DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GLR2.6

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001330285.1	Gene:	GLR2.6 / 830988	AraportID:	AT5G11180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	928	Identity:	172/928 - (18%)
Similarity:	300/928 - (32%)	Gaps:	305/928 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LILDAKVQQILNWKTAVVFVDQTILEENALL-------VKSIVHESITNHITPISLILYEINDSL 208
            ::|....|::|..:..:|      |:.||.|       :...:.|....|....:.|:..|.||
plant    24 VLLGKSQQEVLQVQVGIV------LDTNATLAALSLRAINMSLSEFYNTHNGFKTRIVLNIRDS- 81

  Fly   209 RGQQKRVALRQALSQ-FAPKKHE---------EMRQQFLV------------------------- 238
                ||..:..|.|. :..||.|         .|:..||:
plant    82 ----KRTVVGAAASALYLIKKREVVAIIGPGNSMQAPFLINLGNQSQVPIISFSASSPVLDSLRS 142

  Fly   239 ---ISAFHED---IIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGANI-------- 289
               |.|.|:|   :..|:..:..|    :|...|......:|..|.:...:|....|
plant   143 PYFIRATHDDSSQVHAISAIIESF----RWREVVPIYADNEFGEGILPYLVDAFQEINVRIRYRS 203

  Fly   290 AFALNETD-----------------------PNCQDSLNCTISEISLALVNAISKIT---VEEES 328
            |.:::.||                       |:....|.....||.:.....:..:|   .::.|
plant   204 AISVHSTDDLVKKELYKLMTMPTRVFIVHMLPDLGSRLFSIAKEIGMMTKGYVWIVTNGIADQMS 268

  Fly   329 IYGEISDEEWEAI----RFTKQEKQAEILE--YMKEF---LKTNAKCSSCARWRVETAITWGKSQ 384
            :.||.|.|....:    .:..:.|:...||  :.|.|   ...|.:|     |..:||.....|.
plant   269 VMGESSLENMHGVLGVKTYFSRSKELMYLETRWRKRFGGEELNNFEC-----WGYDTATALAMSI 328

  Fly   385 E------NRKF----RSTPQRDA----------------------------------KN-----R 400
            |      |..|    |:|.:.|.                                  ||     .
plant   329 EEISSNVNMSFSQTKRNTSRDDTGTDLDDLSFALSGPKLLQALATVSFKGVAGRFQLKNGKLEAT 393

  Fly   401 NFEFINI--------GYWTPVLGFVCQ------ELAFPHIEHHFRNITMDILTVHNPP-WQI--- 447
            .|:.:||        |:|...:|.|..      .:...|..|..|.|.....|:..|. |:.
plant   394 TFKIVNIEESGERTVGFWKSKVGLVKSLRVNQTGIKISHSSHRLRPIIWPGDTIFVPKGWEFPTN 458

  Fly   448 -------------------LTKNSNGVIVEHKGIVMEI----VKELSRALNFSYYLHEASAWKEE 489
                               :||::|.......|..:::    ::::..|:.:.|...|....|..
plant   459 AKKLRIAVPKKDGFNNFVEVTKDANTNAPTITGFCIDVFDTAMRQMPYAVPYEYIPFETPDGKPR 523

  Fly   490 ---DSLSTSAGGNESDELVGSMT----------FRIPYRVVEMVQGNQFFIAAVAATVEDPDQKP 541
               |.:.......|.|..||..|          |.:||....:|         |...|:|..:|
plant   524 GSYDEMVYHVFLGEFDGAVGDTTILANRSTYVDFALPYSETGIV---------VVVPVKDEREK- 578

  Fly   542 FNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEMRI 606
                                   ..::|..|.|.|.||       |||.:...|..:..:.|.:.
plant   579 -----------------------GKWVFLKPLTRELWF-------LTAASFLYIGIMVWIFEYQA 613

  Fly   607 VG-------LSTVKSCFWYIFGALLQQGGMYLPTADS--GRLVVGFWWIVVIVLVTTYCGNLVAF 662
            .|       ::.:.:.|::.|..|.   ..::..::|  .|::|..|..|:::|..:|...|.:.
plant   614 SGDFRKQSIINKISNVFYFSFSTLF---FAHMRPSESIFTRVLVVVWCFVLLILTQSYTATLTSM 675

  Fly   663 LTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTF-FERYVQSTTREDFKHYLERAKIYGSAQEEDIE 726
            ||..:.:|.|.:::.|.:..  |..|.:.|:| |||..|...:|      .|.|.|.:.||....
plant   676 LTVQELRPTVRHMDDLRNSG--VNIGYQTGSFTFERLKQMGYKE------SRLKTYDTPQEMHEL 732

  Fly   727 AVKRGERINIDWRIN----LQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRH 787
            .:|:.....||...:    ::|.:.::..:     :.:...:|..:......|..|..:..::|.
plant   733 FLKKSSNGGIDAAFDEVAYVKLFMAKYCSK-----YTIIEPTFKADGFGFAFPLGSPLVPDLSRQ 792

  Fly   788 IKSMFR---MGFIE-RWHQMNLPSAGKCNGKSAQRQVTNHKVNMD--DMQGCFLVLLLGFTLALL 846
            |.::..   |..|| :|    |.....|    .....::..:.:|  ..:..|.::.:...|.||
plant   793 ILNITEGETMKAIENKW----LLGEKHC----LDSTTSDSPIRLDHHSFEALFTIVFVVSMLLLL 849

  Fly   847 --IVCGEFWYRRFRASRK 862
              :||     ||:|...|
plant   850 AMLVC-----RRYRQESK 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	60/317 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	56/279 (20%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	72/402 (18%)
		GluR_Plant	460..810	CDD:270404	77/409 (19%)
		Lig_chan	590..842	CDD:365843	56/282 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010