DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and grin2cb

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	929	Identity:	218/929 - (23%)
Similarity:	387/929 - (41%)	Gaps:	172/929 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLQLILNCRKAQSL-PDIIKIGGLFHPADDHQELAFRQAVD-------RINADRSIL----PRS 64
            |||.::..||..... |..:.:..:|..:..|.|:..|.:.:       .:|....::    ||:
Zfish    20 LLLNVVPRCRGRPFFGPPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPITVLVNDTNPRA 84

  Fly    65 KLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDN--MEIPHLENRWDYR 127
             |:.::.:....:|.|.......:.:..||.|....||.|:..:..|...  :.|||..:
Zfish    85 -LLTRLCQTMAAESLHGVVFEDDVDSEAVAQILDFVSSQTSIPIVGISGGSAVVIPHKAD----- 143

  Fly   128 LRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTII------YENNDGIVR-----------LQE 175
               .|..:.:....:....|...::..:.|..|.:|      ||.....:|           ||:
Zfish   144 ---GSTFLQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTDTSYFLWELQD 205

  Fly   176 LLKAHGMTPFPITVRQLSDSGDYRP--LLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDY 238
            :|.      |.::|    .:.|.|.  ||:|:  .::.::|. ||.|....:.:.|..:|::...
Zfish   206 VLS------FEMSV----GANDIRTRRLLQQV--DSQVYLVY-CSHEEAQYLFRMASDVGLLGPG 257

  Fly   239 HSYLVTSLDLHTVNLDE------FRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTV 297
            :.::|.||   .|...|      |..|             ::|.:..:|        |......|
Zfish   258 YIWIVPSL---AVGNPEAAPPASFPVG-------------VISIITDRW--------RKTLRQRV 298

  Fly   298 RSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIV--EMKGLTNVIK 360
            |...|::...||.|.|....:.........|:.....:      ||..:|..|  |.|.|:
Zfish   299 REGVAIIVKGVHSFHKHRGFIPEGHSDCSSPVKSYANN------SLFRHMLNVSWEHKDLS---- 353

  Fly   361 FDHQGFRTDFMLDIVELTPAG-IRKIGTWNSTL--------PDGINFTRTFSQKQQEIEANLKNK 416
            |:..|:.|:..:.|:.|.... ..|:|::...:        |...:|....|..:....|.|:.:
Zfish   354 FNSDGYLTNPSMVIIALDRENHWDKVGSYEGGILQMRYPVWPRYGSFLEPVSDNRHLTVATLEER 418

  Fly   417 TLVV---------TTILSNPYCMRK----ESAIPLSGNDQ------FEGYAVDLIHEISKSLGFN 462
            ..|:         |.:.:...|.|:    ||.|   |:.:      .:|:.:|::.::|:::.|:
Zfish   419 PFVIVESVDPATGTCVRNTVPCRRQSNRTESII---GHTEPYTKLCCKGFCIDILKKLSRTIKFS 480

  Fly   463 YKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILY 527
            |.:.||.:|.:|.:  :.|.|||||.|:..:|||:||..|||..||.:.|||:.||:..|:|::.
Zfish   481 YDLYLVTNGKHGKM--VRGVWNGMIGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMV 543

  Fly   528 -RKPIKQPPNLFSFLSPLSLDVWIYMATAYLG-VSVLLFILAKFTPYEWPAYTDAHGEKVESQFT 590
             |......|:  :||.|.|..||:.|....|. |:|.:|:...|:|..:.....:........||
Zfish   544 ARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPGGPTFT 606

  Fly   591 LLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESA 654
            :...:|...|.:....... .||..:::::..:|.||.:|.::|||||||||:..|:....:...
Zfish   607 IGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGL 671

  Fly   655 EDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVER--- 710
            .|...|      ...::|.:..|||....|    |.|..|.:.|        ...|.:|||.
Zfish   672 SDKKFQKPQEHYPPFRFGTVPNGSTERNIR----SNYPDMHTHM--------IKYNQKGVEEALN 724

  Fly   711 -VAKGKGSYAFLMESTSIEYVT--ERNCELTQVGG--MLDTKSYGIATPPNSPYRTAINSVILKL 770
             :..||.. ||:.::..:.|:.  :..|:|..:|.  :..|..||||...:|.::..|:..:|:.
Zfish   725 SLKTGKLD-AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQF 788

  Fly   771 QEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFV 835
            ..:|....|:|.|.     .|.|:.|  |:...:::|.:.|:.|||.:|:..||::.::...|.:
Zfish   789 LGDGDTQRLETVWL-----SGICQNE--KNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 846

  Fly   836 --WKSR-KVAVEERLSAIL 851
              ||.| .|...:||..:|
Zfish   847 LYWKLRHSVHKSDRLDFLL 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	77/414 (19%)
		ANF_receptor	42..378	CDD:279440	72/375 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	111/405 (27%)
		Lig_chan	547..823	CDD:278489	74/291 (25%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	76/414 (18%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	115/425 (27%)
		NMDAR2_C	845..>932	CDD:313729	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810