DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and gria3

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	887	Identity:	342/887 - (38%)
Similarity:	519/887 - (58%)	Gaps:	67/887 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSSGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRS- 64
            |..:.|..:.||||.|:  .......|:.|.|||||......:..||..||...|.:::...|.
Frog     1 MGQNEVQTVFLLLLSLV--GESCGGFPNTINIGGLFMRNTIQEHSAFLFAVQLHNTNQNNTERPF 63

  Fly    65 KLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNME----IPHLENRWD 125
            :|...::.:...:||......|...:.||.||||.....:.:.:.|.|..:.    .|......|
Frog    64 QLFHHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFITPSFPTDAD 128

  Fly   126 YRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVR 190
            .:.     ::.:.|   .|..|.:.::..:.|:.|..:|:...|...||.:::|.....:.:|.|
Frog   129 VQF-----VIQMRP---PLKGAILTLLNEYDWQKFVYLYDTERGFSILQAIMEAAVQNNWQVTAR 185

  Fly   191 ---QLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVN 252
               .:.|..:::.:::::....|...|:||..|||:.:|:|...:|..:..:.|::.:|......
Frog   186 SVGNIKDVQEFKRIIEEMDRRQEKRFVIDCEVERINTILEQVVILGKHTRGYHYMLANLGFTGFT 250

  Fly   253 LDEFRYGGTNITGFRLINEK--IVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKA 314
            |:...:||.|:|||:::|.:  ||...:::| .:||:....:.| |.::..:||.:|||.:.|:|
Frog   251 LERVMHGGANVTGFQIVNNENPIVQQFLQRWVRLDEREFPEARN-TPLKYTSALTHDAVLVIAEA 314

  Fly   315 LHDLDTSQQIDIHPISCDGQS------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLD 373
            ...| ..|::|:......|..      .|..|..:...:|:|:::|:|..|:||..|.||::.:|
Frog   315 FRYL-RRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTID 378

  Fly   374 IVELTPAGIRKIGTWNS-----TLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKE 433
            :.|:|....||:|.||.     ..||         |:.....::::|||::|||||.|||.|:|:
Frog   379 VYEMTATKPRKVGHWNEYERFVPAPD---------QQPTNESSSVENKTIIVTTILENPYVMKKK 434

  Fly   434 SAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLA 498
            :...|.|||::|||.|||..||:|.:|..||:.:|.||.||:.:..|..||||:.||:..|||:|
Frog   435 NHELLDGNDKYEGYCVDLASEIAKHVGIKYKLSIVEDGKYGARDPETKIWNGMVGELVYGRADIA 499

  Fly   499 IADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLL 563
            :|.||||..||:.:||:.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:|
Frog   500 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 564

  Fly   564 FILAKFTPYEWPAYTDAHGEKVE------------SQFTLLNCMWFAIGSLMQQGCDFLPKALST 616
            |::::|:||||      |.|..:            ::|.:.|.:||::|:.||||||..|::||.
Frog   565 FLVSRFSPYEW------HLEDTDEARDPQNPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSG 623

  Fly   617 RMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSK 681
            |:|.|:|||||||:|||||||||||||||||.|||||||||||||.|.||.|..|||..|||.||
Frog   624 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSK 688

  Fly   682 ISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLD 745
            |:.|::|||:|:||.|||||.:..:||.||.|.||.:|||:|||..||:.:|. |:..:|||.||
Frog   689 IAVYEKMWSYMKSAEPSVFTKTTDDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLD 753

  Fly   746 TKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLA 810
            :|.||:|||..|...|.:|..:|||.|:|.|..||.|||.:|   |:|..:.|.|....:.|.|:
Frog   754 SKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDK---GECGAKDSGSKDKTSALSLS 815

  Fly   811 NVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLSAILN 852
            ||.|||.:|:||:|:|.::|:.||.:|||  |..:|:....|
Frog   816 NVAGVFYILVGGLGLAMMVALIEFCYKSR--AESKRMKLTKN 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	98/387 (25%)
		ANF_receptor	42..378	CDD:279440	85/352 (24%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	207/382 (54%)
		Lig_chan	547..823	CDD:278489	151/288 (52%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	96/380 (25%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	210/390 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.130