Protein Alignment KaiR1D and grin2b

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 961
• Identity: 217/961 - (22%)
• Similarity: 379/961 - (39%)
• Gaps: 215/961 - (22%)

  Fly    12 LLLQLILNCRKAQSLPD----IIKIGGL-------FHPADDHQELAFRQAVDRINADRSILPRSK 65
            |::...:.| .||..|:    :|.:|..       .|..||...|             .:.||..
 Frog    14 LIILFYMGC-YAQKHPNMDIAVILVGTTDEVAIKDVHEKDDFHHL-------------PVTPRVA 64

  Fly    66 LVAQIERISPFDSFHAGKRVCGLLN----IGVAAIFGPQSSHTASHVQSICDNMEI----PHLEN 122
            ||...|.    |......|:|.|::    .||  :||..:...|  :..|.|.:.:    |.|..
 Frog    65 LVTMNES----DPKSIITRICDLMSDKKVQGV--VFGDDTDQEA--IAQILDFISVQTLTPILGI 121

  Fly   123 RWDYRL-----RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTII------YENNDGIVR---- 172
            .....:     ...|......|.....:...::|:..:.|..|:|:      |::.:..||
 Frog   122 HGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIE 186

  Fly   173 -------LQELLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQ 230
                   |:|:          |.:....|..|.: :..|:|......|:|.|:.|....:.:.|.
 Frog   187 NSFVGWELEEV----------IHLDMSLDDNDSK-IQNQLKKLQSPVILLYCTKEEATYIFEVAH 240

  Fly   231 QIGMMSDYHSYLVTSL---DLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRS- 291
            .:|:....::::|.||   |..||.. ||..|             ::|....:|..|....:|.
 Frog   241 SVGLTGYGYTWIVPSLVAGDTDTVPA-EFPTG-------------LISVSYDEWDYDLPARVRDG 291

  Fly   292 -ANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGL 355
             |.:||..|.....::::.....:.:::..|:..:.|              .|..|:..|..:|.
 Frog   292 IAIITTAASTMLSEHNSIPQSKSSCYNIQESRVYEAH--------------MLKRYLINVTFEGR 342

  Fly   356 TNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQ-----EIEANL-- 413
            .  :.|...|::....|.|:.|...  ||   |...   |....|:...|..     |:..|.
 Frog   343 N--LSFSEDGYQMHPKLVIILLNQQ--RK---WERV---GKYKDRSLKMKYYVWPVFELYPNSEE 397

  Fly   414 -KNKTLVVTTILSNPYCMRKESAIPLSGNDQ--------------------------FEGYAVDL 451
             |::.|.:.|:...|:.: .|...||||...                          .:|:.:|:
 Frog   398 HKDEHLSIVTLEEAPFVI-VEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGFCIDI 461

  Fly   452 IHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTT 516
            :.:|:|::.|.|.:.||.:|.:|  .|:.|.|||||.|::.:||.:|:..|||..||.:.|||:.
 Frog   462 LKKIAKTVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSV 524

  Fly   517 PFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVS-VLLFILAKFTPYEWPAYTD 579
            ||:..|:|::. |......|:  :||.|.|.|||:.|....|.|| |.:|:...|:|..:.....
 Frog   525 PFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLA 587

  Fly   580 AHGEKVESQFTLLNCMWFAIGSLMQQGCDFL-PKALSTRMVAGIWWFFTLIMISSYTANLAAFLT 643
            ...|.....||:...:|...|.:........ ||..:::::..:|.||.:|.::|||||||||:.
 Frog   588 DGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMI 652

  Fly   644 VERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSF-MESARPSVFT 701
            .|.....:....|...|      ...::|.:..|||....|::.:..:..|..| ..|.:.::.:
 Frog   653 QEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLS 717

  Fly   702 ASNGEGVERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPNSPYRTA 762
            ...|:          ..||:.::..:.|:..|:  |:|..:|.  :..|..||||...:|.::..
 Frog   718 LKTGK----------LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQ 772

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            ::..||:|..:|::..|:..|..     |.|..|  |:...:::|.:.|:.|||.:|...|.::.
 Frog   773 VDLAILQLFGDGEMEELEALWLT-----GICHNE--KNEVMSSQLDIDNMAGVFYMLAAAMALSL 830

  Fly   828 VIAVCE--FVWKSRK--------------------------VAVEERLSAI 850
            :..:.|  |.|:.|.                          |.:|:|.||:
 Frog   831 ITFIMEHLFFWQLRHCFMGVCSGKPGVVFSISRGIYSCIHGVPIEDRQSAM 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	77/410 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	109/409 (27%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	80/424 (19%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	111/419 (26%)
		NMDAR2_C	837..1449	CDD:463148	8/45 (18%)