DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and LOC100149482

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	881	Identity:	199/881 - (22%)
Similarity:	350/881 - (39%)	Gaps:	198/881 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PRSKLVAQIER--------ISPFDSFHAGKRVCGLLNIGVAAIFG--PQ---------SSHTASH 107
            |...||.:.||        ::|...|.:.:....::.:|..|..|  ||         ||.||..
Zfish   118 PLQGLVYEDERPLPLATGPLAPMLEFVSAQTGLPIVAVGGGAALGRVPQESGSIFLQFSSSTALQ 182

  Fly   108 VQSICDNMEIPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIV---------RHWGWKTFTII 163
            ::.|.:.:|    |..|           ..:...:|....|.|.:         ...||:..:|:
Zfish   183 LEVIFEVLE----EYDW-----------TAFSVVSTRHHGYQDFLSVVEGLTDGSFIGWEKKSIV 232

  Fly   164 YEN---NDGIVRLQELLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEV 225
            ..|   :.|.||.|.|||                           :|.|:..: |.||.|...:|
Zfish   233 MLNLTDDPGGVRTQRLLK---------------------------ENEAQVRL-LYCSQEEAEQV 269

  Fly   226 LKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDE--KGL 288
            ...|...|.....|.:......|..:.|          ||   :.:::.:...:.|. ||  :.:
Zfish   270 FLAAWAAGQAGASHIWFAVGPALSELGL----------TG---LPKRLFAVRPQGWR-DEPRRRI 320

  Fly   289 LRSANLTTVRSETALMYD-----AVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMK 348
            .|..::.| ....||..|     ..|.......|.:.:|:|.                ..:.|..
Zfish   321 ARGVSILT-HGAVALRKDYGATGGPHFVTNCQTDGNRTQRIR----------------GRMRYFS 368

  Fly   349 IVEMKGLTNVIKFDHQGFRTDFMLDIVELTP-AGIRKIGTW-NSTL----------------PDG 395
            .:.:.|  ....|.::|:..:..||::..|| :|...:|.| |..|                ||.
Zfish   369 NITLGG--RDYSFSNEGYLANPFLDVISYTPGSGWEDVGWWENGVLRLRYPAWSRYGPFLQPPDD 431

  Fly   396 INFTRTFSQKQQEIEANLKNKTLVV---------TTILSNPYCMR-------KESAIPLSGNDQF 444
            ....|.         ..|:.:..|:         |.|..:..|.|       :|...|:  ....
Zfish   432 AQHLRV---------VTLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQEGVAPV--KQCC 485

  Fly   445 EGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFERE 509
            :|:.:|::..:::.:||.|.:.||.:|.:|  .|:.|.||||:.|::.:|||:||..|||..||.
Zfish   486 KGFCIDILKRLARIVGFTYDLYLVTNGKHG--KKIDGVWNGMVGEVVYKRADMAIGSLTINEERS 548

  Fly   510 QAVDFTTPFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLG-VSVLLFILAKFTPY 572
            :.|||:.||:..|:|::. |......|:  :||.|.|..||:.|....|. |:|.:||...|:|.
Zfish   549 EVVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPV 611

  Fly   573 EWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTA 636
            .:.....:..:...|:||:...:|.....:....... .||..:::::..:|.||.:|.::||||
Zfish   612 GYNRSLQSGKKAGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTA 676

  Fly   637 NLAAFLTVERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESA 695
            |||||:..|.....:....|...|      ..:|:|.:..|||....|.:....:|.|..:.:.
Zfish   677 NLAAFMIQEEYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRSNYPDMHQYMVKYNQK- 740

  Fly   696 RPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPN 756
                   |..:.:..:..||.. ||:.::..:.|:..::  |::..:|.  :..|..||||...|
Zfish   741 -------SVEDAISHLKTGKLD-AFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKN 797

  Fly   757 SPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMG 821
            |.::..::..:|:|..:.::.:|:..|.     .|.|  ...|....:::|.:.|:.|||.:|:.
Zfish   798 SRWKRPLDLALLQLVGDDEIEMLERLWL-----SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLV 855

  Fly   822 GMGVACVIAVCEFV--WKSR----KVAVEERLSAIL 851
            .||::.::...|.:  |:.|    |:....:|..:|
Zfish   856 AMGLSLLVFAWEHLVYWRLRHCMSKMGQSGKLDFLL 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	75/390 (19%)
		ANF_receptor	42..378	CDD:279440	66/353 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	105/398 (26%)
		Lig_chan	547..823	CDD:278489	68/287 (24%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	73/378 (19%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	109/428 (25%)
		HisJ	<487..>570	CDD:223904	34/84 (40%)
		Lig_chan	585..857	CDD:278489	68/287 (24%)
		NMDAR2_C	868..>900	CDD:287527	5/24 (21%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810