DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and grid2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_031759030.1	Gene:	grid2 / 100487676	XenbaseID:	XB-GENE-955038	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	899	Identity:	269/899 - (29%)
Similarity:	431/899 - (47%)	Gaps:	152/899 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGV 93
            ||.||.:|..:....:..||.||..:|.:..||...|:...:..:...:.|.|.:..|.|::.|:
Frog    26 IIHIGAIFDESAKKDDEVFRMAVADLNLNEDILQTEKITFSVTFVDGNNPFQAVQEACDLMSQGI 90

  Fly    94 AAIFGPQSSHTASHVQSICDNMEIPHL-ENRWDYRLRRESC-----------LVNLYPHPNTLSK 146
            .|:.......:|..:||:.|.|.|||| ..|...|..|..|           .:::.| |..|:.
Frog    91 LALVSSIGCASAGSLQSLADAMHIPHLFIQRSTARTPRSGCGLQRSSGIDDYTLSVRP-PVYLND 154

  Fly   147 AYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEA 211
            ..:.:|..:.|:.|.:.|:||..|..:||.|.            ::|..| ....|::::|:...
Frog   155 VILRVVTEYAWQKFIVFYDNNYDIRGIQEFLD------------RVSQQG-MDVALQKVENNINR 206

  Fly   212 HIVLDCSTERIHEV------LKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFR--- 267
            .|....:|.||.|:      |::|..:...:...:::...::             ||:..|.
Frog   207 MITGLFATMRIEELNRYRDTLRRAILVMSPTTAKAFITEVVE-------------TNLVAFDCHW 258

  Fly   268 -LINEKI----VSDVVRQWSIDEKGLLRSA-----NLT------TVRSETAL------------- 303
             :|||:|    |.::||: ||....::|..     |.:      ..|..|:|
Frog   259 IIINEEINDLDVQELVRR-SIGRLTIIRQTFPVPHNSSQRCFRGNHRISTSLCDPKDPFSQNMEI 322

  Fly   304 ----MYDAVHLFAKALH-DLDTSQQIDIHPISC--DGQSTWQHGFSLINYMKIVEMKGLTNVIKF 361
                :||.|.|.|.|.| .|:..:...:..::|  .....||.|.|::..:|...:.|||..:.|
Frog   323 TNMYIYDTVLLLANAFHKKLEDRKWHSMASLTCIRKNSKPWQGGRSMLETVKKGGVSGLTGALDF 387

  Fly   362 DHQGFRTDFMLDIV-----ELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVT 421
            ...|...:...:|:     |....||||:|.||..  .|:|.:.|    .:::|.|::...|.|.
Frog   388 SEDGGNPNIYFEILGTNYGEELGRGIRKLGFWNPV--TGLNGSLT----DRKLENNMRGVVLRVA 446

  Fly   422 TILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGM 486
            |:|..|:.|..|:.  |....:::|:::|::..:|..|||.|:|.:..|..||| .:..|.|||:
Frog   447 TVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALSSYLGFKYEIYVASDHKYGS-PQADGSWNGL 508

  Fly   487 IRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIY 551
            |.|||.:|||:.|:.||||.:||..|||||.:|:..|.:|.|| .::..::|:.|:|..|.:|..
Frog   509 IGELLLKRADMGISALTITPDRENVVDFTTRYMDYSVGVLLRK-AEKTVDMFACLAPFDLSLWAC 572

  Fly   552 MATAYLGVSVLLFILAKFTP--YEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKAL 614
            :|...|.|.:|:::|....|  .:..:.|..         ||.|.|||..||.:|||.:.....|
Frog   573 IAGTVLLVGLLVYLLNWLNPPRLQMGSMTST---------TLYNSMWFVYGSFVQQGGEVPYTTL 628

  Fly   615 STRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGA-----------L 668
            :|||:.|.||.|.||:|||||||||||||:.|::|.|:|.:||::||.|.||.           :
Frog   629 ATRMMMGAWWLFALIVISSYTANLAAFLTISRIESSIQSLQDLSRQTDIPYGTVFDSAVYEHVRV 693

  Fly   669 KGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNG---------EGVERVAKGKGSYAFLMES 724
            ||.:  .|.||   |.|.:||        .:...|||         ||:::|.  .|:|||:.::
Frog   694 KGMN--PFERD---SMYSQMW--------RMINRSNGSENNVQESLEGIQKVK--HGNYAFVWDA 743

  Fly   725 TSIEY--VTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEK 787
            ..:||  :.:::|....||..:..:.||||....||||...:..||:||:.|.:.|||.|||..
Frog   744 AVLEYIAINDQDCSFYTVGNTIADRGYGIALQHGSPYRDIFSQRILELQQNGDMDILKHKWWPR- 807

  Fly   788 RGGGKCRVETS-KSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
              .|:|.:.:| .:....:.|.:.:..|||.:|..|:.::|.||:.|..|..:|
Frog   808 --NGQCELHSSMDTKQKGSSLDIKSFSGVFCILAAGIVLSCFIAMVETWWNKKK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	100/427 (23%)
		ANF_receptor	42..378	CDD:279440	89/397 (22%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	147/393 (37%)
		Lig_chan	547..823	CDD:278489	104/300 (35%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:415822	101/430 (23%)
grid2	XP_031759030.1	PBP2_iGluR_delta_2	440..806	CDD:270449	147/393 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910