DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GLR1.4

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	985	Identity:	183/985 - (18%)
Similarity:	322/985 - (32%)	Gaps:	320/985 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLLLLAGLQLSILVPTEANDFSSFLSANASLAVVVDHEYMTVHGENILAHFEKILSDVIRENLRN 75
            |::...|..|:|           |..|..|.||       |..|.|...:.:::  .|:.|::|.
plant     4 CMIRNTGYFLTI-----------FFLAFISFAV-------TCSGTNQKDNVDRL--PVVYEDVRI 48

  Fly    76 GGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFY--KNTQETSILLIAITDSDCPRLPLNRAL- 137
             |:.|...|.....:......|::        :||  .|...|.:.:::......|...|..|:
plant    49 -GLVVDMGSMEGKLVTTSISMALS--------DFYHVNNGYRTRVSVLSRDSHGDPLQALAAAMD 104

  Fly   138 -----MVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVK-----SIVHES--- 189
                 .|..:..|    |.:|:||....|..||.|..:....:..:..|.|     ...|::
plant   105 LLQTEQVEALVGG----QSLLEAKNLAELGEKTKVPVISSFQVPSSLSLAKYNYFIQATHDTSSE 165

  Fly   190 -------ITNHITPISLILYEINDSLRG---------QQKRVALRQALSQFAPKKHEE--MRQ-- 234
                   .:|.....::::||.:|..|.         ||..:.: :..::|:...:||  |:|
plant   166 AKGIAALFSNFDWRTAVLIYEDDDDWRESIQPLVGHFQQNAIHI-EYKAEFSVSSNEECIMKQLR 229

  Fly   235 QF------LVISAFHEDI----IEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGANI 289
            :|      :.::...|.|    ...|..|.|...|..|:     :.||..:
plant   230 KFKASGIRIFVAHISERIANRLFPCARRLGMMEEGYAWI-----LTARSMN-------------- 275

  Fly   290 AFALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGEISDEEW-----EAIRFTKQEKQ 349
                     |.||:             |.::|     |.:.|.|..:.:     |...||.:.|:
plant   276 ---------NFQDT-------------NYLAK-----EEMEGVIGFKSYIPLTEELHNFTLRWKR 313

  Fly   350 AEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRK---------FRSTPQRDAKNR----- 400
            :..||      :...:.|.|:.|..:.|.:..::.|..|         ..:.|: .||::
plant   314 SLRLE------EVVTRMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPE-SAKHKGLSGD 371

  Fly   401 -----------NFEFIN--------IGYW---------------TPVLGFVC---QELAFPHI-- 426
                       .||.:|        :|.|               |..|..:.   .....|.|
plant   372 IKFIDKKFISDKFEIVNMIGRGERSVGLWNSGSFISNRRRRLSSTKALETIIWPGGSTRIPKIRS 436

  Fly   427 ---EHHFR-----------NITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIVKELSRALNFS 477
               :.|.:           |||..||       ::.|....||... .|..:::.:  :..|.|:
plant   437 LKEKRHGKKKKLRVLVPAGNITPQIL-------EVKTDFKTGVTAA-TGYCIDVFE--TSILPFN 491

  Fly   478 YYLHEASAWKEEDSLSTSAGGNESDELVGSMTFR----IPYRVVEMVQGNQFFIAAVAATVEDPD 538
            |.: |...|.                  |::.::    :.|.:..  |.:::..|....|:.|..
plant   492 YEV-EYIPWP------------------GAINYKNYNDLVYTLYS--QKDKYDAAVGDITITDNR 535

  Fly   539 QKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKE 603
            ....::|.|.:....:.:|.|.   ..:::...|.|:..|..:....:||...::.|.|..
plant   536 SLYVDFTLPFTDMGLAVVTAKD---KSMWIIFKPLTLSLWLTIASFFILTGAIVWLIERHD---- 593

  Fly   604 MRIVGLSTVKSCFWYIFGALLQQGGMYLPTA-------DSGRLVVGFWWIVVIVLVTTYCGNLVA 661
                ......|||..| |.||..|...|..|       :..|.||..|...|::|.:.|...|.:
plant   594 ----NADFQGSCFQQI-GTLLCFGFSTLVFAHRERLQHNMSRFVVIVWIFAVLILTSNYTATLTS 653

  Fly   662 FLTFPKFQPGVDYLNQLEDHKDIVQYGLR--------NGTF-FERYVQSTTREDFKHYLERAKIY 717
            .:|       |..:..|:.:::|..:...        |.|| ..||....|.:||.:.|....|
plant   654 VMT-------VQQIRGLKSNENIGFFSASIAANVVNDNPTFQGPRYKGLKTADDFTNALRNGTI- 710

  Fly   718 GSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLH 782
             |...:::..||              |.|.:|     ...|.:.....|...........|..:.
plant   711 -SFIVDEVPYVK--------------LFVAKH-----PSEFVIVETESVTNGFGFAFQKGSPLVQ 755

  Fly   783 LVNRHIKSMFR---MGFIERWHQMNLPSAGKCNGKSAQRQVTN-------HKVNMDDMQGCFLVL 837
            .|:|.|:.:.|   :..||.|.              .|||.|:       |.:.:...:|.|::.
plant   756 KVSREIEKLRRTEKLKAIENWW--------------FQRQTTSATSEDTFHPLTVYTFRGLFMIT 806

  Fly   838 LLGFTLALLI 847
            .:.|..||::
plant   807 GVSFAFALIV 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	57/298 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	60/285 (21%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	75/429 (17%)
		ANF_receptor	64..390	CDD:279440	69/391 (18%)
		GluR_Plant	448..778	CDD:270404	79/414 (19%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	42/222 (19%)
		Lig_chan	570..810	CDD:278489	60/290 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100