DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and grik1

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	895	Identity:	424/895 - (47%)
Similarity:	594/895 - (66%)	Gaps:	68/895 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSSGVLVLPLLLLQLILNCRKA----QSLPDIIKIGGLFHPADDH----QELAFRQAVDRINAD 57
            |.|:..|:||.|       |..|    |:...:::|||:|...::.    :||||:.||..||.:
Frog    19 MESAARLLLPFL-------CALAAITPQASQQVLRIGGIFETVENEPINVEELAFKFAVTNINRN 76

  Fly    58 RSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLEN 122
            |:::|.:.|...|:||:.||||.|.:|.|..|.:||||:|||..|.:.|.|||||:.:|:||::.
Frog    77 RTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 141

  Fly   123 RWDYRL--RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPF 185
            ||.:..  .::|..:||:|....:|:|.:::|.|:.|||.|::||::.|::|||||:||......
Frog   142 RWKHPSVDNKDSFFINLHPDYAAISRAVLELVLHYSWKTVTVVYEDSTGLIRLQELIKAPSRYNI 206

  Fly   186 PITVRQL-SDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLH 249
            .|.:||| |.:.|.|.|||::|.|.|.:::.|||.|...|:|||...:|||::|:.|..|::||.
Frog   207 KIKIRQLPSGNKDARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMDLF 271

  Fly   250 TVNLDEFRYGGTNITGFRLIN--EKIVSDVVRQWSID--------EKGLLRSANLTTVRSETALM 304
            .::|:.:||.|.|:|||||:|  ...||.||.:||::        |.||| ...:||   :.|||
Frog   272 ALDLEPYRYSGVNMTGFRLLNIDNPQVSSVVEKWSMERLQAPPKPETGLL-DGMMTT---DAALM 332

  Fly   305 YDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRT 368
            ||||::.|.|   ...:.|:.:..:.|.....|:.|...::.:|.....|||..|.|:. .|.|.
Frog   333 YDAVYMVAVA---TQRATQMTVSSLQCHRHKPWRFGPRFMSLIKEARWDGLTGRITFNRTDGLRR 394

  Fly   369 DFMLDIVELTPAGI---------------RKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTL 418
            ||.:||:.|...|:               :|:|.|||.  .|:|.|.....|...|..:|.|:||
Frog   395 DFDMDIISLKEDGMEKAAGETVNHLNKVWKKVGVWNSN--TGLNMTDNLKDKSTNITDSLANRTL 457

  Fly   419 VVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEW 483
            :|||||.:||.|.::|..||.|||:||||.:||:.|:|..|||.|:::||.||.||:.|. .|||
Frog   458 IVTTILEDPYVMFRKSDKPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYGAQND-KGEW 521

  Fly   484 NGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDV 548
            |||:|||::.:||||:|.||||:.||:.:||:.|||.||:|||||||....|.:||||:|||.|:
Frog   522 NGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDI 586

  Fly   549 WIYMATAYLGVSVLLFILAKFTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLP 611
            |:|:..|.||||.:||::|:||||||  |...:...:.||:.|||||..||.:|:|||||.:.:|
Frog   587 WMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMP 651

  Fly   612 KALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAF 676
            ||||||:|.|||||||||:|||||||||||||||||:|||:||:||||||:|:|||::.|||..|
Frog   652 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTF 716

  Fly   677 FRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVG 741
            |:.||||||::||:||.|.:.:....:|.||::||.  ...||.|||||||||||:|||.|||:|
Frog   717 FKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQRVL--TTDYALLMESTSIEYVTQRNCNLTQIG 779

  Fly   742 GMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANE 806
            |::|:|.||:.||..||||..|...||:||||||||::|.|||   ||.| |..|.||.:||
Frog   780 GLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEEDSKEASA--- 837

  Fly   807 LGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVA-VEERLS--AILNE 853
            ||:.|:||:|:||..|:.::..:|:.||::||||.: :|:.||  ||:.|
Frog   838 LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIEQCLSFNAIMEE 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	152/398 (38%)
		ANF_receptor	42..378	CDD:279440	140/353 (40%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	226/371 (61%)
		Lig_chan	547..823	CDD:278489	166/277 (60%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	153/403 (38%)
		ANF_receptor	61..404	CDD:279440	140/349 (40%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	227/374 (61%)
		Lig_chan	585..854	CDD:278489	166/277 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1977
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	790	1.000	Inparanoid score	I503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm47932
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060