||||.:|||.||.|:||.:.|||:..||::|:..||||||::|.|
Mouse   632 IISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYS 696

  Fly   695 ARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPY 759
            .:||||..|..||:.||.  ..:||||:|||..||..:|||.|||:||:||||.|||..|..|.:
Mouse   697 KQPSVFVKSTEEGIARVL--NSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVF 759

  Fly   760 RTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMG 824
            |...:..||:|||..:|.|||.|||:    ||||..|   ....|..||:.|:||:||||:.|:.
Mouse   760 RDEFDLAILQLQENNRLEILKRKWWE----GGKCPKE---EDHRAKGLGMENIGGIFVVLICGLI 817

  Fly   825 VACVIAVCEFVWKSRKVAVEE 845
            ||..:|:.||:|..|.....|
Mouse   818 VAIFMAMLEFLWTLRHSEASE 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	111/388 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	202/372 (54%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	111/389 (29%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	202/372 (54%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956