DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GLR1.3

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	834	Identity:	158/834 - (18%)
Similarity:	280/834 - (33%)	Gaps:	254/834 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 INVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILLIAITDSDCPRLPLNRALMVPIV 142
            |||  |.||:|.|         |.:..:.|      :|:..||:.....:..|:   ::.:...|
plant   168 INV--FDWNSVAL---------VYEDHDDW------RESMQLLVEHFHENGVRV---QSKVGFTV 212

  Fly   143 ENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVKSIVH--ESITNHITPISLILYEIN 205
            .:.::|    :..::||:.:..|.|.                :||  |.|..|:.|.:
plant   213 SSSEDF----VMGRLQQLKDLGTTVF----------------VVHLSEVIATHLFPCA------- 250

  Fly   206 DSLRGQQKRVALRQALSQFAPKKHEEMRQQFL------VISAFHEDIIEIAETLNMFHVGNQWMI 264
                   :|:.|              |...|:      .:::|||:|.:..:......||.:..|
plant   251 -------RRLGL--------------MGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGFKSYI 294

  Fly   265 --------FVL----DMVARDFDAGTVTINLDEGANIAFALNETD-----PNCQDSLNCTISEIS 312
                    |.|    .:...:.:...::|:.....:|||||....     ||...:|   :.||:
plant   295 PMSIELQNFTLRWRKSLPVEEAELTRLSISGIWAHDIAFALARAAEVIRMPNVTSTL---LEEIT 356

  Fly   313 LALVNAISKITVEEESIYG--EISDEEWEAIRFTKQEKQAEIL------EYMKEFLKTNAKCS-- 367
            ....|.:|          |  :::|::..:.:|       ||:      |....||.:|...|
plant   357 KTRFNGLS----------GDFQLNDKKLLSNKF-------EIINMIGSSERRVGFLNSNGSFSNR 404

  Fly   368 ---SCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQELAFPHIEHH 429
               |....::||.|..|.|.::.|..|....|.|....             .|.....||.
plant   405 RHLSSTHNKLETIIWPGGSAQSPKGTSLIDSDRKKLRV-------------LVTSSNRFPR---- 452

  Fly   430 FRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAW---KEEDS 491
                   ::.|...|      .:|.:|||  |..:|:.:......|:..   |...|   ...|:
plant   453 -------LMKVETDP------VTNELIVE--GFCIEVFRASISPFNYEV---EYIPWLNGSNYDN 499

  Fly   492 LSTSAGGNES--DELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYS 554
            |:.:....:.  |..||.:|                 |.:..:|..|       :|.|.:.....
plant   500 LAYALHSQKDKYDAAVGDIT-----------------ITSNRSTYVD-------FTLPFTEMGLG 540

  Fly   555 FITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEMRIVGLSTVKSCFWYI 619
            .:..|.   ..:::|..|.|.:.|.......:||...::.|.| |..||.:......:....|:.
plant   541 IVAVKE---RSMWVFFQPLTPDLWITSAFFFVLTGVIVWLIER-AENKEFQGSWPQQIGVVLWFG 601

  Fly   620 FGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFP--KFQPGVDYLNQLEDHK 682
            |..|:......| ..:..|.||..|...|::|..:|...|.:.:|..  :|....||:..|....
plant   602 FSTLVYAHREKL-KHNLSRFVVTVWVFAVLILTASYTATLTSMMTVQQIRFNSNEDYVGHLSGSL 665

  Fly   683 DIVQYGLRNGTFFERYVQS---TTREDFKHYLERAKIYGSAQEEDIEAVKRGERINIDWRINLQ- 743
             |....|.:.:.  |.::|   .:..|:...|....:.....|.....|..||.....:.:..|
plant   666 -IANVALTSSSL--RAMRSLGLNSAADYAQALLNKTVSFVVDELPYLKVVLGENPTHFFMVKTQS 727

  Fly   744 ------LIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHI---KSMFRMGFIE- 798
                  .:.|:.||                     :||.       |:|.|   ::..::..:|
plant   728 TTNGFGFMFQKGFE---------------------LVPN-------VSREISKLRTSEKLNEMEK 764

  Fly   799 RWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLA---LLIVC 849
            ||....||..         ...|::.:.:...:|.|:::.:.|..|   |:|:|
plant   765 RWFDNQLPYT---------TDDTSNPITLYRFRGLFIIIGVSFAFALAVLVILC 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	53/274 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	52/275 (19%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	62/324 (19%)
		ANF_receptor	57..385	CDD:279440	57/304 (19%)
		GluR_Plant	438..767	CDD:270404	76/423 (18%)
		Lig_chan	559..798	CDD:278489	52/280 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100