Protein Alignment KaiR1D and grin2a

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 893
• Identity: 205/893 - (22%)
• Similarity: 353/893 - (39%)
• Gaps: 224/893 - (25%)

  Fly    31 KIGGLFHPADDHQELAFRQAVDRINADRSILP-------RSKLVAQIERISPFDSFHAG--KRVC 86
            ||.|:....|..|| |..|.:|.::: ::.:|       .|.::|..:.:|.|..|.|.  ::..
 Frog    86 KIHGVVFGDDTDQE-AIAQILDFVSS-QTFIPILGIHGGSSMIMADKDEMSTFFQFGASIKQQAI 148

  Fly    87 GLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYPH--------PNT 143
            .:|||                       ||        :|.....|.:.:.:|.        ..|
 Frog   149 VMLNI-----------------------ME--------EYDWHVFSIITSTFPGYRDFISFIKTT 182

  Fly   144 LSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNS 208
            :..::|      ||:...:|                           .|..|......|.|:|..
 Frog   183 VDNSFV------GWEVQNVI---------------------------TLDTSYTDARTLTQLKKI 214

  Fly   209 AEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLD----EFRYGGTNITGFRLI 269
            ..:.|:|.||.:..:.:..:|:.:|:|.....::|.|  |.|.|.|    ||..|
 Frog   215 HSSVILLYCSKDEANYIFVEARSLGLMGYGFVWIVPS--LVTGNTDIIPYEFPSG---------- 267

  Fly   270 NEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPI----- 329
               :||.....|..:.:..:|               |.:.:...|     .|..::.|.:
 Frog   268 ---LVSVSYDDWDYNIEARVR---------------DGLGIITTA-----ASAMLEKHSVIPEAK 309

  Fly   330 -SCDGQSTWQHG--FSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELT-PAGIRKIGTW-- 388
             ||..|:.....  .:|..:|..|...|  ..:.|...|::.:..|.::.|. .....|:|.|
 Frog   310 TSCYAQNERNEPPLHTLHKFMINVTWDG--KDLSFTEDGYQANPKLVVLLLNMDREWEKVGKWEN 372

  Fly   389 ---NSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPY------------CMRKESAIPL 438
               |...|.....|.:       ::::..:..|.:.|:...|:            |:|  :.:|.
 Frog   373 KSLNMKYPVWPRITAS-------LDSDPDDNHLSIVTLEEAPFVIVENVDYLTGTCVR--NTVPC 428

  Fly   439 S-----GNDQFE---------GYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRE 489
            .     .|...|         |:.:|::.::||::.|.|.:.||.:|.:|  .|:...|||||.|
 Frog   429 RKYFRLNNSTTEGTSVKKCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHG--KKIKNVWNGMIGE 491

  Fly   490 LLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMA 553
            ::.:||.:|:..|||..||.:||||:.||:..|:|::. |......|:  :||.|.|..||:.|.
 Frog   492 VVYKRAVMAVGSLTINEERSEAVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMF 554

  Fly   554 TAYLGVS-VLLFILAKFTPYEWPA-YTDA---HGEKVESQFTLLNCMWFAIGSLMQQGCDFL-PK 612
            ...|.|| |.:|:...|:|..:.. ..|.   ||    ..||:...:|...|.:........ ||
 Frog   555 VMLLLVSAVAVFVFEYFSPVGYNRNLADGKAPHG----PSFTIGKAVWLLWGLVFNNSVPVQNPK 615

  Fly   613 ALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQ------TRIKYGALKGG 671
            ..:::::..||.||.:|.::|||||||||:..|.....:....|...|      ...::|.:..|
 Frog   616 GTTSKIIVSIWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNG 680

  Fly   672 STAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVE----RVAKGKGSYAFLMESTSIEYVTE 732
            ||....|::....:|.|..|.:            :||:    .:..||.. ||:.::..:.|:..
 Frog   681 STERNIRNNYPDMHQYMVKFHQ------------KGVQDALVSLKTGKLD-AFIYDAAVLNYMAG 732

  Fly   733 RN--CELTQVGG--MLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKC 793
            |:  |:|..:|.  :..|..||||....|.::..|:..:|:...:|::..|:..|..     |.|
 Frog   733 RDEGCKLVTIGSGYIFATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWLT-----GIC 792

  Fly   794 RVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCE--FVWKSR 839
              .|.|:...:::|.:.|:.|||.:|...|.::.:..|.|  |.||.|
 Frog   793 --HTEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFVWEHLFYWKLR 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	74/403 (18%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	113/416 (27%)
grin2a	XP_031749422.1	PBP1_iGluR_NMDA_NR2	26..379	CDD:380601	73/395 (18%)
		PBP2_iGluR_NMDA_Nr2	395..793	CDD:270436	115/427 (27%)
		NMDAR2_C	831..1450	CDD:463148	4/8 (50%)