DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and si:dkey-183j2.10

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_001923977.1	Gene:	si:dkey-183j2.10 / 100151589	ZFINID:	ZDB-GENE-130530-729	Length:	465	Species:	Danio rerio

Alignment Length:	432	Identity:	167/432 - (38%)
Similarity:	252/432 - (58%)	Gaps:	28/432 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   418 LVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGE 482
            |:||||..:||.|.|.|        |.|||.:||:.|::|.|||.||:.||.|||||..:: .|.
Zfish    31 LIVTTIKQDPYTMSKGS--------QLEGYCMDLLTELAKKLGFKYKVHLVKDGSYGRQDE-NGN 86

  Fly   483 WNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPI-KQPPNLFSFLSPLSL 546
            |||||.|::...||||:|.||:|..||:||..|.|:|..|:|||.||.| .:....|.||||.|.
Zfish    87 WNGMIGEVVRGEADLAVAPLTLTAAREKAVGMTKPYMQTGISILLRKDIVSEEAGFFDFLSPFSG 151

  Fly   547 DVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLP 611
            :.|..:..||...:|.:.|:.:.:|.||     :..|...:.||||:.:|:..|:|..||....|
Zfish   152 ETWFGILIAYFVTAVCICIVGRLSPCEW-----SQPETEPNHFTLLHSLWYTAGALSLQGAGPHP 211

  Fly   612 KALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAF 676
            ||:|.|:::..||.|.:::::.|.::|::....:.....|:..||||.|..|:||.|.|.||.||
Zfish   212 KAVSGRVISCTWWLFAVVLLACYFSSLSSTQGSDSAPLMIKGFEDLANQDVIEYGTLAGSSTLAF 276

  Fly   677 FRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVG 741
            |::|...:|:|::..||  |...|.:|..|||:: || :|:|||:.||.|::....|:|||.:..
Zfish   277 FKNSNNPSYRRIYEHME--RRKSFVSSMDEGVQK-AK-EGNYAFIGESVSLDLAVARHCELVRAH 337

  Fly   742 GMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANE 806
            .::..:.|.|.||..|.....::..||:|.|.|:|..|:||||     ...|..:.:|:||
Zfish   338 EVIGMRGYSIVTPLGSAMLKNLSVAILQLSEAGELAYLRTKWW-----ASSCLPDNAKASS---- 393

  Fly   807 LGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLS 848
            |...::.|:|:||..|:|:..::::.|...|||..|.|::.|
Zfish   394 LRAHSMKGIFLVLAIGLGIGVLLSLFELTTKSRSAAGEQKKS 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377
		ANF_receptor	42..378	CDD:279440
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	148/367 (40%)
		Lig_chan	547..823	CDD:278489	93/275 (34%)
si:dkey-183j2.10	XP_001923977.1	PBP2_iGluR_non_NMDA_like	28..381	CDD:270403	149/372 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.770