DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and grik2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_017949808.1	Gene:	grik2 / 100495093	XenbaseID:	XB-GENE-5902331	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	406/853 - (47%)
Similarity:	585/853 - (68%)	Gaps:	41/853 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QSLPDIIKIGGLFHPADD----HQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKR 84
            |....:::.||:|...:.    .:|||||.||:.||.:|::||.:.|....:||:.:|||.|.::
Frog    35 QGTTHVLRFGGIFEYVESGPFGAEELAFRFAVNTINRNRTLLPNTTLTYDTQRINLYDSFEASRK 99

  Fly    85 VCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNTLSKA 147
            .|..|::||||||||..|.:|:.|||||:.:.:||::.||.:::  .::|..|:|||..::||:|
Frog   100 ACEQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRA 164

  Fly   148 YVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKNSAEA 211
            .:|:|:.:.|||.||.|:::.|::|||||:||.......:.:|||. |:.|.:||||::|...|.
Frog   165 ILDLVQFFKWKTVTIAYDDSTGLIRLQELIKAPSRYNLRLKIRQLPIDTKDAKPLLKEMKRGKEF 229

  Fly   212 HIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIV 274
            |::.|||.:....:||||..:|||::|:.|:.|:|||..::::.:||.|.|:||||::|  ...|
Frog   230 HVIFDCSHDMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNIENSQV 294

  Fly   275 SDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISC 331
            ..::.:||::        :.||| ...:||   :.||||||||:.:.|:...   .|:.:..:.|
Frog   295 LSIIEKWSMERLQAPPKPDSGLL-DGFMTT---DAALMYDAVHVVSVAVQQF---PQMTVSSLQC 352

  Fly   332 DGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGIRKIGTWNSTLPDG 395
            :....|:.|...|:.:|....:|||..|.|:. .|.||||.||::.|...|:.|||||:.|  .|
Frog   353 NRHKPWRFGARFISLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPT--SG 415

  Fly   396 INFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLG 460
            :|.|.....|...|..:|.|::|:|||||..||.|.|:|..||.|..:||||.:||:.::||.||
Frog   416 LNMTENQKGKPANITDSLSNRSLIVTTILEEPYVMFKKSDKPLYGKARFEGYCIDLLEKLSKILG 480

  Fly   461 FNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSI 525
            |.|:::||.||.||:.:..|.:||||:|||::.:||||:|.|.||:.|||.:|||.|||.||:||
Frog   481 FEYEVRLVEDGKYGAKDDTTQQWNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMTLGISI 545

  Fly   526 LYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW--PAYTDAHGEKVESQ 588
            |||||....|.:||||:|||.|:|:|:..||||||.:||::|:|:||||  |...:...:.||:.
Frog   546 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENN 610

  Fly   589 FTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIES 653
            |||||..||.:|:|||||.:.:|||||||:|.|||||||||:|||||||||||||||||:|||:|
Frog   611 FTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 675

  Fly   654 AEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSY 718
            |:||||||:|:|||::.|:|..||:.|:|.||::||:||.|...||...:|.||::||.  ...|
Frog   676 ADDLAKQTKIEYGAVQDGATMTFFKKSRIPTYEKMWAFMNSRSQSVLVKNNEEGIQRVL--TSDY 738

  Fly   719 AFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKW 783
            |||||||:||:||:|||.|||:||::|:|.||:.||..||||..|...||:|||||.||::|.||
Frog   739 AFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGVLHMMKEKW 803

  Fly   784 WKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVA-VEER- 846
            |   ||.| |..|.||.:||   ||:.|:||:|:||..|:.::..:||.||::||:|.| :|:|
Frog   804 W---RGNG-CPEEESKEASA---LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRS 861

  Fly   847 -LSAILNE 853
             .||::.|
Frog   862 FCSAMVEE 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	148/383 (39%)
		ANF_receptor	42..378	CDD:279440	136/349 (39%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	220/371 (59%)
		Lig_chan	547..823	CDD:278489	163/277 (59%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	149/385 (39%)
grik2	XP_017949808.1	Periplasmic_Binding_Protein_Type_2	435..805	CDD:419667	221/374 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1977
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40717
Inparanoid	1	1.050	790	1.000	Inparanoid score	I503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm47932
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060