DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and LOC100331381

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_017207884.1	Gene:	LOC100331381 / 100331381	-ID:	-	Length:	1063	Species:	Danio rerio

Alignment Length:	878	Identity:	366/878 - (41%)
Similarity:	528/878 - (60%)	Gaps:	80/878 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLPLLLLQLILNCRKAQS----LPDI--IKIGGLFHPADDH------QELAFRQAVDRINADRS 59
            |:|.:.||.|:|....|.|    :|.:  :::..:.   ||.      :.||...|.:.||:...
Zfish     7 LLLSIHLLFLVLLLTMAPSSHSQVPALSAVRMAAIL---DDQSACGRGERLALALARENINSLME 68

  Fly    60 ILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSS-HTASHVQSICDNMEIPHLE-- 121
            ...|:::...|..:.....:.....:|.:|..||.::.||.|| .:.|.|..||...||||::
Zfish    69 GPARARVEVDIFELQRDSQYETTDTMCQILPKGVVSVIGPASSPASGSTVSHICGEKEIPHIKIG 133

  Fly   122 ----NRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGM 182
                .|..| ||..|  |.|||....||.|...|:|.:|:.|.::|....:.::||:||::...:
Zfish   134 PEETPRLPY-LRFAS--VTLYPSNEDLSLAIGAILRSFGYPTASLICAKAECLLRLEELVRHFLI 195

  Fly   183 TPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLD 247
            :...::||.|.::.|..||||:|::...|.|::|.:......:||:|.::||.|.::.|::|::|
Zfish   196 SRETLSVRMLDENLDPTPLLKEIRDDKVATIIIDANASVSILILKKASELGMTSAFYKYILTTMD 260

  Fly   248 LHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRS-----------ET 301
            ...:.||:.....:||.||.::|..      ..:.::   .:||.||:....           .:
Zfish   261 FPLLRLDDVVNDQSNIVGFSMLNNS------HPFYLE---FIRSLNLSWREGCDLSPYPGPALSS 316

  Fly   302 ALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGF 366
            |||:||||:...|:.:|:.||:|.:.|:||.....||||.||:||:::||..|||..::|:.:|.
Zfish   317 ALMFDAVHVVVGAVRELNRSQEIGVKPLSCTSSLIWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQ 381

  Fly   367 RTDFMLDIVELTPAGIRKIGTW--------NSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTI 423
            ||::.|.|:|....|.::||.|        |||..| ||.:.|           |.||||.||||
Zfish   382 RTNYTLRILEKFKGGHKEIGVWYSNNTLAMNSTSLD-INTSET-----------LANKTLTVTTI 434

  Fly   424 LSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIR 488
            |.|||.||||:.....|:||:||:.||::.|::..|.|:::|:||.||.||: .:..|.|.||:.
Zfish   435 LENPYVMRKENYQDFQGSDQYEGFCVDMLRELADILKFSFRIKLVDDGLYGA-PEPNGSWTGMVG 498

  Fly   489 ELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMA 553
            ||:.::||||:|..|||.|||:.:||:.||||||:|||||..|.:.|..||||.|.|..||::|.
Zfish   499 ELINRKADLAVAGFTITSEREKVIDFSKPFMNLGISILYRVHIGRKPGYFSFLDPFSPAVWLFML 563

  Fly   554 TAYLGVSVLLFILAKFTPYEW----PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKAL 614
            .|||.||.:||:.|:.:||||    |.:.:.. :.:|:|:||.|.:||.||..||||.:.:|:||
Zfish   564 LAYLAVSCVLFLAARLSPYEWYNPFPCWRERR-DLLENQYTLGNSLWFPIGGFMQQGSEIMPRAL 627

  Fly   615 STRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRD 679
            |||.|:|:||.||||:||||||||||||||:||:.|||||||||.||.|:||.::||||..||.:
Zfish   628 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESAEDLADQTNIQYGTIQGGSTMTFFMN 692

  Fly   680 SKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGML 744
            |:..||||||::|.|.:||||..|..||:.||...|  ||||:|||..||....||.|||:||:|
Zfish   693 SRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSK--YAFLLESTMNEYHRRLNCNLTQIGGLL 755

  Fly   745 DTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGL 809
            |||.|||..|..||:|..|...||:|||..:|.|||.:||:    ||||..|   ....|..||:
Zfish   756 DTKGYGIGMPLGSPFRDEITLGILQLQENNRLEILKRRWWE----GGKCLKE---EDHRAKGLGM 813

  Fly   810 ANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVA 842
            .|:||:||||:.|:.:|..:|:.||||.:|:.|
Zfish   814 DNIGGIFVVLICGLIIAVFVAIMEFVWSTRRSA 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	121/397 (30%)
		ANF_receptor	42..378	CDD:279440	111/359 (31%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	207/373 (55%)
		Lig_chan	547..823	CDD:278489	152/279 (54%)
LOC100331381	XP_017207884.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950