DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and grin2ca

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001352716.1	Gene:	grin2ca / 100003342	ZFINID:	ZDB-GENE-070822-3	Length:	1400	Species:	Danio rerio

Alignment Length:	947	Identity:	230/947 - (24%)
Similarity:	393/947 - (41%)	Gaps:	187/947 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGVLVLPLLLLQLILN-----CRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDR-INADRSILP 62
            |..|.||:|||..:.:     ||....:...:.:..:|..:....|:..|.:.:. ::....:.|
Zfish     9 SDTLWLPVLLLLSVCSVPCCQCRPFGMVEPTVNVAVVFSGSAYQTEIKGRLSRENFLDLPLEVNP 73

  Fly    63 RSKLV------AQIERISPFDSFHAGKRVCGLL---NIG---VAAIFGPQSSHTASHVQSICDN- 114
            .:.||      ..:.||.  |:. |..||.|::   |||   ||.|....|:.||..:..|...
Zfish    74 ITVLVNNTNPRTLLTRIC--DTL-AANRVHGVVFEDNIGSEAVAQILDFISTQTAVPIVGISGGS 135

  Fly   115 -MEIPHL-------------------------ENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVR 153
             :.:||.                         |..||..:    .:.:|||..:|    |||.:|
Zfish   136 AVVLPHKGDGSTFLQLGSSIEQQINGMFKVMEEYNWDSFV----VVTSLYPGYDT----YVDYIR 192

  Fly   154 HWGWKTFTIIYENNDGIVRLQELL----KAHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIV 214
            .: ..|...::|       ||:.|    .|.||.....           |.||:||    :|.::
Zfish   193 SF-IDTSYFLWE-------LQDTLTFDMSADGMNDLRA-----------RRLLQQI----DAQVL 234

  Fly   215 L-DCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNL---DEFRYGGTNITGFRLINEKIVS 275
            | .||.:....:...|:::|::...:.:.:.||.:...|:   |.|..|             ::|
Zfish   235 LVYCSHDEAQYLFSMAREVGLVGPGYIWFIPSLAVGNPNIAPPDSFPVG-------------LIS 286

  Fly   276 DVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHG 340
            .:..:|.:.    ||:    .||...|::...|..|.|....:.......:.||......|.
Zfish   287 IITDRWKMS----LRN----RVRDGVAIVVKGVESFRKQRGFIPDGHMDCLSPIRPASNGTL--- 340

  Fly   341 FSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIR--KIGTWNSTL--------PDG 395
                 |..::.:........|:..|:..:..:.|:.| ..|.:  |:|.:.|.:        |..
Zfish   341 -----YRHMLNVSWENTDFSFNSDGYLVNPSMIIITL-DRGRQWDKVGNYESGILQMRYPVWPRY 399

  Fly   396 INFTRTFSQKQQEIEANLKNKTLVVT--------TILSNPYCMRKES--AIPLSGNDQ------F 444
            ..|....|..:....|.|:.:..|:.        |.|||....|::|  ...:.|:.:      .
Zfish   400 GTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYTKLCC 464

  Fly   445 EGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFERE 509
            :|:.:|::.::|:::.|:|.:.||.:|.:|.|  :.|.|||||.|:..:|||:||..|||..||.
Zfish   465 KGFCIDILKKLSRNIKFSYDLYLVTNGKHGKL--VRGIWNGMIGEVFYKRADMAIGSLTINEERS 527

  Fly   510 QAVDFTTPFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLG-VSVLLFILAKFTPY 572
            :.:||:.||:..|:|::. |......|:  :||.|.|..||:.|....|. |:|.:|:....:|.
Zfish   528 EIIDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYCSPV 590

  Fly   573 EWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTA 636
            .:.....:..:.....||:...:|...|.:....... .||..:::::..:|.||.:|.::||||
Zfish   591 GYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTA 655

  Fly   637 NLAAFLTVERMDSPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESA 695
            |||||:..|:....:....|...|      ...::|.:..|||....|    |.|..|.|.|
Zfish   656 NLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIR----SNYPEMHSHM--- 713

  Fly   696 RPSVFTASNGEGVE----RVAKGKGSYAFLMESTSIEYVT--ERNCELTQVGG--MLDTKSYGIA 752
                 ...|.:|||    .:..||.. ||:.::..:.|:.  :..|:|..:|.  :..|..||||
Zfish   714 -----VKYNQKGVEDALNSLKTGKLD-AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIA 772

  Fly   753 TPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFV 817
            ....|.::..|:..:|:...:|....|:|.|..     |.||.|  |....:::|.:.|:.|||.
Zfish   773 LQKESRWKRPIDLALLQFLADGDTQKLQTVWLT-----GICRNE--KKEVMSSKLDIDNMAGVFY 830

  Fly   818 VLMGGMGVACVIAVCEFV--WKSR-KVAVEERLSAIL 851
            :|:..||::.::...|.:  ||.| .|...|||..:|
Zfish   831 MLLVAMGLSLLVFAWEHLLYWKLRHSVRKSERLDFLL 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	84/423 (20%)
		ANF_receptor	42..378	CDD:279440	77/383 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	111/402 (28%)
		Lig_chan	547..823	CDD:278489	75/291 (26%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	83/423 (20%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	115/422 (27%)
		NMDAR2_C	847..>938	CDD:313729	8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810